Platelet reactivity, fibrinogen and smoking.

• 40 young healthy male volunteers (20 habitual smokers and 20 non-smokers) were investigated with respect to platelet reactivity, plasma fibrinogen and coagulation factor VIII. Smokers had significantly lower systolic blood pressures and higher venous platelet counts. The results for ADP-induced platelet aggregation, plasma concentrations for the 2 alpha-granule proteins, beta-thromboglobulin and platelet factor 4, did not differ between the 2 study groups involved; nor was there any difference between serum thromboxane B2 formation or plasma factor VIII:C activity. However, as compared to non-smokers, plasma fibrinogen levels were significantly higher among the smokers.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

Blood Coagulation

Blood Platelets

physiology

Factor VIII

physiology

Fibrinogen

physiology

Humans

Male

Platelet Aggregation

Platelet Factor 4

blood

Smoking

Thromboxane B2

blood

beta-Thromboglobulin

blood

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)