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- Schneiderman, Justin F., 1979
(författare)
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On-scalp MEG with High-Tc SQUIDs
- 2022
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Ingår i: Flexible High Performance Magnetic Field Sensors, Labyt, E., Sander, T., Wakai, R. (eds). - Cham : Springer International Publishing. - 9783031053634 ; , s. 143-60
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Bokkapitel (refereegranskat)abstract
- High critical-temperature superconducting quantum interference devices (high-T c SQUIDs) were the first sensors to be used for on-scalp magnetoencephalography (MEG) recordings over a decade ago. Since that pioneering work, our group has advanced the theoretical motivation for further development of high-T c SQUID-based on-scalp MEG systems, focusing on where it can outperform the state-of-the-art, i.e., low-T c SQUID-based off-scalp MEG. That theory also provided a basis for practical system design and optimization that guided the construction of a seven-channel on-scalp MEG system. In parallel, we have experimentally verified theoretical predictions while also discovering specific advantages of high-T c SQUID-based on-scalp MEG in benchmarking style comparisons between it and the state-of-the-art. In the future, a full-head and flexible high-T c SQUID-based on-scalp MEG system may provide even more new knowledge regarding the human brain in health and disease.
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| 4. |
- Zhao, Jing Hua, et al.
(författare)
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Body vitamin D content and its relationship with body composition of children in Huairou district of Beijing
- 2010
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Ingår i: Zhonghua liu xing bing xue za zhi. - 0254-6450. ; 31:1, s. 34-38
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To analyze vitamin D concentration and its association with body composition of children in Huairou district of Beijing, to provide evidence for evaluation and improvement of nutritional status of vitamin D in children. METHODS: Totally, 381 children aged 7 - 11 years were recruited in Huairou district of Beijing (40.3 degrees N). Samples of overnight fasting venous blood (drawn between 0630 and 0900) were obtained in late March. Serum 25-hydroxyvitamin D [25(OH)D]concentration was determined by ELISA kits (IDS Ltd, UK). Body composition indices of the whole body, the distal and proximal forearm were measured using dual-energy X-ray absorptiometry (DEXA, Norland, USA). RESULTS: The average serum 25(OH)D concentration of all subjects was (44.4 +/- 12.5) nmol/L. The percentage of vitamin D insufficient [serum 25(OH)D
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- Stroganova, T. A., et al.
(författare)
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THE EFFECT OF PERIODICITY AND "VOWELNESS" OF A SOUND ON CORTICAL AUDITORY RESPONSES IN CHILDREN
- 2021
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Ingår i: Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova. - 0044-4677. ; 71:4, s. 563-577
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Tidskriftsartikel (refereegranskat)abstract
- The neural basis of speech decoding is of both fundamental and practical interest for many areas of neuroscience. The discovery of highly specialized areas of the temporal cortex, which perform acoustic analysis of vowels and the pitch of spectrally complex periodic sounds, opens the way for new directions in research on speech signal processing in healthy and diseased brain. Here, we sought to dissect the effects of periodicity and "vowelness" of a sound on the neural response of the auditory cortex in typically developing children aged 7-12 years. We hypothesized that although both of these properties are pertinent to speech vowels, their processing occurs at different levels of cortical ventral auditory stream. To test this hypothesis, we constructed a set of acoustic stimuli, manipulating their periodicity and 'vowelness' separately, and used magnetoencephalography in combination with individual brain models to assess the cortical topography and temporal dynamic of cortical sources, which respond selectively to either sounds' periodicity or to their 'vowelness'. We found that the early auditory responses (50-150 ms) were highly sensitive to both periodicity and 'vowelness' of a sound, although they were separable from each other in terms of response timing, source localization and hemispheric asymmetry. Our findings suggest that the separate neural networks are independently tuned for each of these properties of the speech sound, and that transformation of the respective acoustic properties into a speech feature take place at these earliest stages in the speech processing hierarchy. Our results may help to evaluate the role of specific neural deficits in the processing of low-level properties of speech sounds in language disorders.
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- Blennow, Kaj, 1958, et al.
(författare)
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- CSF neurogranin as a neuronal damage marker in CJD: A comparative study with AD
- 2019
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Ingår i: Journal of Neurology, Neurosurgery and Psychiatry. - : BMJ. - 0022-3050 .- 1468-330X. ; 90:8
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Tidskriftsartikel (refereegranskat)abstract
- - Objective: To investigate whether cerebrospinal fluid (CSF) neurogranin concentrations are altered in sporadic Creutzfeldt-Jakob disease (CJD), comparatively with Alzheimer's disease (AD), and associated with neuronal degeneration in brain tissue. Methods: CSF neurogranin, total tau, neurofilament light (NFL) and 14-3-3 protein were measured in neurological controls (NCs, n=64), AD (n=46) and CJD (n=81). The accuracy of neurogranin discriminating the three diagnostic groups was evaluated. Correlations between neurogranin and neurodegeneration biomarkers, demographic, genetic and clinical data were assessed. Additionally, neurogranin expression in postmortem brain tissue was studied. Results: Compared with NC, CSF neurogranin concentrations were increased in CJD (4.75 times of NC; p<0.001, area under curve (AUC), 0.96 (95% CI 0.93 to 0.99) and AD (1.94 times of NC; p<0.01, AUC 0.73, 95% CI 0.62 to 0.82), and were able to differentiate CJD from AD (p<0.001, AUC 0.85, 95% CI 0.78 to 0.92). CSF tau was increased in CJD (41 times of NC) and in AD (3.1 times of NC), both at p<0.001. In CJD, neurogranin positively correlated with tau (r=0.55, p<0.001) and was higher in 14-3-3-positivity (p<0.05), but showed no association with NFL (r=0.08, p=0.46). CJD-MM1/MV1 cases displayed higher neurogranin levels than VV2 cases. Neurogranin was increased at early CJD disease stages and was a good prognostic marker of survival time in CJD. In brain tissue, neurogranin was detected in the cytoplasm, membrane and postsynaptic density fractions of neurons, with reduced levels in AD, and more significantly in CJD, where they correlated with synaptic and axonal markers. Conclusions: Neurogranin is a new biomarker of prion pathogenesis with diagnostic and prognostic abilities, which reflects the degree of neuronal damage in brain tissue in a CJD subtype manner. © Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.
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- Constantinescu, Radu, 1966, et al.
(författare)
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Cerebrospinal fluid neurofilament light and tau protein as mortality biomarkers in parkinsonism
- 2019
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Ingår i: Acta Neurologica Scandinavica. - : Hindawi Limited. - 0001-6314 .- 1600-0404. ; 140:2, s. 147-156
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Tidskriftsartikel (refereegranskat)abstract
- - Background: Mortality is increased in parkinsonian disorders, moderately in Parkinson's disease (PD) but markedly in atypical parkinsonian disorders (APD), including multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD). Still, there are no reliable quantitative biomarkers for mortality. The cerebrospinal fluid (CSF) neurodegeneration biomarkers such as neurofilament light chain (NF-L), total tau (t-tau), and the tau pathology marker phosphorylated tau (p-tau) are related to mortality in other neurological disorders (eg, amyotrophic lateral sclerosis, Alzheimer's disease), but have not been investigated in this respect in parkinsonian disorders. Aims: To investigate the CSF biomarkers' (NF-L, t-tau, and p-tau) relationship to mortality in parkinsonian disorders. Methods: Demographic, mortality, and CSF data were collected from 68 PD and 83 APD patients. Survival analysis was conducted using Cox regression, with age at lumbar puncture, gender, diagnosis, and levels of CSF biomarkers as predictors. Results: NF-L in CSF was associated with increased mortality in synucleinopathies (PD, MSA; HR 3.698 [2.196-6.228, 95% confidence interval (CI)], P<0.001), in PSP (HR 2.767 [1.126-6.802 95% CI], P=0.027), and in the entire cohort (HR 1.661 [1.082-2.55, 95% CI], P=0.02). t-Tau in CSF was associated with increased mortality in PSP (HR 9.587 [1.143-80.418], P=0.037). p-Tau in CSF was associated with decreased mortality in synucleinopathies (HR 0.196 [0.041-0.929, 95% CI], P=0.040). Atypical parkinsonian disorders and tauopathies were associated with higher mortality (HR 8.798 [4.516-17.14, 95% CI] and HR 3.040 [1.904-4.854], respectively, P<0.001). Conclusion: NF-L and tau protein in CSF might be useful for mortality prognosis in patients with parkinsonian disorders and should be investigated in larger studies. © 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
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| 8. |
- Ericson, Mia, 1970, et al.
(författare)
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Different dopamine tone in ethanol high- and low-consuming Wistar rats
- 2020
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Ingår i: Addiction Biology. - : Wiley. - 1355-6215 .- 1369-1600. ; 2019
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Tidskriftsartikel (refereegranskat)abstract
- - Excessive alcohol use causes considerable morbidity and mortality worldwide. Changes in the mesolimbic dopamine system have been postulated as a neurobiological underpinning of excessive alcohol consumption, and recent research also suggests that the amino acid taurine plays a central role in ethanol-induced dopamine elevation. The aim of this study was to further outline the role of dopamine and taurine in regulating alcohol consumption. In this study, a choice between ethanol (20%) and water was administered to Wistar rats in an intermittent manner (three times/week) for seven consecutive weeks. In vivo microdialysis was used to explore baseline levels as well as ethanol-induced increases of extracellular dopamine and taurine, in the nucleus accumbens (nAc) of Wistar rats voluntarily consuming large or small amounts of ethanol. Basal levels of taurine were also measured in cerebrospinal fluid (CSF) and serum in a subset of rats. Ethanol-induced increases in nAc dopamine and taurine did not differ between alcohol-consuming and naïve rats. However, when categorized based on ethanol intake, rats consuming larger amounts of ethanol exhibited a lower dopamine tone in the nucleus accumbens and responded to ethanol with a slower elevation of extracellular taurine levels, as compared with low-consuming animals. Basal levels of taurine in nAc, CSF, or serum did not differ between ethanol high- and low-consuming rats. Our data support previous studies claiming an association between low endogenous dopamine levels and excessive alcohol intake. © 2019 Society for the Study of Addiction
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