| 1. |
- Haraldsdottir, Sigurdis, et al.
(författare)
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Krabbamein í ristli og endaþarmi - yfirlitsgrein
- 2014
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Ingår i: Laeknabladid. - 0023-7213. ; 100:2, s. 75-82
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Forskningsöversikt (refereegranskat)abstract
- Colorectal cancer is the third most common cancer in the Western hemisphere and the incidence increases with increasing age. Most colorectal cancers are localized with or without lymph node metastases. Up to 20% of patients present with metastatic disease, most commonly to the liver. Surgery is the only curative therapy for localized colorectal cancer and adjuvant chemotherapy is usually recommended for patients with lymph node metastases. Surgery, radiation therapy and chemotherapy are the key components of rectal cancer therapy. Selected patients with recurrent and metastatic disease can be salvaged with surgery but chemotherapy remains the mainstay of therapy for advanced colorectal cancer. Substantial progress has been observed in the treatment of metastatic colorectal cancer in recent years.
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| 2. |
- Birgisson, Helgi, et al.
(författare)
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Skimun fyrir krabbameinum í ristli og endaþarmi : Yfirlitsgrein um nýgengi, dánartíðni, kostnað og árangur
- 2021
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Ingår i: Laeknabladid. - : LAEKNAFELAG ISLANDS-ICELANDIC MEDICAL ASSOC. - 0023-7213 .- 1670-4959. ; 107:9, s. 398-405
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Forskningsöversikt (refereegranskat)abstract
- In this article the incidence and mortality for cancer of the colon and rectum in Iceland is discussed. The two most common screening methods, faecal immunochemical test (FIT) and colonoscopy are compared and an estimate of cost and benefits for the Icelandic society will be made. The incidence of cancer of the colon and rectum has been increasing in Iceland in last decades but mortality has decreased and survival improved. However, more individuals die from cancer of the colon and rectum than from both breast-and cervical cancer added together. It is likely that screening for cancer of the colon and rectum, could prevent at least 6 of the 28 deaths related to those cancers, occurring yearly in Iceland in screening age, given a screening ages of 50-74 years. The extra cost for the Icelandic community due to the implementation of screening for cancer of the colon and rectum will be acceptable due to the lower cost of simpler treatments, lower cancer incidence and reduced mortality.
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| 3. |
- Vidarsdottir, Halla, et al.
(författare)
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Kirtilkrabbamein í botnlanga á islandi 1990-2009 -- lýdgrundud rannsókn
- 2011
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Ingår i: Laeknabladid. - 0023-7213. ; 97:10, s. 42-537
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: Adenocarcinoma of the appendix is less than 0.5% of all gastrointestinal cancers. The aim of this study was to analyse the incidence, symptoms, pathology and treatment of appendiceal adenocarcinoma in a well defined cohort as well as the prognosis of the patients.MATERIALS AND METHODS: This is a retrospective study on all patients diagnosed with adenocarcinoma of the appendix in Iceland from 1990-2009. Information on epidemiological factors, survival and treatment was collected. All histological material was reviewed. Overall survival was estimated with median follow up of 15 months (range, 0-158).RESULTS: A total of 22 patients were diagnosed with appendiceal adenocarinoma in the study period (median age 63 yrs, range: 30-88, 50% males). Age-standardized incidence was 0.4/100,000/year. The most common symptom was abdominal pain (n=10). Eight patients had clinical signs of appendicitis. Most patients were diagnosed at operation or at pathological examination but one patient was diagnosed at autopsy. Five patients had an appendectomy and 11 a right hemicolectomy. One patient was not operated on and in three patients only a biopsy was taken. Twelve patients had chemotherapy and seven of them for metastatic disease. Eight patients had adenocarcinoma, seven mucinous adenocarcinoma, three signet ring adenocarcinoma, one mixed goblet cell carcinoid and mucinous adenocarcinoma,one mixed adenocarcinoma and signet ring adenocarcinoma and two a mucinous tumour of unknown malignant potential. In eight cases the tumor originated in adenoma. Most of the patients had a stage IV disease (n=13), three stage III, three stage II and three stage I. Operative mortality was 4.8% (n=1). Disease specific five year survival was 54% but overall five year survival was 44% respectively.CONCLUSION: Adenocarcinoma of the appendix is a rare disease. No patients were diagnosed pre-operatively. Over half of the patients presented with stage IV disease.
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| 4. |
- Vidarsdóttir, Halla, et al.
(författare)
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Skurdmedferd lungnameinvarpa - yfirlitsgrein um ábendingar og árangur medferdar
- 2013
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Ingår i: Laeknabladid. - 0023-7213. ; 99:3, s. 43-137
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Tidskriftsartikel (refereegranskat)abstract
- In Iceland every third individual is diagnosed with malignant disease; cancer being the cause of death in one out of four individuals with only cardiovascular diseases being more common cause of death. Approximately one third of cancer patients are diagnosed with lung metastases making the lungs one of the most common metastatic site. In some of these patients a metastasectomy is a treatment option with the intention of improving survival. In this evidence-based review, the indications and outcome of pulmonary metastasectomy are discussed. This review is aimed at doctors within different specialties where Icelandic studies on pulmonary metastasectomy are referred to.
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