Sökning: AMNE:(MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology)
> (1995-1999)
> (1997)
> HOLMBERG L >
Mammographic screen...
Mammographic screening for breast cancer : What cancers do we find?
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- Nordén, T (författare)
- Department of Surgery, University Hospital, Uppsala, Sweden; Department of Cancer Epidemiology, University Hospital, Uppsala, Sweden; Department of Surgery, Kullbergska Hospital, Katrineholm, Sweden
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- Thurfjell, E (författare)
- Department of Diagnostic Radiology, University Hospital, Uppsala, Sweden
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- Hasselgren, Mikael, 1964- (författare)
- Department of Cancer Epidemiology, University Hospital, Uppsala, Sweden; Primary Health Care Centre, Skoghall, Sweden
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- Lindgren, A (författare)
- Department of Pathology, University Hospital, Uppsala, Sweden; Department of Pathology, Central Hospital, Falun, Sweden
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- Norgren, A (författare)
- Department of Pathology, University Hospital, Uppsala, Sweden; Department of Clinical Physiology, University Hospital, Uppsala, Sweden
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- Bergström, R (författare)
- Department of Statistics, Uppsala University, Uppsala, Sweden
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- Holmberg, L (författare)
- Department of Surgery, University Hospital, Uppsala, Sweden; Department of Cancer Epidemiology, University Hospital, Uppsala, Sweden
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(creator_code:org_t)
- Elsevier, 1997
- 1997
- Engelska.
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Ingår i: European Journal of Cancer. - : Elsevier. - 0959-8049 .- 1879-0852. ; 33:4, s. 624-628
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The aim of this study was to compare lymph node involvement of breast cancer cases detected at mammography screening with clinically-detected cases. During a 3-year period, 273 primary breast cancers were detected in a population-based screening programme, and 149 primary breast cancers were diagnosed clinically. Lymph node involvement was evaluated in univariate and multivariate logistic regression models correcting for tumour size, histological grade, steroid receptor status and DNA-ploidy. Patients with screen-detected cancers had a low relative risk of having lymph node metastases (univariate, OR = 0.31; 95% confidence interval = 0.19-0.52). In the multivariate logistic regression model, the relative risk was halved (OR = 0.47; 0.28-0.78). The reduced risk was more pronounced for women younger than 50 years of age compared to older women. The risk for screen-detected cases of having lymph node metastases at diagnosis was statistically significantly lower than for clinically-detected cases. The marked reduction, even when correcting for tumour size, makes it less likely that factors such as detection of clinically innocent tumours, length bias sampling or clinical symptoms related to axillary metastases can explain the whole difference. The results indicate at least part of the effect may be explained by tumour progression in the late preclinical detectable phase.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- breast neoplasms; mammography; mass screening
- Onkologi
- Oncology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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