| 1. |
- Olsson, H., et al.
(author)
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A biological marker, strongly associated with early oral contraceptive use, for the selection of a high risk group for premenopausal breast cancer
- 1986
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In: Medical Oncology and Tumor Pharmacotherapy. - 0736-0118. ; 3:2, s. 77-81
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Journal article (peer-reviewed)abstract
- In a population-based group of women, consecutively diagnosed, with premenopausal breast cancer there was a significant correlation between tumour size and plasma prolactin (r=0.30;P<0.004). The concentration of estrogen receptor was negatively correlated to tumour size (r=-0.17;P<0.09). There were no substantial correlations between tumour size and progesterone receptor, plasma progesterone or estradiol. Adjustments for menstrual cycle day and age did not alter the above findings. The ratio of plasma prolactin and estrogen receptor was significantly greater (P<0.037) for the group of the patients that had started using oral contraceptives before the age of 20 as compared with the other patients. Consequently, the tumour size was significantly greater in the group of early users (P<0.003). The findings indicate that breast tumours developing in previous early users of oral contraceptives have a low estrogen receptor concentration, while these patients have plasma prolactin. The tumour size is greater in early users indicating a poorer prognosis than other women with breast cancer. As early use of oral contraceptives increases, breast cancer risk and a high ratio of plasma prolactin and estrogen receptor concentration of the primary tumour characterize early oral contraceptive users the ratio may be a valuable marker for the breast cancer risk.
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| 2. |
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| 3. |
- Monti, M., et al.
(author)
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Microcalorimetric investigation of cell metabolism in tumour cells from patients with non‐Hodgkin lymphoma (NHL)
- 1986
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In: Scandinavian Journal of Haematology. - : Wiley. - 0036-553X. ; 36:4, s. 353-357
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Journal article (peer-reviewed)abstract
- The overall metabolism in tumour cells from 36 untreated patients with non‐Hodgkin lymphoma was evaluated by direct calorimetry. For 20 patients with lymphoma of high grade malignancy the median value of heat production rate per tumour cell was 3.9 pW and for 16 patients with low grade lymphomas the corresponding value was 2.8 pW. The difference between the two morphclogical groups is significant (p = 0.05). The median value of heat production rate per tumour cell from 13 patients who died within 2 yr after diagnosis was 4.0 pW. The corresponding value for 17 patients who have survived for more than 2 yr was 2.5 pW. The difference between the two groups is significant (p = 0.02). A high correlation was found between heat production rates in tumour cells and survival of the patients (p = 0.006).
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| 4. |
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| 5. |
- Olsson, H., et al.
(author)
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Early oral contraceptive use as a prognostic factor in breast cancer
- 1988
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In: Anticancer research. - 0250-7005. ; 8:1, s. 29-32
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Journal article (peer-reviewed)abstract
- The survival of 193 premenopausal breast cancer patients was investigated in relation to their history of early use of oral contraceptives. The women were born in 1939 or later and diagnosed in the southern health care region of Sweden. Women, who had started their oral contraceptive use (OC-use) before 20 years of age had a significantly lower survival rate as compared with those who had never used OC and late users (p = 0.02 and = 0.04 respectively, generalized Wilcoxon test). For women who started OC-use between 20 to 25 years of age, a tendency for a shorter survival was seen in comparison with women who had never used OC (p = 0.18). For all patients simultaneously, the relative risk adjusted for age at diagnosis increased for earlier OC-start. When only stages II and III were considered in a stratified multivariate model, a signficantly elevated risk was seen for early users of OC irrespective of age or of adjuvant treatment given. The estrogen and progesterone receptor concentrations of the primary tumor were significantly lower among early users (p = 0.001 and p = 0.05 respectively).
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| 6. |
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| 7. |
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| 8. |
- Olsson, H., et al.
(author)
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Permanent alterations induced in plasma prolactin and estrogen receptor concentration in benign and malignant tissue of women who started oral contraceptive use at an early age
- 1987
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In: Anticancer research. - 0250-7005. ; 7:4 B, s. 853-856
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Journal article (peer-reviewed)abstract
- In 65 young women undergoing curettage for benign utrine disorders a signicicant relationship was found between early oral contraceptive use (starting age<25 years) and a high ratio of ln plasma prolactin versus ln estrogen receptor concentration of the uterine mucosae (p<0.047, Mann-Whitneys U-test). Year of birth, age at menarche, age at first full term pregnancy, parity, menstrual cycle phase and duration of oral contraceptive use could not explain the results. Because similar results have previously been found for breast cancer patients using plasma prolactin and breast tumour estrogen receptor concentration, the findings indicate that early oral contraceptive use permanently alters plasma prolactin levels and estrogen receptor concentration, both in benign uterine tissue and in malignant breast tumours.
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| 9. |
- Olsson, H., et al.
(author)
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Relation between tumour size and plasma prolactin levels in premenopausal patients with breast carcinoma : A preliminary report
- 1985
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In: Acta Radiologica: Oncology. - : Informa UK Limited. - 0349-652X. ; 24:1, s. 57-59
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Journal article (peer-reviewed)abstract
- In thirty-one premenopausal patients with carcinoma of the breast the plasma prolactin was measured after mastectomy. A highly significant correlation between tumour size and plasma prolactin levels (p<0.002) was observed after adjustment for age at diagnosis and parity. At the time of the prolactin determination no clinical signs of metastatic disease were evident, suggesting that the prolactinc levels were unrelated to the tumour burden.
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| 10. |
- Olsson, H., et al.
(author)
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Risk of non-Hodgkin's lymphoma among men occupationally exposed to organic solvents
- 1988
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In: Scandinavian Journal of Work, Environment and Health. - : Scandinavian Journal of Work, Environment and Health. - 0355-3140 .- 1795-990X. ; 14:4, s. 246-251
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Journal article (peer-reviewed)abstract
- An occupational history of exposure to organic solvents, defined as daily occupational exposure for at least one year, was more common among 167 men with newly diagnosed non-Hodgkin's lymphoma than among 130 healthy referents from the general population (38 versus 14%). Categorization in five-year age groups gave 3.3 as a Mantel-Haenszel estimate of the odds ratio (95% CI 1.9-5.8). The odds ratio was 6.5 (95% CI 3.2-13.3) for localized supradiaphragmatic tumors and 2.3 (95% CI 1.3-4.3) for other lymphoma presentations. In a logistic model including age and organic solvent, phenoxy acid, and chlorophenol exposure, it could be shown that solvent exposure was an independent risk factor and that no important interaction occurred between the risk factors. With increasing duration of exposure there was a significantly increased risk of lymphoma, a finding implying a dose-response relationship. There was no significant difference in tumor histology between the exposed and unexposed patients. These findings support the concept that occupational exposure to organic solvents is a risk factor for non-Hodgkin's lymphoma. The results also confirm a strong association between such exposure and an supradiaphragmatic location of the lymphomas.
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