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1.	Thery, C, et al. (author) Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines 2018 In: Journal of extracellular vesicles. - : Wiley. - 2001-3078. ; 7:1, s. 1535750- Journal article (peer-reviewed)
2.	Bevers, S, et al. (author) mRNA-LNP vaccines tuned for systemic immunization induce strong antitumor immunity by engaging splenic immune cells 2022 In: Molecular therapy : the journal of the American Society of Gene Therapy. - : Elsevier BV. - 1525-0024. ; 30:9, s. 3078-3094 Journal article (peer-reviewed)
3.	de Jong, OG, et al. (author) A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA 2020 In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1, s. 1113- Journal article (peer-reviewed)abstract Extracellular vesicles (EVs) form an endogenous transport system for intercellular transfer of biological cargo, including RNA, that plays a pivotal role in physiological and pathological processes. Unfortunately, whereas biological effects of EV-mediated RNA transfer are abundantly studied, regulatory pathways and mechanisms remain poorly defined due to a lack of suitable readout systems. Here, we describe a highly-sensitive CRISPR-Cas9-based reporter system that allows direct functional study of EV-mediated transfer of small non-coding RNA molecules at single-cell resolution. Using this CRISPR operated stoplight system for functional intercellular RNA exchange (CROSS-FIRE) we uncover various genes involved in EV subtype biogenesis that play a regulatory role in RNA transfer. Moreover we identify multiple genes involved in endocytosis and intracellular membrane trafficking that strongly regulate EV-mediated functional RNA delivery. Altogether, this approach allows the elucidation of regulatory mechanisms in EV-mediated RNA transfer at the level of EV biogenesis, endocytosis, intracellular trafficking, and RNA delivery.
4.	de Jong, OG, et al. (author) Publisher Correction: A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA 2020 In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1, s. 1701- Journal article (other academic/artistic)abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.
5.	Elsharkasy, OM, et al. (author) Extracellular vesicles as drug delivery systems: Why and how? 2020 In: Advanced drug delivery reviews. - : Elsevier BV. - 1872-8294 .- 0169-409X. ; 159, s. 332-343 Journal article (peer-reviewed)
6.	O'Loughlin, AJ, et al. (author) Functional Delivery of Lipid-Conjugated siRNA by Extracellular Vesicles 2017 In: Molecular therapy : the journal of the American Society of Gene Therapy. - : Elsevier BV. - 1525-0024. ; 25:7, s. 1580-1587 Journal article (peer-reviewed)

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Result 1-6 of 6

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Type of publication: journal article (6)

Type of content: peer-reviewed (5); other academic/artistic (1)

Author/Editor: EL-Andaloussi, S (5); Vader, P (5); Mager, I (3); Wood, MJA (3); Gupta, D. (2); Chen, S. (1); show more...; Jenster, G (1); Antoniou, A (1); Park, J (1); Sharma, S. (1); Yin, H. (1); Das, S. (1); Rak, J. (1); Schneider, R. (1); Krause, M. (1); Moller, A (1); Ortiz, A (1); Weiss, DJ (1); Leszczynska, A. (1); Ostrowski, M. (1); Xu, J (1); Sahoo, S. (1); Buch, S (1); Nejsum, P (1); Gabrielsson, S (1); Lötvall, Jan, 1956 (1); Cheng, L (1); Shiba, K (1); Wheelock, AM (1); Zheng, L (1); Kaur, S (1); Scott, A (1); Nawaz, Muhammad (1); Witwer, KW (1); Hunt, S (1); Chen, CC (1); Gardiner, C (1); Lim, R (1); Mullier, F (1); Baharvand, H (1); Huber, V. (1); Lehto, T (1); Zhao, ZZ (1); Anderson, JD (1); Ivanova, A (1); Gustafson, D (1); Nordin, JZ (1); Pulliam, L. (1); Tahara, H (1); Varela, MA (1); show less...

University: Karolinska Institutet (6); University of Gothenburg (1); Lund University (1)

Language: English (6)

Research subject (UKÄ/SCB): Medical and Health Sciences (3); Natural sciences (1)

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