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Cerebrospinal Fluid...
Cerebrospinal Fluid Biomarkers in Cerebral Amyloid Angiopathy.
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Banerjee, Gargi (author)
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Ambler, Gareth (author)
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Keshavan, Ashvini (author)
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Paterson, Ross W (author)
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Foiani, Martha S (author)
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Toombs, Jamie (author)
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Heslegrave, Amanda (author)
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Dickson, John C (author)
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Fraioli, Francesco (author)
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Groves, Ashley M (author)
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Lunn, Michael P (author)
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Fox, Nick C (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Schott, Jonathan M (author)
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Werring, David J (author)
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(creator_code:org_t)
- 2020
- 2020
- English.
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In: Journal of Alzheimer's disease : JAD. - 1875-8908. ; 74:4, s. 1189-1201
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https://doi.org/10.3...
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Abstract
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- There is limited data on cerebrospinal fluid (CSF) biomarkers in sporadic amyloid-β (Aβ) cerebral amyloid angiopathy (CAA).To determine the profile of biomarkers relevant to neurodegenerative disease in the CSF of patients with CAA.We performed a detailed comparison of CSF markers, comparing patients with CAA, Alzheimer's disease (AD), and control (CS) participants, recruited from the Biomarkers and Outcomes in CAA (BOCAA) study, and a Specialist Cognitive Disorders Service.We included 10 CAA, 20 AD, and 10 CS participants (mean age 68.6, 62.5, and 62.2 years, respectively). In unadjusted analyses, CAA patients had a distinctive CSF biomarker profile, with significantly lower (p<0.01) median concentrations of Aβ38, Aβ40, Aβ42, sAβPPα, and sAβPPβ. CAA patients had higher levels of neurofilament light (NFL) than the CS group (p<0.01), but there were no significant differences in CSF total tau, phospho-tau, soluble TREM2 (sTREM2), or neurogranin concentrations. AD patients had higher total tau, phospho-tau and neurogranin than CS and CAA groups. In age-adjusted analyses, differences for the CAA group remained for Aβ38, Aβ40, Aβ42, and sAβPPβ. Comparing CAA patients with amyloid-PET positive (n=5) and negative (n=5) scans, PET positive individuals had lower (p<0.05) concentrations of CSF Aβ42, and higher total tau, phospho-tau, NFL, and neurogranin concentrations, consistent with an "AD-like" profile.CAA has a characteristic biomarker profile, suggestive of a global, rather than selective, accumulation of amyloid species; we also provide evidence of different phenotypes according to amyloid-PET positivity. Further replication and validation of these preliminary findings in larger cohorts is needed.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Banerjee, Gargi
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Ambler, Gareth
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Keshavan, Ashvin ...
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Paterson, Ross W
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Foiani, Martha S
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Toombs, Jamie
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show more...
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Heslegrave, Aman ...
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Dickson, John C
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Fraioli, Frances ...
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Groves, Ashley M
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Lunn, Michael P
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Fox, Nick C
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Zetterberg, Henr ...
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Schott, Jonathan ...
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Werring, David J
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Journal of Alzhe ...
- By the university
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University of Gothenburg