| 21. |
- Monti, M., et al.
(author)
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Metabolic Activity of Lymphoma Cells and Clinical Course in Non‐Hodgkin Lymphoma (NHL)
- 1981
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In: Scandinavian Journal of Haematology. - : Wiley. - 1600-0609 .- 0036-553X. ; 27:5, s. 305-310
-
Journal article (peer-reviewed)abstract
- By microcalorimetry the metabolic activity of malignant cells from 21 patients with non‐Hodgkin lymphoma was monitored. Heat production, a measure of the metabolic activity of cells, showed positive correlation with the clinical‐course of the disease. The heat produced by tumor cells from patients with progressive disease was 5.5 pW/cell, while that from patients responding to treatment was 3.1 pW/cell. The difference between the 2 groups is significant (P <0.05). A higher heat production was obtained in tumor cells from 7 out of 10 patients who were unresponsive to the therapy when compared with cells from 11 patients who had become asymptomatic as a result of the same therapy. Also heat production from blood lymphocytes was found to be higher (P <0.005) in the group of patients with progressive disease as compared to the group of patients who responded to therapy. The present results indicate an association between high heat production in lymphoma cells and blood lymphocytes and a poor prognosis. © Munksgaard 1981
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| 22. |
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| 23. |
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| 24. |
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| 25. |
- Olsson, Hakan, et al.
(author)
-
Hypophyseal tumor and gynecomastia preceding bilateral breast cancer development in a man
- 1984
-
In: Cancer. - 0008-543X. ; 53:9, s. 1974-1977
-
Journal article (peer-reviewed)abstract
- The case is reported of a 48‐year‐old man who, 26 years after treatment for a hypophyseal tumor and 11 years after the onset of bilateral gynecomastia, developed cancer of the left breast. Ten years after the first breast cancer operation a new cancer developed in his right breast. Hormonal investigation at the time of the second breast cancer operation revealed a low S‐FSH and a relative estrogen excess compared to testosterone. Values of thyroid and adrenal hormones were essentially normal, while P‐prolactin was elevated. Stimulatory tests of the hypophyseal function were in accordance with a partial hypophyseal insufficiency affecting the hypophyseal‐gonadal axis. Also, a weak elevation of S‐HGH was noted by an insulin tolerance test. Immunohistochemical analysis of the pituitary tumor 36 years later showed that the tumor could be classified as a prolactinoma. Cytogenetic analysis revealed a normal male chromosome karyotype.
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| 26. |
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| 27. |
- Olsson, H., et al.
(author)
-
Occupational exposure to organic solvents and Hogdkin's disease in man. A case-referent study
- 1980
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In: Scandinavian Journal of Work, Environment and Health. - : Scandinavian Journal of Work, Environment and Health. - 0355-3140 .- 1795-990X. ; 6:4, s. 302-305
-
Journal article (peer-reviewed)abstract
- A standardized personal interview schedule was used to study occupational exposure to organic solvents among 25 men aged 20-65 a with Hodgkin's disease and 50 referents matched for sex, age and residence. When exposure was defined as the handling of organic solvents every workday for at least 1 a within the 10-a period immediately preceding the interview, 12 of the Hodgkin's disease patients (48%) and six referents (12%) were occupationally exposed with a relative risk of 6.6 (p = 0.0005). For 9 of the 12 exposed Hodgkin's disease patients exposure to aromatic solvents was verified, and such exposure may well have occurred for the remaining three patients also. It was concluded that exposure to organic solvents may constitute an occupational risk with regard to Hodgkin's disease.
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| 28. |
- Olsson, H., et al.
(author)
-
Relation between age of mothers with breast cancer and sex of their children
- 1980
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In: British Medical Journal. - : BMJ. - 0959-8146. ; 281:6247, s. 1029-1031
-
Journal article (peer-reviewed)abstract
- In a consecutive series of 150 women with breast cancer 122 had borne one or more children. Sixty-two patients were aged below 55 years at diagnosis (group A) and 60 were 55 years or older (group B). In group A 91 out of 153 children (59%) were boys compared with 48 out of 141 (34%) in group B (p=0 000007). In group A 54 of the 62 patients (87%) had given birth to one or more boys compared with 35 of the 60 (58%) in group B (p=0 0003). The mean age at diagnosis in mothers of two or more boys was 49 0 years, in those of one boy 55-2 years, and in those of only girls 61 0 years. The differences between each of the mean ages was significant. The mean age at diagnosis in 28 nulliparous patients was 57-7 years. There was no significant correlation between the number of female pregnancies and age at diagnosis. These results suggest that in women liable to develop breast cancer male pregnancies are associated with an early onset of the disease. © 1980, British Medical Journal Publishing Group. All rights reserved.
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| 29. |
- Olsson, H., et al.
(author)
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Retrospective assessment of menstrual cycle length in patients with breast cancer, in patients with benign breast disease, and in women without breast disease
- 1983
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In: Journal of the National Cancer Institute. - : Oxford University Press (OUP). - 0027-8874 .- 1460-2105. ; 70:1, s. 17-20
-
Journal article (peer-reviewed)abstract
- The length of the menstrual cycle was compared in women with breast cancer, women with benign breast disease, and controls. Older women in general tended to report shorter menstrual cycles (P < 0.05). After correction for the age difference, breast cancer patients still reported a shorter average menstrual cycle length than benign breast disease patients and controls (P < 0.006). Very short cycles (≤21 days) were present in 20% of the breast cancer patients compared to 8% of the patients with benign breast disease and 4% of the controls (P < 0.0001). Long cycles (≥30 days) were not a feature of breast cancer patients (2%), whereas 20% of the patients with benign breast disease and 28% of the controls reported such long cycles (P < 0.0001). Irregular menstrual cycles were more common in benign breast disease patients (20%) than in cancer patients (10%) and controls (8%) (P < 0.001).
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| 30. |
- Olsson, Håkan, et al.
(author)
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Sex Ratio in Offspring of Patients with Non-Hodgkin Lymphoma
- 1982
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In: New England Journal of Medicine. - 0028-4793. ; 306:6, s. 367-368
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Journal article (peer-reviewed)abstract
- To the Editor: In a letter in the November 5 issue, Alperovitch and Feingold reported an increased sex ratio (male:female) among children of women with multiple sclerosis.1 We have observed a remarkably decreased sex ratio in the offspring of young adults with non-Hodgkin lymphoma. We recorded the sex of the children of 197 patients with this disease who were participating in an epidemiologic study and obtained the same information from a control group of 240 patients without any evident malignant disease. Interviewing the control patients established that they had mainly cardiovascular or respiratory disorders. The results of this study are. © 1982, Massachusetts Medical Society. All rights reserved.
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