| 1. |
- Ankerst, Jaro, et al.
(författare)
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Cross‐reacting tstas in adeno 7 and 12 tumors demonstrated by 51CR‐Cytotoxicity and isograft rejection tests
- 1969
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Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 4:3, s. 279-287
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Tidskriftsartikel (refereegranskat)abstract
- Antisera of mice hyperimmunized against syngeneic X‐irradiated adeno 12 tumor cells were tested for complement‐dependent cytotoxicity against an adeno 7 and an adeno 12 hamster tumor by a 51Cr‐cytotoxic test, developed to work on non‐lymphoid target cells. Significant isotope release above the level of release obtained after exposure to control sera was recorded with both tumors. There was no similar release from BHK‐C13 control hamster cells. The cytotoxic effect on hamster adeno 7 tumor cells was confirmed by the colony inhibition technique. Furthermore, it was demonstrated by transplantation tests in mice that the hamster adeno 7 tumor cells were immunogenic, causing an isograft immunity to adeno 12 tumors similar to that induced by adeno 12 hamster and mouse tumor cells.
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| 2. |
- Kato, Rei, et al.
(författare)
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Chromosome breakage induced in vivo by a carcinogenic hydrocarbon in bone marrow cells of the Chinese hamster
- 1969
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Ingår i: Hereditas. - : Springer Science and Business Media LLC. - 0018-0661 .- 1601-5223. ; 61:1-2, s. 1-8
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Tidskriftsartikel (refereegranskat)abstract
- THE morphology, incidence and distribution of chromosome breakage induced by 7,12-dimethylbenz (a) anthracene (DMBA) in a Chinese hamster cell line in vitro were studied recently by KATO (1968). The present work - a corresponding study of the immediate effects of DMBA on Chinese hamster cells in vivo - was undertaken as the first step in an investigation of the chromosomes of primary tumors induced by DMBA in the Chinese hamster.
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| 3. |
- Sjögren, Hans O., et al.
(författare)
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Effect of BCG and allogeneic tumour cells on adenovirus type 12 tumorigenesis in mice
- 1969
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 221:5183, s. 863-864
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Tidskriftsartikel (refereegranskat)abstract
- HAMSTERS and mice inoculated at birth with tumour viruses have been used in studies of the prophylactic effects of various treatments during the latent period. The incidence of primary tumours in hamsters infected at birth with SV40 is reduced if the virus is inoculated during the latent period1-3. Similar administration of adenovirus type 12 also inhibited the induction of tumours by SV404; this was taken as an indication of a cross-reaction between the tumour-specific transplantation antigens (TSTA) of SV40 and adeno 12 virus tumours. X-irradiated SV40 tumour cells which did not contain infectious virus were also effective in reducing the frequency of primary SV40 tumours when given at various times before tumour development2,5.
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