| 1. |
- Johnson, Ann-Louise, et al.
(författare)
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Synthesis of barettin
- 2004
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Ingår i: Tetrahedron. - : Elsevier BV. - 0040-4020 .- 1464-5416. ; 60:4, s. 961-965
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Tidskriftsartikel (refereegranskat)abstract
- The indole alkaloid barettin (with bromine in 6-position), isolated from the marine sponge Geodia Barretti, has been synthesised via a Horner-Wadsworth-Emmons type reaction from 6-bromoindole-3-carboxaldehyde to introduce the dehydro-functionality. Subsequent deprotection and cyclisation afforded the natural product in Z-conformation.
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| 2. |
- Figueroa, Ricardo, et al.
(författare)
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A transmembrane inner nuclear membrane protein in the mitotic spindle
- 2010
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Ingår i: Nucleus (Austin). - 1949-1042. ; 1:3, s. 249-253
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Tidskriftsartikel (refereegranskat)abstract
- We have recently characterized a novel transmembrane protein of the inner nuclear membrane of mammalian cells. The protein has two very interesting features. First, despite being an integral membrane protein it is able to concentrate in the membranes colocalizing with the mitotic spindle in metaphase and anaphase. Hence, the protein was named Samp1, Spindle associated membrane protein 1. Secondly, it displays a functional connection to centrosomes. This article discusses various aspects of Samp1 in relation to possible cellular function(s).
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| 3. |
- Bergman, Jan, et al.
(författare)
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Studies of the reactions between indole-2,3-diones (isatins) and 2-aminobenzylamine
- 2003
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Ingår i: Tetrahedron. - 0040-4020 .- 1464-5416. ; 59:7, s. 1033-1048
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Tidskriftsartikel (refereegranskat)abstract
- Reflux of equimolecular amounts 2-aminobenzylamine and isatins in acetic acid produced indolo[3,2-c]quinolin-6-ones in good yields. A proposed mechanism involving initial formation of a spiro compound is given. This isolable intermediate subsequently rearranges via a sequential isocyanate ring opening and a cyclisation process to a urea derivative which finally cyclized to the indolo[3,2-c]quinolin-6-ones. The urea derivative could be prepared separately and cyclized selectively to indolo[3,2-c]quinolin-6-one. Reaction of N-acetylisatin with 2-aminobenzylamine at room temperature yielded the 1,4-benzodiazepinone 3-(2-acetamidophenyl)-1,5-dihydro-1,4-benzodiazepin-2one whereas its isomer 2(2-acetamidophenyl)-4,5-dihydro-1,4-benzodiazepin-3-one was obtained from 2-(2-acetylaminophenyl)-N-(2-aminobenzyl)-2-oxoacetamide in acetic acid at room temperature. The previously unknown linear isomer of indolo[3,2-c]quinolin-6-one, i.e. indolo[2,3-blquinolin-11-one, has been prepared by thermal (260degreesC) cyclization of methyl 2-phenylamino indole-3-carboxylate, which in turn was prepared in two steps from methyl indole-3-carboxyl ate. (C) 2003 Elsevier Science Ltd. All rights reserved.
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| 4. |
- Slätt, Johnny, 1976-, et al.
(författare)
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Oxygenation of 2,3-dihydroindoles.
- 2002
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Ingår i: Tetrahedron. - 0040-4020 .- 1464-5416. ; 58:45, s. 9187-9191
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Tidskriftsartikel (refereegranskat)abstract
- Indolines (2,3-dihydroindoles) and isatogens (3-oxo-3H-indole 1-oxides) have been prepd. in an efficient route starting from indoles substituted in position 2. Redn. of the 2-substituted indoles was performed with tin and hydrochloric acid to give racemic indolines, which were converted to isatogens by 3-chloroperoxybenzoic acid (m-CPBA). [on SciFinder(R)]
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| 5. |
- El-Beqqali, Aziza, 1966-, et al.
(författare)
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Determination of dopamine and serotonin in human urine samples utilizing microextraction online with liquid chromatography/electrospray tandem mas spectrometry
- 2007
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Ingår i: Journal of Separation Science. - : Wiley. - 1615-9306 .- 1615-9314. ; 30:3, s. 421-424
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Tidskriftsartikel (refereegranskat)abstract
- A specific LC-MS-MS method for the determination of dopamine and serotonin (5-hydroxytryptamine; 5HT) in human urine is described. The analytes were extracted from urine and preconcentrated by microextraction in a packed syringe (MEPS). The new method is very promising, very easy to use, fully automated, of low cost, and rapid in comparison to previously used methods. The method was validated and the standard curves were evaluated by means of quadratic regression and weighted by the inverse of the concentration: 1/x for the calibration range 50–4000 μg/L. The MEPS applied polymer (silica-C8) could be used more than 300 times. The extraction recovery was about 50%. The results showed close correlation coefficients (r2 A0.999) for all analytes in the calibration range studied. The accuracy of MEPS-LC-MS-MS was 100–101% for dopamine and 99–100% for 5HT. The interday precision (n = 3 days), expressed as the RSD%, was 6.0–7.7% for dopamine and 6.1–11% for 5HT. MEPS reduced the handling time by 12 times compared to a published method.
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| 6. |
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| 7. |
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| 8. |
- Bergman, Jan, et al.
(författare)
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Acid-induced dimerization of 3-(1H-indol-3-yl)maleimides. Formation of cyclopentindole derivatives
- 2000
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Ingår i: JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1. - : Royal Society of Chemistry (RSC). - 1470-4358 .- 1364-5463 .- 1472-7781. ; :16, s. 2615-2621
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Tidskriftsartikel (refereegranskat)abstract
- Acid-induced dimerizations of 3-substituted maleimides have been investigated, leading to e.g. the cyclopentindole 9 and the deeply coloured spiro compounds 24 and 25 in good yields. 3-(1H-Indol-3-yl)maleimide 6b readily gave the cycloaddition products 13-15 on treatment with appropriate dienophiles. In addition, several related 3,3-di-(1H-indol-3-yl)succinimides have been prepared and studied.
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| 9. |
- Bergman, Jan, et al.
(författare)
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Coupling reactions of indole-3-acetic acid derivatives. Synthesis of arcyriaflavin A
- 2000
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Ingår i: JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1. - : Royal Society of Chemistry (RSC). - 1470-4358 .- 1364-5463 .- 1472-7781. ; :16, s. 2609-2614
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Tidskriftsartikel (refereegranskat)abstract
- The bisindolesuccinic acid methyl ester 10 was obtained by an iodine-promoted coupling of the dianion 9. The diester was converted to the N-benzylimide 12, which was oxidatively cyclized to the indolo[2,3-a]pyrrolo[3,4-c]carbazole 15. The diester 10 could be directly transformed to the known indolocarbazole diester 27 via acid-induced intramolecular cyclization in TFA. The same methodology gave arcyriaflavin A 4 from the succinimide 18b.
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| 10. |
- Bergman, Jan, et al.
(författare)
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Reactions of 1,2-bis(1H-indol-2-yl)ethane : Formation of indolo[2,3-c]carbazole and cyclohept[1,2-b : 5,4-b ']bisindole derivatives
- 2000
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Ingår i: Tetrahedron. - 0040-4020 .- 1464-5416. ; 56:13, s. 1911-1916
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Tidskriftsartikel (refereegranskat)abstract
- 1,2-Bis(1H-indol-2-yl)ethane (9) has been prepared and converted into indolo[2,3-c]carbazole (8) using palladium acetate in refluxing acetic acid. Reaction of 9 with CoF3 in hot TFA led to isolation of cyclohept[1,2-b:5,4-b']bisindole derivatives 11 and 12, which could be elaborated into further derivatives. Treatment of 9 with orthoesters, aldehydes and ketones under acidic conditions afforded additional bisindoles containing a seven-membered ring.
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