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Träfflista för sökning "AMNE:(MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology) srt2:(1985-1989);srt2:(1988);pers:(Mertens Fredrik)"

Sökning: AMNE:(MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology) > (1985-1989) > (1988) > Mertens Fredrik

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1.
  • JOHANSSON, BERTIL, et al. (författare)
  • Breakprone chromosome bands in fibroblasts from patients with non‐Hodgkin's lymphoma do not coincide with bands involved in primary rearrangements in non‐Hodgkin's lymphomas
  • 1988
  • Ingår i: Hereditas. - : Springer Science and Business Media LLC. - 0018-0661. ; 109:1, s. 131-137
  • Tidskriftsartikel (refereegranskat)abstract
    • The distribution of breakpoints in structural chromosome aberrations (chromatid and chromosome gaps, breaks, and exchanges) was studied in skin fibroblasts from 35 untreated patients with non‐Hodgkin's lymphoma (NHL) and 39 controls. A total of 227 aberrations in the NHL group and 260 in the control group could be assigned to specific chromosome bands. The distribution of breakpoints was nonrandom in both groups (p<0.001), with excessive breakage in 17 bands among the NHL patients and in 21 among the controls. Two of the hot spots in the NHL group (6q21,14q24) and three in the control group (2q33,6q21, 6q25) coincided with the 60 chromosome bands that are targets for primary chromosome abnormalities in NHL. We conclude that the chromosome bands involved in primary structural abnormalities in lymphoma cells are not constitutionally breakprone in NHL patients.
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2.
  • JOHANSSON, BERTIL, et al. (författare)
  • Normal frequency of structural chromosome aberrations in fibroblasts from patients with non‐Hodgkin's lymphoma
  • 1988
  • Ingår i: Hereditas. - : Springer Science and Business Media LLC. - 0018-0661. ; 109:2, s. 277-280
  • Tidskriftsartikel (refereegranskat)abstract
    • The incidence of chromosome aberrations, i.e., chromatid and chromosome gaps, breaks, and exchanges, was studied in cultured skin fibroblasts from 25 untreated patients with non‐Hodgkin's lymphoma (NHL) and 26 controls. The mean frequencies of aberrant cells, and gap, break, and gap+break events per 100 metaphases were 4.2, 1.9, 2.8, and 4.7 in the NHL group, and 5.1, 2.6, 3.2, and 5.8 in the control group. None of these parameters differed significantly between the groups, indicating that constitutional chromosomal instability is not related to the development of NHL. In the total material there was a significant (P<0.05) increase with age in the number of aberrant cells.
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  • Resultat 1-2 av 2
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tidskriftsartikel (2)
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refereegranskat (2)
Författare/redaktör
Johansson, Bertil (2)
Mertens, Fredrik (2)Ta bort avgränsningen
Heim, Sverre (2)
Mitelman, Felix (2)
Kristoffersson, Ulf (2)
Mandahl, Nils (2)
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Olsson, Håkan (1)
Olsson, Hakan (1)
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Lunds universitet (2)
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Engelska (2)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (2)
År
1988 (2)Ta bort avgränsningen

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