2. |
- Pettersson, Ann, 1982-, et al.
(författare)
-
Nicotine induced modulation of SLURP-1 expression in human colon cancer cells.
- 2009
-
Ingår i: Autonomic neuroscience : basic & clinical. - : Elsevier BV. - 1872-7484 .- 1566-0702. ; 148:1-2, s. 97-100
-
Tidskriftsartikel (refereegranskat)abstract
- The secreted mammalian Ly-6/urokinase plasminogen activator receptor-related protein-1 (SLURP-1) is an endogenous ligand at the alpha 7 subunit of the nicotinic acetylcholine receptor (nAChR). SLURP-1 has anti-tumourigenic properties. In the current study, we demonstrate that the challenge of HT-29 human colon cancer cells with nicotine for 24 h to increase cell growth via the alpha 7nAChRs, caused a marked reduction of the protein expression of SLURP-1. We suggest that there is an interplay between acetylcholine and SLURP-1 in the HT-29 cells, both molecules serving as autocrine growth controlling ligands at the alpha 7nAChR, where acetylcholine regulates the release of SLURP-1.
|
|