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> Lammi Mikko 1961 >
Abnormal expression...
Abnormal expression of chondroitin sulfate sulfotransferases in the articular cartilage of pediatric patients with Kashin-Beck disease
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- Lei, Jian (författare)
- School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China
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- Yan, Siqi (författare)
- Shenzhen Institute, Xi'an Jiaotong University, China; Department of Ophthalmology, The First Affiliated Hospital, Health Science Center of Xi'an Jiaotong University, Xi'an, China
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- Zhou, Yuan (författare)
- School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China
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- Wang, Liyun (författare)
- School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China; Shenzhen Institute, Xi'an Jiaotong University, Shenzhen, China
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- Zhang, Jinghua (författare)
- School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China
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- Guo, Xiong (författare)
- School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China
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- Lammi, Mikko, 1961- (författare)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, P. R. China,Chondrogenic and Osteogenic Differentiation
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- Han, Jing (författare)
- Shenzhen Institute, Xi'an Jiaotong University, Shenzhen, China
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- Qu, Chengjuan, 1967- (författare)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Chondrogenic and Osteogenic Differentiation
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(creator_code:org_t)
- 2019-12-16
- 2020
- Engelska.
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Ingår i: Histochemistry and Cell Biology. - : Springer Science and Business Media LLC. - 0948-6143 .- 1432-119X. ; 153:3, s. 153-164
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The objective of this study is to investigate the expression of enzymes involved in the sulfation of articular cartilage from proximal metacarpophalangeal (PMC) joint cartilage and distal metacarpophalangeal (DMC) joint cartilage in children with Kashin-Beck disease (KBD). The finger cartilage samples of PMC and DMC were collected from KBD and normal children aged 5-14 years old. Hematoxylin and eosin staining as well as immunohistochemical staining were used to observe the morphology and quantitate the expression of carbohydrate sulfotransferase 3 (CHST-3), carbohydrate sulfotransferase 12 (CHST-12), carbohydrate sulfotransferase 13 (CHST-13), uronyl 2-O-sulfotransferase (UST), and aggrecan. In the results, the numbers of chondrocyte decreased in all three zones of PMC and DMC in the KBD group. Less positive staining cells for CHST-3, CHST-12, CHST-13, UST, and aggrecan were observed in almost all three zones of PMC and DMC in KBD. The positive staining cell rates of CHST-12 were higher in superficial and middle zones of PMC and DMC in KBD, and a significantly higher rate of CHST-13 was observed only in superficial zone of PMC in KBD. In conclusion, the abnormal expression of chondroitin sulfate sulfotransferases in chondrocytes of KBD children may provide an explanation for the cartilage damage, and provide therapeutic targets for the treatment.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- Children’s cartilage
- Chondroitin sulfate
- Kashin–Beck disease
- Selenium deficiency
- Sulfation
- Sulfotransferases
- molecular medicine (medical sciences)
- molekylär medicin (medicinska vetenskaper)
- reumatologi
- rheumatology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Lei, Jian
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Yan, Siqi
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Zhou, Yuan
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Wang, Liyun
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Zhang, Jinghua
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Guo, Xiong
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Lammi, Mikko, 19 ...
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Han, Jing
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Qu, Chengjuan, 1 ...
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Umeå universitet