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Association of Fata...
Association of Fatal and Nonfatal Cardiovascular Outcomes With 24-Hour Mean Arterial Pressure
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- Melgarejo, Jesus D. (författare)
- Univ Leuven, KU Leuven, Res Unit Hypertens & Cardiovasc Epidemiol, Dept Cardiovasc Sci, Campus Sint Rafael,Kapucijnenvoer 7,Box 7001, BE-3000 Leuven, Belgium.;Univ Zulia, Fac Med, Lab Neurosci, Maracaibo, Venezuela.
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- Yang, Wen-Yi (författare)
- Univ Leuven, KU Leuven, Res Unit Hypertens & Cardiovasc Epidemiol, Dept Cardiovasc Sci, Campus Sint Rafael,Kapucijnenvoer 7,Box 7001, BE-3000 Leuven, Belgium.;Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Sch Med, Dept Cardiol, Shanghai, Peoples R China.
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- Thijs, Lutgarde (författare)
- Univ Leuven, KU Leuven, Res Unit Hypertens & Cardiovasc Epidemiol, Dept Cardiovasc Sci, Campus Sint Rafael,Kapucijnenvoer 7,Box 7001, BE-3000 Leuven, Belgium.
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visa fler...
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- Li, Yan (författare)
- Shanghai Jiao Tong Univ, Ctr Epidemiol Studies & Clin Trials, Sch Med, Ruijin Hosp, Shanghai, Peoples R China.;Shanghai Jiao Tong Univ, Ctr Vasc Evaluat, Shanghai Inst Hypertens, Shanghai Key Lab Hypertens,Ruijin Hosp,Sch Med, Shanghai, Peoples R China.
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- Asayama, Kei (författare)
- Teikyo Univ, Dept Hyg & Publ Hlth, Sch Med, Tokyo, Japan.;Tohoku Inst Management Blood Pressure, Sendai, Miyagi, Japan.
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- Hansen, Tine W. (författare)
- Steno Diabet Ctr Copenhagen, Gentofte, Denmark.;Res Ctr Prevent & Hlth, Copenhagen, Capital Region, Denmark.
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- Wei, Fang-Fei (författare)
- Univ Leuven, KU Leuven, Res Unit Hypertens & Cardiovasc Epidemiol, Dept Cardiovasc Sci, Campus Sint Rafael,Kapucijnenvoer 7,Box 7001, BE-3000 Leuven, Belgium.
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- Kikuya, Masahiro (författare)
- Teikyo Univ, Dept Hyg & Publ Hlth, Sch Med, Tokyo, Japan.
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- Ohkubo, Takayoshi (författare)
- Teikyo Univ, Dept Hyg & Publ Hlth, Sch Med, Tokyo, Japan.;Tohoku Inst Management Blood Pressure, Sendai, Miyagi, Japan.
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- Dolan, Eamon (författare)
- Stroke & Hypertens Unit Blanchardstown, Dublin, Ireland.
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- Stolarz-Skrzypek, Katarzyna (författare)
- Jagiellonian Univ, Med Coll, Dept Cardiol Intervent Electrocardiol & Hypertens, Krakow, Poland.
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- Huang, Qi-Fang (författare)
- Shanghai Jiao Tong Univ, Ctr Epidemiol Studies & Clin Trials, Sch Med, Ruijin Hosp, Shanghai, Peoples R China.;Shanghai Jiao Tong Univ, Ctr Vasc Evaluat, Shanghai Inst Hypertens, Shanghai Key Lab Hypertens,Ruijin Hosp,Sch Med, Shanghai, Peoples R China.
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- Tikhonoff, Valerie (författare)
- Univ Padua, Dept Med, Padua, Italy.
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- Malyutina, Sofia (författare)
- Russian Acad Sci, Siberian Branch, Inst Internal & Prevent Med Internal & Prevent Me, Inst Cytol & Genet, Novosibirsk, Russia.
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- Casiglia, Edoardo (författare)
- Univ Padua, Dept Med, Padua, Italy.
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- Lind, Lars (författare)
- Uppsala universitet,Geriatrik
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- Sandoya, Edgardo (författare)
- Assoc Espanola Primera Socorros Mutuos, Montevideo, Uruguay.
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- Filipovsky, Jan (författare)
- Charles Univ Prague, Fac Med, Plzen, Czech Republic.
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- Gilis-Malinowska, Natasza (författare)
- Med Univ Gdansk, Dept Hypertens, Gdansk, Poland.
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- Narkiewicz, Krzysztof (författare)
- Med Univ Gdansk, Dept Hypertens, Gdansk, Poland.
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- Kawecka-Jaszcz, Kalina (författare)
- Jagiellonian Univ, Med Coll, Dept Cardiol Intervent Electrocardiol & Hypertens, Krakow, Poland.
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- Boggia, Jose (författare)
- Univ Repdbl, Hosp Clin, Ctr Nefrol, Montevideo, Uruguay.;Univ Repdbl, Hosp Clin, Dept Fisiopatol, Montevideo, Uruguay.
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- Wang, Ji-Guang (författare)
- Shanghai Jiao Tong Univ, Ctr Epidemiol Studies & Clin Trials, Sch Med, Ruijin Hosp, Shanghai, Peoples R China.;Shanghai Jiao Tong Univ, Ctr Vasc Evaluat, Shanghai Inst Hypertens, Shanghai Key Lab Hypertens,Ruijin Hosp,Sch Med, Shanghai, Peoples R China.
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- Imai, Yutaka (författare)
- Tohoku Inst Management Blood Pressure, Sendai, Miyagi, Japan.
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- Vanassche, Thomas (författare)
- Univ Leuven, KU Leuven, Dept Cardiovasc Sci, Ctr Mol & Vasc Biol, Leuven, Belgium.
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- Verhamme, Peter (författare)
- Univ Leuven, KU Leuven, Dept Cardiovasc Sci, Ctr Mol & Vasc Biol, Leuven, Belgium.
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- Janssens, Stefan (författare)
- Univ Hosp Leuven, Dept Internal Med, Div Cardiol, Leuven, Belgium.
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- O'Brien, Eoin (författare)
- Univ Coll Dublin, Conway Inst, Dublin, Ireland.
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- Maestre, Gladys E. (författare)
- Univ Zulia, Fac Med, Lab Neurosci, Maracaibo, Venezuela.;Univ Texas Rio Grande Valley, Sch Med, Dept Neurosci, Brownsville, TX USA.;Univ Texas Rio Grande Valley, Sch Med, Dept Human Genet, Brownsville, TX USA.;Univ Texas Rio Grande Valley, Alzheimers Dis Resource Ctr Minor Aging Res, Brownsville, TX USA.
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- Staessen, Jan A. (författare)
- Univ Leuven, KU Leuven, Res Unit Hypertens & Cardiovasc Epidemiol, Dept Cardiovasc Sci, Campus Sint Rafael,Kapucijnenvoer 7,Box 7001, BE-3000 Leuven, Belgium.;Res Inst Alliance Promot Prevent Med, Mechelen, Belgium.
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- Zhang, Zhen-Yu (författare)
- Univ Leuven, KU Leuven, Res Unit Hypertens & Cardiovasc Epidemiol, Dept Cardiovasc Sci, Campus Sint Rafael,Kapucijnenvoer 7,Box 7001, BE-3000 Leuven, Belgium.
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Univ Leuven, KU Leuven, Res Unit Hypertens & Cardiovasc Epidemiol, Dept Cardiovasc Sci, Campus Sint Rafael,Kapucijnenvoer 7,Box 7001, BE-3000 Leuven, Belgium;Univ Zulia, Fac Med, Lab Neurosci, Maracaibo, Venezuela. Univ Leuven, KU Leuven, Res Unit Hypertens & Cardiovasc Epidemiol, Dept Cardiovasc Sci, Campus Sint Rafael,Kapucijnenvoer 7,Box 7001, BE-3000 Leuven, Belgium.;Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Sch Med, Dept Cardiol, Shanghai, Peoples R China. (creator_code:org_t)
- Wolters Kluwer, 2021
- 2021
- Engelska.
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Ingår i: Hypertension. - : Wolters Kluwer. - 0194-911X .- 1524-4563. ; 77:1, s. 39-48
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Major adverse cardiovascular events are closely associated with 24-hour blood pressure (BP). We determined outcome-driven thresholds for 24-hour mean arterial pressure (MAP), a BP index estimated by oscillometric devices. We assessed the association of major adverse cardiovascular events with 24-hour MAP, systolic BP (SBP), and diastolic BP (DBP) in a population-based cohort (n=11 596). Statistics included multivariable Cox regression and the generalized R-2 statistic to test model fit. Baseline office and 24-hour MAP averaged 97.4 and 90.4 mm Hg. Over 13.6 years (median), 2034 major adverse cardiovascular events occurred. Twenty-four-hour MAP levels of <90 (normotension, n=6183), 90 to <92 (elevated MAP, n=909), 92 to <96 (stage-1 hypertension, n=1544), and >= 96 (stage-2 hypertension, n=2960) mm Hg yielded equivalent 10-year major adverse cardiovascular events risks as office MAP categorized using 2017 American thresholds for office SBP and DBP. Compared with 24-hour MAP normotension, hazard ratios were 0.96 (95% CI, 0.80-1.16), 1.32 (1.15-1.51), and 1.77 (1.59-1.97), for elevated and stage-1 and stage-2 hypertensive MAP. On top of 24-hour MAP, higher 24-hour SBP increased, whereas higher 24-hour DBP attenuated risk (P<0.001). Considering the 24-hour measurements, R-2 statistics were similar for SBP (1.34) and MAP (1.28), lower for DBP than for MAP (0.47), and reduced to null, if the base model included SBP and DBP; if the ambulatory BP indexes were dichotomized according to the 2017 American guideline and the proposed 92 mm Hg for MAP, the R-2 values were 0.71, 0.89, 0.32, and 0.10, respectively. In conclusion, the clinical application of 24-hour MAP thresholds in conjunction with SBP and DBP refines risk estimates.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- cardiovascular disease
- hypertension
- mean arterial pressure
- mortality
- oscillometry
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Melgarejo, Jesus ...
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Yang, Wen-Yi
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Thijs, Lutgarde
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Li, Yan
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Asayama, Kei
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Hansen, Tine W.
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visa fler...
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Wei, Fang-Fei
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Kikuya, Masahiro
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Ohkubo, Takayosh ...
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Dolan, Eamon
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Stolarz-Skrzypek ...
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Huang, Qi-Fang
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Tikhonoff, Valer ...
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Malyutina, Sofia
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Casiglia, Edoard ...
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Lind, Lars
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Sandoya, Edgardo
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Filipovsky, Jan
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Gilis-Malinowska ...
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Narkiewicz, Krzy ...
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Kawecka-Jaszcz, ...
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Boggia, Jose
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Wang, Ji-Guang
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Imai, Yutaka
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Vanassche, Thoma ...
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Verhamme, Peter
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Janssens, Stefan
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O'Brien, Eoin
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Maestre, Gladys ...
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Staessen, Jan A.
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Zhang, Zhen-Yu
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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Hypertension
- Av lärosätet
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Uppsala universitet