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Sökning: AMNE:(NATURVETENSKAP Fysik Astronomi, astrofysik och kosmologi) > Medicin och hälsovetenskap

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1.
  • Gerlee, Philip, 1980, et al. (författare)
  • Scientific Models : Red Atoms, White Lies and Black Boxes in a Yellow Book
  • 2016
  • Bok (övrigt vetenskapligt/konstnärligt)abstract
    • A zebrafish, the hull of a miniature ship, a mathematical equation and a food chain - what do these things have in common? They are examples of models used by scientists to isolate and study particular aspects of the world around us. This book begins by introducing the concept of a scientific model from an intuitive perspective, drawing parallels to mental models and artistic representations. It then recounts the history of modelling from the 16th century up until the present day. The iterative process of model building is described and discussed in the context of complex models with high predictive accuracy versus simpler models that provide more of a conceptual understanding. To illustrate the diversity of opinions within the scientific community, we also present the results of an interview study, in which ten scientists from different disciplines describe their views on modelling and how models feature in their work. Lastly, it includes a number of worked examples that span different modelling approaches and techniques. It provides a comprehensive introduction to scientific models and shows how models are constructed and used in modern science. It also addresses the approach to, and the culture surrounding modelling in different scientific disciplines. It serves as an inspiration for model building and also facilitates interdisciplinary collaborations by showing how models are used in different scientific fields. The book is aimed primarily at students in the sciences and engineering, as well as students at teacher training colleges but will also appeal to interested readers wanting to get an overview of scientific modelling in general and different modelling approaches in particular.
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2.
  • Gerlee, Philip, 1980, et al. (författare)
  • Scientific Models
  • 2016
  • Bok (övrigt vetenskapligt/konstnärligt)abstract
    • A zebrafish, the hull of a miniature ship, a mathematical equation and a food chain - what do these things have in common? They are examples of models used by scientists to isolate and study particular aspects of the world around us. This book begins by introducing the concept of a scientific model from an intuitive perspective, drawing parallels to mental models and artistic representations. It then recounts the history of modelling from the 16th century up until the present day. The iterative process of model building is described and discussed in the context of complex models with high predictive accuracy versus simpler models that provide more of a conceptual understanding. To illustrate the diversity of opinions within the scientific community, we also present the results of an interview study, in which ten scientists from different disciplines describe their views on modelling and how models feature in their work. Lastly, it includes a number of worked examples that span different modelling approaches and techniques. It provides a comprehensive introduction to scientific models and shows how models are constructed and used in modern science. It also addresses the approach to, and the culture surrounding modelling in different scientific disciplines. It serves as an inspiration for model building and also facilitates interdisciplinary collaborations by showing how models are used in different scientific fields. The book is aimed primarily at students in the sciences and engineering, as well as students at teacher training colleges but will also appeal to interested readers wanting to get an overview of scientific modelling in general and different modelling approaches in particular.
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3.
  • Narvaez, Omar, et al. (författare)
  • Nonparametric distributions of tensor-valued Lorentzian diffusion spectra for model-free data inversion in multidimensional diffusion MRI
  • 2024
  • Ingår i: Journal of Chemical Physics. - 1089-7690 .- 0021-9606. ; 161:8
  • Tidskriftsartikel (refereegranskat)abstract
    • Magnetic resonance imaging (MRI) is the method of choice for noninvasive studies of micrometer-scale structures in biological tissues via their effects on the time- and frequency-dependent (restricted) and anisotropic self-diffusion of water. While new designs of time-dependent magnetic field gradient waveforms have enabled disambiguation between different aspects of translational motion that are convolved in traditional MRI methods relying on single pairs of field gradient pulses, data analysis for complex heterogeneous materials remains a challenge. Here, we propose and demonstrate nonparametric distributions of tensor-valued Lorentzian diffusion spectra, or “D(ω) distributions,” as a general representation with sufficient flexibility to describe the MRI signal response from a wide range of model systems and biological tissues investigated with modulated gradient waveforms separating and correlating the effects of restricted and anisotropic diffusion.
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4.
  • Checinska, Aleksandra, et al. (författare)
  • Microbiomes of the dust particles collected from the International Space Station and Spacecraft Assembly Facilities
  • 2015
  • Ingår i: Microbiome. - : Springer Science and Business Media LLC. - 2049-2618. ; 3
  • Tidskriftsartikel (refereegranskat)abstract
    • Background - The International Space Station (ISS) is a unique built environment due to the effects of microgravity, space radiation, elevated carbon dioxide levels, and especially continuous human habitation. Understanding the composition of the ISS microbial community will facilitate further development of safety and maintenance practices. The primary goal of this study was to characterize the viable microbiome of the ISS-built environment. A second objective was to determine if the built environments of Earth-based cleanrooms associated with space exploration are an appropriate model of the ISS environment. Results - Samples collected from the ISS and two cleanrooms at the Jet Propulsion Laboratory (JPL, Pasadena, CA) were analyzed by traditional cultivation, adenosine triphosphate (ATP), and propidium monoazide–quantitative polymerase chain reaction (PMA-qPCR) assays to estimate viable microbial populations. The 16S rRNA gene Illumina iTag sequencing was used to elucidate microbial diversity and explore differences between ISS and cleanroom microbiomes. Statistical analyses showed that members of the phyla Actinobacteria, Firmicutes, and Proteobacteria were dominant in the samples examined but varied in abundance. Actinobacteria were predominant in the ISS samples whereas Proteobacteria, least abundant in the ISS, dominated in the cleanroom samples. The viable bacterial populations seen by PMA treatment were greatly decreased. However, the treatment did not appear to have an effect on the bacterial composition (diversity) associated with each sampling site. Conclusions - The results of this study provide strong evidence that specific human skin-associated microorganisms make a substantial contribution to the ISS microbiome, which is not the case in Earth-based cleanrooms. For example, Corynebacterium and Propionibacterium (Actinobacteria) but not Staphylococcus (Firmicutes) species are dominant on the ISS in terms of viable and total bacterial community composition. The results obtained will facilitate future studies to determine how stable the ISS environment is over time. The present results also demonstrate the value of measuring viable cell diversity and population size at any sampling site. This information can be used to identify sites that can be targeted for more stringent cleaning. Finally, the results will allow comparisons with other built sites and facilitate future improvements on the ISS that will ensure astronaut health.
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5.
  • Van Grootel, V., et al. (författare)
  • A search for transiting planets around hot subdwarfs: I. Methods and performance tests on light curves from Kepler, K2, TESS, and CHEOPS
  • 2021
  • Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 650
  • Tidskriftsartikel (refereegranskat)abstract
    • Context. Hot subdwarfs experienced strong mass loss on the red giant branch (RGB) and are now hot and small He-burning objects. These stars constitute excellent opportunities for addressing the question of the evolution of exoplanetary systems directly after the RGB phase of evolution. Aims. In this project we aim to perform a transit survey in all available light curves of hot subdwarfs from space-based telescopes (Kepler, K2, TESS, and CHEOPS) with our custom-made pipeline SHERLOCK in order to determine the occurrence rate of planets around these stars as a function of orbital period and planetary radius. We also aim to determine whether planets that were previously engulfed in the envelope of their red giant host star can survive, even partially, as a planetary remnant. Methods. For this first paper, we performed injection-and-recovery tests of synthetic transits for a selection of representative Kepler, K2, and TESS light curves to determine which transiting bodies in terms of object radius and orbital period we will be able to detect with our tools. We also provide estimates for CHEOPS data, which we analyzed with the pycheops package. Results. Transiting objects with a radius ≤ 1.0 R⊕ can be detected in most of the Kepler, K2, and CHEOPS targets for the shortest orbital periods (1 d and shorter), reaching values as low as ∼0.3 R⊕ in the best cases. Sub-Earth-sized bodies are only reached for the brightest TESS targets and for those that were observed in a significant number of sectors. We also give a series of representative results for larger planets at greater distances, which strongly depend on the target magnitude and on the length and quality of the data. Conclusions. The TESS sample will provide the most important statistics for the global aim of measuring the planet occurrence rate around hot subdwarfs. The Kepler, K2, and CHEOPS data will allow us to search for planetary remnants, that is, very close and small (possibly disintegrating) objects.
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6.
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7.
  • Akiyama, Kazunori, et al. (författare)
  • First Sagittarius A* Event Horizon Telescope Results. VI. Testing the Black Hole Metric
  • 2022
  • Ingår i: Astrophysical Journal Letters. - : American Astronomical Society. - 2041-8213 .- 2041-8205. ; 930:2
  • Tidskriftsartikel (refereegranskat)abstract
    • Astrophysical black holes are expected to be described by the Kerr metric. This is the only stationary, vacuum, axisymmetric metric, without electromagnetic charge, that satisfies Einstein's equations and does not have pathologies outside of the event horizon. We present new constraints on potential deviations from the Kerr prediction based on 2017 EHT observations of Sagittarius A* (Sgr A*). We calibrate the relationship between the geometrically defined black hole shadow and the observed size of the ring-like images using a library that includes both Kerr and non-Kerr simulations. We use the exquisite prior constraints on the mass-to-distance ratio for Sgr A* to show that the observed image size is within similar to 10% of the Kerr predictions. We use these bounds to constrain metrics that are parametrically different from Kerr, as well as the charges of several known spacetimes. To consider alternatives to the presence of an event horizon, we explore the possibility that Sgr A* is a compact object with a surface that either absorbs and thermally reemits incident radiation or partially reflects it. Using the observed image size and the broadband spectrum of Sgr A*, we conclude that a thermal surface can be ruled out and a fully reflective one is unlikely. We compare our results to the broader landscape of gravitational tests. Together with the bounds found for stellar-mass black holes and the M87 black hole, our observations provide further support that the external spacetimes of all black holes are described by the Kerr metric, independent of their mass.
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8.
  • Laporte, N., et al. (författare)
  • ALMA Lensing Cluster Survey: A strongly lensed multiply imaged dusty system at z ≥ 6
  • 2021
  • Ingår i: Monthly Notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 505:4, s. 4838-4846
  • Tidskriftsartikel (refereegranskat)abstract
    • We report the discovery of an intrinsically faint, quintuply-imaged, dusty galaxy MACS0600-z6 at a redshift z = 6.07 viewed through the cluster MACSJ0600.1–2008 (z = 0.46). A ≃ 4σ dust detection is seen at 1.2mm as part of the ALMA Lensing Cluster Survey (ALCS), an on-going ALMA Large programme, and the redshift is secured via [C II] 158 μm emission described in a companion paper. In addition, spectroscopic follow-up with GMOS/Gemini-North shows a break in the galaxy’s spectrum, consistent with the Lyman break at that redshift. We use a detailed mass model of the cluster and infer a magnification μ ≳ 30 for the most magnified image of this galaxy, which provides an unprecedented opportunity to probe the physical properties of a sub-luminous galaxy at the end of cosmic reionization. Based on the spectral energy distribution, we infer lensing-corrected stellar and dust masses of 2.9-2.3+115 × 109 and 4.8-3.4+45 × 106 M☉, respectively, a star formation rate of 9.7-6.6+220 M☉ yr−1, an intrinsic size of 0.54-0.14+026 kpc, and a luminosity-weighted age of 200 ± 100 Myr. Strikingly, the dust production rate in this relatively young galaxy appears to be larger than that observed for equivalent, lower redshift sources. We discuss if this implies that early supernovae are more efficient dust producers and the consequences for using dust mass as a probe of earlier star formation.
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9.
  • Denes, H., et al. (författare)
  • Characterising the Apertif primary beam response
  • 2022
  • Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 667
  • Tidskriftsartikel (refereegranskat)abstract
    • Context. Phased array feeds (PAFs) are multi-element receivers in the focal plane of a telescope that make it possible to simultaneously form multiple beams on the sky by combining the complex gains of the individual antenna elements. Recently, the Westerbork Synthesis Radio Telescope (WSRT) was upgraded with PAF receivers to carry out several observing programs, including two imaging surveys and a time-domain survey. The Apertif imaging surveys use a configuration of 40 partially overlapping compound beams (CBs) simultaneously formed on the sky and arranged in an approximately rectangular shape. Aims. This work is aimed at characterising the response of the 40 Apertif CBs to create frequency-resolved I, XX, and YY polarization empirical beam shapes. The measured CB maps can be used for the image deconvolution, primary beam correction, and mosaicking processes of Apertif imaging data. Methods. We used drift scan measurements to measure the response of each of the 40 Apertif CBs. We derived beam maps for all individual beams in I, XX, and YY polarisation in 10 or 18 frequency bins over the same bandwidth as the Apertif imaging surveys. We sampled the main lobe of the beams and the side lobes up to a radius of 0.6 degrees from the beam centres. In addition, we derived beam maps for each individual WSRT dish. Results. We present the frequency and time dependence of the beam shapes and sizes. We compared the compound beam shapes derived with the drift scan method to beam shapes derived with an independent method using a Gaussian Process Regression comparison between the Apertif continuum images and the NRAO VLA Sky Survey (NVSS) catalogue. We find a good agreement between the beam shapes derived with the two independent methods.
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10.
  • Nikiel-Wroczynski, N., et al. (författare)
  • Exploring the properties of low-frequency radio emission and magnetic fields in a sample of compact galaxy groups using the LOFAR Two-Metre Sky Survey (LoTSS)
  • 2019
  • Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 622
  • Tidskriftsartikel (refereegranskat)abstract
    • We use the LOFAR Two-metre Sky Survey (LoTSS) Data Release I to identify the groups of galaxies (and individual galaxies) from the Hickson compact groups (HCG) and magnitude-limited compact groups (MLCG) samples that emit at the frequency of 150 MHz, characterise their radio emission (extended or limited to the galaxies), and compare new results to earlier observations and theoretical predictions. The detection of 73 systems (and 7 more - probably) out of 120, of which as many as 17 show the presence of extended radio structures, confirms the previous hypothesis of the common character of the magnetic field inside galaxy groups and its detectability. In order to investigate the future potential of low-frequency radio studies of galaxy groups, we also present a more detailed insight into four radio-emitting systems, for which the strength of the magnetic field inside their intergalactic medium (IGM) is calculated. The estimated values are comparable to that found inside star-forming galaxies, suggesting a dynamical and evolutionary importance of the magnetic field in galaxy groups.
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