SwePub
Sök i LIBRIS databas

  Utökad sökning

(id:"swepub:oai:DiVA.org:umu-184461")
 

Sökning: (id:"swepub:oai:DiVA.org:umu-184461") > Nicotinamide provid...

Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction

Tribble, James R. (författare)
Karolinska Institutet
Otmani, Amin (författare)
Karolinska Institutet
Sun, Shanshan (författare)
School of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom
visa fler...
Ellis, Sevannah A. (författare)
University of Melbourne, The Florey Institute of Neuroscience and Mental Health, Melbourne, Australia
Cimaglia, Gloria (författare)
Department of Clinical Neuroscience, Division of Eye and Vision, St. Erik Eye Hospital, Karolinska Institutet, Stockholm, Sweden; School of Optometry and Vision Sciences, Cardiff University, Cardiff, UK
Vohra, Rupali (författare)
Department of Veterinary and Animal Sciences, Pathobiological Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; Department of Drug Design and Pharmacology, Eye Translational Research Unit, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
Jöe, Melissa (författare)
Karolinska Institutet
Lardner, Emma (författare)
Department of Clinical Neuroscience, Division of Eye and Vision, St. Erik Eye Hospital, Karolinska Institutet, Stockholm, Sweden
Venkataraman, Abinaya P. (författare)
Karolinska Institutet
Domínguez-Vicent, Alberto (författare)
Karolinska Institutet
Kokkali, Eirini (författare)
School of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom
Rho, Seungsoo (författare)
School of Optometry and Vision Sciences, Cardiff University, Cardiff, UK; Department of Ophthalmology, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea
Jóhannesson, Gauti, 1979- (författare)
Umeå universitet,Oftalmiatrik,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)
Burgess, Robert W. (författare)
Jackson Laboratory, ME, United States
Fuerst, Peter G. (författare)
WWAMI Medical Education Program, University of Idaho, ID, Moscow, United States
Brautaset, Rune (författare)
Karolinska Institutet
Kolko, Miriam (författare)
Department of Drug Design and Pharmacology, Eye Translational Research Unit, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; Department of Ophthalmology, Copenhagen University Hospital, Rigshospitalet-Glostrup, Glostrup, Denmark
Morgan, James E. (författare)
School of Optometry and Vision Sciences, Cardiff University, Cardiff, UK; Cardiff Eye Unit, University Hospital Wales, Cardiff, UK; School of Medicine, Cardiff University, Cardiff, UK
Crowston, Jonathan G. (författare)
Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Australia; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore; Centre for Vision Research, Neuroscience and Behavioural Disorders, Duke-NUS, Singapore, Singapore
Votruba, Marcela (författare)
School of Optometry and Vision Sciences, Cardiff University, Cardiff, UK; Cardiff Eye Unit, University Hospital Wales, Cardiff, UK
Williams, Pete A. (författare)
Karolinska Institutet
visa färre...
 (creator_code:org_t)
Elsevier, 2021
2021
Engelska.
Ingår i: Redox Biology. - : Elsevier. - 2213-2317. ; 43
Relaterad länk:
https://umu.diva-por... (primary) (Raw object)
visa fler...
https://doi.org/10.1...
https://urn.kb.se/re...
https://doi.org/10.1...
http://kipublication...
visa färre...
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Nicotinamide adenine dinucleotide (NAD) is a REDOX cofactor and metabolite essential for neuronal survival. Glaucoma is a common neurodegenerative disease in which neuronal levels of NAD decline. We assess the effects of nicotinamide (a precursor to NAD) on retinal ganglion cells (the affected neuron in glaucoma) in normal physiological conditions and across a range of glaucoma relevant insults including mitochondrial stress and axon degenerative insults. We demonstrate retinal ganglion cell somal, axonal, and dendritic neuroprotection by nicotinamide in rodent models which represent isolated ocular hypertensive, axon degenerative, and mitochondrial degenerative insults. We performed metabolomics enriched for small molecular weight metabolites for the retina, optic nerve, and superior colliculus which demonstrates that ocular hypertension induces widespread metabolic disruption, including consistent changes to α-ketoglutaric acid, creatine/creatinine, homocysteine, and glycerophosphocholine. This metabolic disruption is prevented by nicotinamide. Nicotinamide provides further neuroprotective effects by increasing oxidative phosphorylation, buffering and preventing metabolic stress, and increasing mitochondrial size and motility whilst simultaneously dampening action potential firing frequency. These data support continued determination of the utility of long-term nicotinamide treatment as a neuroprotective therapy for human glaucoma.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Oftalmologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Ophthalmology (hsv//eng)

Nyckelord

Glaucoma
Metabolism
Metabolomics
Mitochondria
Nicotinamide
Retina
Retinal ganglion cell

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy