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- Kristenson, Margareta, et al.
(författare)
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The role of saliva cortisol measurements in health and disease : A matter of theory and methodology
- 2010
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Ingår i: International Journal of Behavioral Medicine. - : Springer. - 1070-5503 .- 1532-7558. ; , s. S206-S206
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Konferensbidrag (refereegranskat)abstract
- Over the last decade, the technique of using ambulatory salivary sampling has become increasingly popular in field research and clinical studies. The non-invasive method is easy to administer and analyze and allows implmentation in large scale study designs. However, this large interest in the use of salivary cortisol measurement is paralleled with frustrations on opposing results. This presentation is based on a critical evaluation of the existing literature on salivary cortisol, aiming to evaluate the utility of salivary cortisol as a biomarker in various settings and how we can understand cortisol reactivity using evidence of experiences from different study designs. The work is compiled by the Scandinavian Stress and Cortisol Network, a network financed by the Swedish Research Council, and one main question asked was: is it possible that different results of studies involving cortisol assessments are functions of differences in the theoretical assumptions made and methods used. In particular, the symposium will focus on how the many different ways of evaluating levels and dynamics of salivary cortisol (i. e. with regard to time points of assessment and different algorithms based on multiple time points) may have an impact on the interpretation of cortisol measurements in various contexts. Salivary cortisol has been studied in relation to the following topics: demographic variables, psychosocial work environment, psychosocial resources (e.g. mastery) and outcomes (e.g. burnout), sleep quality, biological markers (markers of cardivascular risk, inflammation and metabolism) and somatic outcome.
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- Modin, Bitte, et al.
(författare)
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The impact of early twentieth century illegitimacy across three generations : Longevity and intergenerational health correlates.
- 2009
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Ingår i: Social Science and Medicine. - : Elsevier BV. - 0277-9536 .- 1873-5347. ; 68:9, s. 1633-1640
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Tidskriftsartikel (refereegranskat)abstract
- This study contributes to the understanding of how social mortality patterns are reproduced across generations by documenting associations of women's marital status at childbirth in the beginning of last century with selected health indicators across three subsequent generations of their offspring, and by highlighting a special set of plausible mechanisms linked to this particular event in history. We use the Multigenerational Uppsala Birth Cohort Study (UBCoS) database consisting of 12,168 individuals born at Uppsala University Hospital in 1915-1929 (UG1), their children (UG2) and grandchildren (UG3). Results showed that men and women born outside wedlock (BOW) in early twentieth century Sweden were at an increased risk of adult mortality compared to those who were born in wedlock (BIW), and the men were also significantly less likely to reach their 80th birthday. The question of childhood social disadvantage and its long-term consequences for health is then taken one step further by examining their offspring in two subsequent generations in terms of four specific anthropometric and psychological outcomes at the time of military conscription, all known to predict disease and mortality later in life. Results showed that sons of men BOW as well as sons and grandsons of women BOW had significantly lower psychological functioning and cognitive ability. Regarding body mass index and height, however, significant associations were found only among descendants of men BOW. The anthropometric and psychological disadvantages found among descendents of individuals BOW were partly mediated by their social class background. The four outcomes observed early in the lives of UG2s and UG3s do in fact constitute early health determinants, each potentially influencing longevity and mortality risk in these generations. We conclude that the social disadvantage imposed on those BOW in early twentieth century Sweden appears to be reproduced as a health disadvantage in their children and grandchildren, with likely consequences for mortality among these.
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