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Spatially resolved ...
Spatially resolved clonal copy number alterations in benign and malignant tissue
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- Erickson, A (author)
- Univ Oxford, Nuffield Dept SurgicalSci, Oxford, England.
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- He, Mengxiao (author)
- KTH,Genteknologi,Science for Life Laboratory, SciLifeLab
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- Berglund, Emelie (author)
- KTH,Genteknologi,Science for Life Laboratory, SciLifeLab
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show more...
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- Marklund, Maja (author)
- KTH,Genteknologi,Science for Life Laboratory, SciLifeLab
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- Mirzazadeh, Reza (author)
- KTH,Science for Life Laboratory, SciLifeLab,Genteknologi
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- Schultz, N (author)
- Karolinska Institutet
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- Kvastad, Linda (author)
- KTH,Science for Life Laboratory, SciLifeLab,Genteknologi
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- Andersson, Alma (author)
- Karolinska Institutet,KTH,Genteknologi,Science for Life Laboratory, SciLifeLab
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- Bergenstråhle, Ludvig (author)
- KTH,Genteknologi,Science for Life Laboratory, SciLifeLab
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- Bergenstråhle, Joseph (author)
- KTH,Genteknologi,Science for Life Laboratory, SciLifeLab
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- Larsson, Ludvig (author)
- KTH,Genteknologi,Science for Life Laboratory, SciLifeLab
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- Galicia, Leire Alonso (author)
- KTH,Genteknologi,Science for Life Laboratory, SciLifeLab
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- Shamikh, A (author)
- Karolinska Institutet
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- Basmaci, E (author)
- Karolinska Institutet
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- De Stahl, TD (author)
- Karolinska Institutet
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Rajakumar, T (author)
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- Doultsinos, D (author)
- Univ Oxford, Nuffield Dept SurgicalSci, Oxford, England.;Oxford Univ Hosp NHS Fdn Trust, Dept Urol, Oxford, England.
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- Thrane, Kim (author)
- KTH,Genteknologi,Science for Life Laboratory, SciLifeLab
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Ji, AL (author)
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Khavari, PA (author)
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Tarish, F (author)
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Tanoglidi, A (author)
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- Maaskola, Jonas (author)
- KTH,Genteknologi,Science for Life Laboratory, SciLifeLab
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Colling, R (author)
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Mirtti, T (author)
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Hamdy, FC (author)
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Woodcock, DJ (author)
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- Helleday, T (author)
- Karolinska Institutet
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Mills, IG (author)
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Lamb, AD (author)
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- Lundeberg, Joakim (author)
- KTH,Science for Life Laboratory, SciLifeLab,Genteknologi
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Univ Oxford, Nuffield Dept SurgicalSci, Oxford, England Genteknologi (creator_code:org_t)
- 2022-08-10
- 2022
- English.
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In: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 608:7922, s. 360-
- Related links:
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Defining the transition from benign to malignant tissue is fundamental to improving early diagnosis of cancer1. Here we use a systematic approach to study spatial genome integrity in situ and describe previously unidentified clonal relationships. We used spatially resolved transcriptomics2 to infer spatial copy number variations in >120,000 regions across multiple organs, in benign and malignant tissues. We demonstrate that genome-wide copy number variation reveals distinct clonal patterns within tumours and in nearby benign tissue using an organ-wide approach focused on the prostate. Our results suggest a model for how genomic instability arises in histologically benign tissue that may represent early events in cancer evolution. We highlight the power of capturing the molecular and spatial continuums in a tissue context and challenge the rationale for treatment paradigms, including focal therapy.
Subject headings
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
- SAMHÄLLSVETENSKAP -- Ekonomi och näringsliv -- Företagsekonomi (hsv//swe)
- SOCIAL SCIENCES -- Economics and Business -- Business Administration (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Nature
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
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Erickson, A
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He, Mengxiao
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Berglund, Emelie
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Marklund, Maja
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Mirzazadeh, Reza
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Schultz, N
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show more...
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Kvastad, Linda
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Andersson, Alma
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Bergenstråhle, L ...
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Bergenstråhle, ...
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Larsson, Ludvig
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Galicia, Leire A ...
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Shamikh, A
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Basmaci, E
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De Stahl, TD
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Rajakumar, T
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Doultsinos, D
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Thrane, Kim
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Ji, AL
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Khavari, PA
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Tarish, F
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Tanoglidi, A
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Maaskola, Jonas
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Colling, R
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Mirtti, T
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Hamdy, FC
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Woodcock, DJ
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Helleday, T
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Mills, IG
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Lamb, AD
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Lundeberg, Joaki ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Genetics
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- SOCIAL SCIENCES
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SOCIAL SCIENCES
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and Economics and Bu ...
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and Business Adminis ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Nature
- By the university
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Karolinska Institutet
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Royal Institute of Technology