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Rapidly changing my...
Rapidly changing myeloma epidemiology in the general population: Increased incidence, older patients, and longer survival
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- Turesson, Ingemar (författare)
- Lund University,Lunds universitet,Skåne University Hospital
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- Bjorkholm, M. (författare)
- Karolinska Institutet
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- Blimark, Cecilie (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Sahlgrenska University Hospital
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- Kristinsson, S. (författare)
- University of Iceland
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- Velez, R. (författare)
- Wake Forest University
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- Landgren, O. (författare)
- Memorial Sloan-Kettering Cancer Center
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(creator_code:org_t)
- 2018-06-25
- 2018
- Engelska.
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Ingår i: European Journal of Haematology. - : Wiley. - 0902-4441 .- 1600-0609. ; 101:2, s. 237-244
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Abstract
Ämnesord
Stäng
- The incidence of multiple myeloma is characterized by a steep increase with advancing age. Dramatic improvements in survival have been reported in clinical trials; however, elderly patients are generally underrepresented in these. The aims of this study are to review patterns of incidence and survival in multiple myeloma in the general population. We searched PubMed for population-based studies on trends in incidence and survival published between January 1, 2000 and June 30, 2017 and based on regional or national cancer registries and report the following results of the review. The age-adjusted incidence of multiple myeloma has increased during the second half of the twentieth century in some countries but remained stable in areas with high case ascertainment and access to universal medical care. The crude incidence is increasing globally due to an aging population. Survival rates have improved, and 5-year relative survival rates are now around 50% and over 60% in patients 65-70years or younger. Preliminary data suggest a 3-fold increase in the prevalence of multiple myeloma. We conclude that the number of multiple myeloma patients is increasing in the general population due to (i) aging populations and (ii) more patients living longer due to modern drugs.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- incidence
- multiple myeloma
- overall survival
- prevalence
- trends
- multiple-myeloma
- elderly-patients
- united-states
- dexamethasone
- lenalidomide
- age
- malignancies
- bortezomib
- patterns
- trends
- Hematology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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