| 1. |
- Söderberg, Johan, 1980-, et al.
(författare)
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Haemolysis index : an estimate of preanalytical quality in primary health care!
- 2009
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Ingår i: Clinical Chemistry and Laboratory Medicine. - 1434-6621 .- 1437-4331. ; 47:8, s. 940-944
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Tidskriftsartikel (refereegranskat)abstract
- Background: Haemolysis is usually caused by inadequate specimen collection or preanalytical handling, and is suggested to be a suitable indicator of preanalytical quality. We investigated the prevalence of detectable haemolysis in all routine venous blood samples to identify differences in preanalytical quality.Methods: Haemolysis index (HI) values were obtained from a Vitros 5,1 in the routine clinical chemistry laboratory for samples collected in primary health care centres (PHCs), nursing homes, and a hospital emergency department (ED). Haemolysis was defined as a HI ≥ 15 (detection limit).Results: Samples from the PHC with the highest prevalence of haemolysis were 6.1 times (95% confidence interval (CI) 4.0-9.2) more often haemolysed compared to the centre with the lowest prevalence. Of the samples collected in primary health care, 10.4% were haemolysed compared to 31.1% in the ED (p< 0.001). A notable difference in haemolysed samples was found between the ED section staffed by emergency medicine physicians and the section staffed by primary health care physicians (34.8% vs. 11.3%, p<0.001).Conclusions: The significant variation in haemolysis indices among the investigated units is likely to reflect varying preanalytical conditions. The HI is a valuable tool for estimation and follow-up of preanalytical quality in primary health care.
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| 2. |
- Lippi, Giuseppe, et al.
(författare)
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Preanalytical quality improvement : in quality we trust
- 2013
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Ingår i: Clinical Chemistry and Laboratory Medicine. - : Walter de Gruyter. - 1434-6621 .- 1437-4331. ; 51:1, s. 229-241
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Tidskriftsartikel (refereegranskat)abstract
- Total quality in laboratory medicine should be defined as the guarantee that each activity throughout the total testing process is correctly performed, providing valuable medical decision-making and effective patient care. In the past decades, a 10-fold reduction in the analytical error rate has been achieved thanks to improvements in both reliability and standardization of analytical techniques, reagents, and instrumentation. Notable advances in information technology, quality control and quality assurance methods have also assured a valuable contribution for reducing diagnostic errors. Nevertheless, several lines of evidence still suggest that most errors in laboratory diagnostics fall outside the analytical phase, and the pre- and postanalytical steps have been found to be much more vulnerable. This collective paper, which is the logical continuum of the former already published in this journal 2 years ago, provides additional contribution to risk management in the preanalytical phase and is a synopsis of the lectures of the 2nd European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)-Becton Dickinson (BD) European Conference on Preanalytical Phase meeting entitled "Preanalytical quality improvement: in quality we trust" (Zagreb, Croatia, 1-2 March 2013). The leading topics that will be discussed include quality indicators for preanalytical phase, phlebotomy practices for collection of blood gas analysis and pediatric samples, lipemia and blood collection tube interferences, preanalytical requirements of urinalysis, molecular biology hemostasis and platelet testing, as well as indications on best practices for safe blood collection. Auditing of the preanalytical phase by ISO assessors and external quality assessment for preanalytical phase are also discussed.
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| 3. |
- Grankvist, Kjell, et al.
(författare)
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Laboratoriernas verksamhet
- 2018. - 10
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Ingår i: Laurells Klinisk kemi i praktisk medicin. - Lund : Studentlitteratur AB. - 9789144119748 ; , s. 13-30
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Bokkapitel (refereegranskat)
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| 4. |
- Hammarsten, Ola, et al.
(författare)
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Tolkning av analysresultat
- 2018. - 10
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Ingår i: Laurells Klinisk kemi i praktisk medicin. - Lund : Studentlitteratur AB. - 9789144119748 ; , s. 31-53
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Bokkapitel (refereegranskat)
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| 5. |
- Simundic, Ana-Maria, et al.
(författare)
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Colour coding for blood collection tube closures - a call for harmonisation
- 2015
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Ingår i: Clinical Chemistry and Laboratory Medicine. - : Walter de Gruyter GmbH. - 1434-6621 .- 1437-4331. ; 53:3, s. 371-376
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Tidskriftsartikel (refereegranskat)abstract
- At least one in 10 patients experience adverse events while receiving hospital care. Many of the errors are related to laboratory diagnostics. Efforts to reduce laboratory errors over recent decades have primarily focused on the measurement process while pre-and postanalytical errors including errors in sampling, reporting and decision-making have received much less attention. Proper sampling and additives to the samples are essential. Tubes and additives are identified not only in writing on the tubes but also by the colour of the tube closures. Unfortunately these colours have not been standardised, running the risk of error when tubes from one manufacturer are replaced by the tubes from another manufacturer that use different colour coding. EFLM therefore supports the worldwide harmonisation of the colour coding for blood collection tube closures and labels in order to reduce the risk of pre-analytical errors and improve the patient safety.
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| 6. |
- Grankvist, Kjell, et al.
(författare)
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Preanalytical aspects on short- and long-term storage of serum and plasma
- 2019
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Ingår i: Diagnosis. - : Walter de Gruyter. - 2194-8011 .- 2194-802X. ; 6:1, s. 51-56
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Forskningsöversikt (refereegranskat)abstract
- Following an ordered clinical chemistry plasma/serum test, ideally the venous blood specimen is adequately collected at a health care facility, then swiftly transported to and readily handled, analyzed and sometimes interpreted at a clinical chemistry laboratory followed by a report of the test result to the ordering physician to finally handle the result. However, often there are practical as well as sample quality reasons for short-or long-term storage of samples before and after analysis. If there are specific storage needs, the preanalytical handling practices are specified in the laboratory's specimen collection instructions for the ordered test analyte. Biobanking of specimens over a very long time prior to analysis includes an often neglected preanalytical challenge for preserved quality of the blood specimen and also involves administrative and additional practical handling aspects (specified in a standard operating procedure SOP) when demands and considerations from academic, industry, research organizations and authorities are included. This short review highlights some preanalytical aspects of plasma/serum short-and long-term storage that must be considered by clinicians, laboratory staff as well as the researchers.
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| 7. |
- Theodorsson, Elvar, et al.
(författare)
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Anemier
- 2012. - 9
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Ingår i: Laurells klinisk kemi i praktisk medicin. - Lund : Studentlitteratur. - 9789144047874 ; , s. 211-280
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Bokkapitel (refereegranskat)
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| 8. |
- Theodorsson, Elvar, et al.
(författare)
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Laboratoriernas verksamhet
- 2012. - 9
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Ingår i: Laurells klinisk kemi i praktisk medicin. - Lund : Studentlitteratur. - 9789144047874 ; , s. 9-22
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Bokkapitel (refereegranskat)
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| 9. |
- Theodorsson, Elvar, et al.
(författare)
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Tolkning av analysresultat
- 2012. - 9
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Ingår i: Laurells klinisk kemi i praktisk medicin. - Lund : Studentlitteratur. - 9789144047874 ; , s. 23-51
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Bokkapitel (refereegranskat)
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| 10. |
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