Control of growth factor binding and release in bisphosphonate functionalized hydrogels guides rapid diff erentiation of precursor cells in vitro

• An in situ cross-linkable hyaluronan hydrogel functionalized with bisphosphonate (BP) groups allows tunable release of bone morphogenetic protein-2 (BMP-2) determined by the amount of BP groups. The high affinity of matrix-anchored BP groups towards BMP-2 permits guided differentiation of entrapped progenitor cells in 3-D cultures.

Ämnesord

NATURVETENSKAP  -- Kemi -- Polymerkemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences -- Polymer Chemistry (hsv//eng)

Nyckelord

bone

hyaluronic acid

bisphosphonates

growth factor

delivery

stem cells

Kemi med inriktning mot materialkemi

Chemistry with specialization in Materials Chemistry

Kemi med inriktning mot polymerkemi

Chemistry with specialization in Polymer Chemistry

Biology with specialization in Molecular Biology

Biologi med inriktning mot molekylärbiologi

Publikations- och innehållstyp

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