SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "AMNE:(NATURVETENSKAP Biologi Biokemi och molekylärbiologi) ;pers:(Hellman Lars)"

Sökning: AMNE:(NATURVETENSKAP Biologi Biokemi och molekylärbiologi) > Hellman Lars

  • Resultat 1-10 av 37
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  •  
2.
  •  
3.
  •  
4.
  • Akula, Srinivas, et al. (författare)
  • Quantitative Analysis of the Transcriptome of Two Commonly Used Human Monocytic Cell Lines-THP-1 and Mono Mac 6-Reveals Their Arrest during Early Monocyte/Neutrophil Differentiation
  • 2022
  • Ingår i: International Journal of Molecular Sciences. - : MDPI AG. - 1661-6596 .- 1422-0067. ; 23:10
  • Tidskriftsartikel (refereegranskat)abstract
    • Cell lines of monocyte/macrophage origin are often used as model systems to study monocyte/macrophage biology. A relevant question is how similar these cell lines are to their in vivo counterparts? To address this issue, we performed a detailed analysis of the transcriptome of two commonly used human monocyte/macrophage cell lines, Mono Mac 6 and THP-1. Both of these cell lines originate from leukemic cells with myelo-monocytic characteristics. We found that both Mono Mac 6 and THP-1 represent cells of very immature origin. Their transcriptomes show more similarities to immature neutrophils than cells of the monocyte/macrophage lineage. They express significant levels of N-elastase, proteinase 3, cathepsin G, and azurocidin but very low levels of CD14, ficolin, and complement factor P. All major MHC class II genes are also expressed at low levels. They show high levels of lysozyme and low levels of one of the immunoglobulin Fc receptors, FCGRIIA, which is characteristic of both neutrophils and monocytes. THP-1, but not Mono Mac 6, also expresses the high-affinity receptor for IgG, FCGRIA. Both cell lines lack the expression of the connective tissue components fibronectin, proteoglycan 4, and syndecan 3, which are characteristics of tissue macrophages but are absent in blood monocytes, indicating that they originate from bone marrow precursors and not yolk sac-derived hematopoietic cells. Both of these cell lines seem, therefore, to represent cells arrested during early myelo-monocytic development, at a branch point between neutrophil and monocyte differentiation. Their very immature phenotype indicates that great care should be taken when using these cell lines as models for normal monocyte/macrophage biology.
  •  
5.
  •  
6.
  •  
7.
  •  
8.
  •  
9.
  •  
10.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 37
Typ av publikation
tidskriftsartikel (34)
forskningsöversikt (2)
doktorsavhandling (1)
Typ av innehåll
refereegranskat (36)
övrigt vetenskapligt/konstnärligt (1)
Författare/redaktör
Akula, Srinivas (16)
Fu, Zhirong (15)
Thorpe, Michael (12)
Belov, Katherine (5)
de Garavilla, Lawren ... (5)
visa fler...
Kervinen, Jukka (5)
Olsson, Anna-Karin (4)
Wernersson, Sara (3)
Ryu, Jinhye (3)
Cooper, D.W. (3)
Hallgren, Jenny (2)
Åbrink, Magnus (2)
Andersson, Mattias K ... (2)
Karlson, Ulrika (2)
Aveskogh, Maria (2)
Aybay, Erdem (2)
Miller, Robert D (2)
Chahal, Gurdeep (2)
Johansson, Jeannette (2)
Munday, Barry (2)
Vernersson, Molly (2)
Abrink, Magnus (1)
Pejler, Gunnar (1)
Welinder, Charlotte (1)
Lara, Sandra (1)
Alvarado-Vazquez, Pe ... (1)
Mendez-Enriquez, Eri ... (1)
Braasch, Ingo (1)
Ledin, Anna (1)
Pemberton, Alan D. (1)
Miller, Hugh R. P. (1)
Enoksson, Mattias (1)
Roy, Ananya (1)
Elkhalifa, Mamoun (1)
Bachert, Claus (1)
Zenger, K.R. (1)
Lam, MKP (1)
Colgan, DJ. (1)
Berglund, Petter (1)
Walls, Andrew F. (1)
Alemayehu, Rahel (1)
Fröman, Gunnar (1)
Qiao, Chang (1)
Reimer, Jenny (1)
Vandenabeele, Peter (1)
Korkmaz, Brice (1)
Jegot, Gwenhael (1)
Lau, Laurie C. (1)
Pitois, Elodie (1)
visa färre...
Lärosäte
Uppsala universitet (37)
Sveriges Lantbruksuniversitet (5)
Lunds universitet (1)
Karolinska Institutet (1)
Språk
Engelska (37)
Forskningsämne (UKÄ/SCB)
Naturvetenskap (37)
Medicin och hälsovetenskap (6)
Lantbruksvetenskap (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy