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Träfflista för sökning "AMNE:(MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper) srt2:(1985-1989)"

Sökning: AMNE:(MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper) > (1985-1989)

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  • Ekström, Per A R, et al. (författare)
  • Impaired nerve regeneration in streptozotocin-diabetic rats. Effects of treatment with an aldose reductase inhibitor
  • 1989
  • Ingår i: Journal of the Neurological Sciences. - 0022-510X. ; 93:2-3, s. 231-237
  • Forskningsöversikt (refereegranskat)abstract
    • Rats with streptozotocin-induced diabetes have a decreased rate of sciatic nerve regeneration. We studied the effects on this defect of treatment with the aldose reductase inhibitor, ponalrestat (25 mg/kg per day via an endogastric tube). The nerves of diabetic rats were crush-injured at 5 weeks of diabetes and regeneration evaluated 7 days later with the pinch-reflex test. Ponalrestat treatment was started at day 3 after streptozotocin injection and was continued for the whole experimental period, i.e. until 6 weeks of diabetes. The treatment prevented effectively the accumulation of sorbitol and fructose in the nerves of diabetic rats, but was without effect on the sciatic nerve regeneration (controls 21.8 ± 1.2 mm/7 days (mean ± SEM, n = 6), untreated diabetics 15.8 ± 1.8 (n = 7), ponalrestat-treated diabetics 16.2 ± 1.0 (n = 10)). The results indicate that there is no connection between increased sorbitol pathway flux and impaired regeneration in streptozotocin diabetic rats.
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  • Chung, Shin-Ho, et al. (författare)
  • Transition metal ions in epilepsy: an overview
  • 1986
  • Ingår i: Advances in Experimental Medicine and Biology. - 0065-2598. ; 203, s. 545-55
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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  • Hansson, H A, et al. (författare)
  • Evidence indicating trophic importance of IGF-I in regenerating peripheral nerves
  • 1986
  • Ingår i: Acta Physiologica Scandinavica. - : Wiley. - 0001-6772 .- 1365-201X. ; 126:4, s. 14-609
  • Tidskriftsartikel (refereegranskat)abstract
    • The mechanisms influencing regeneration of peripheral nerves are incompletely known, but growth factors are supposed to play a key role. In the present study, we demonstrate, with the aid of immunohistochemical methods, that somatomedin C (Sm-C/insulin-like growth factor I/IGF-I) rapidly increased from low to high concentrations, reaching peak values in 2 weeks, in regenerating sciatic nerves of adult rats. In addition, IGF-I was demonstrated extracellularly, never observed in the control nerves. Reactive Schwann cells appeared to be the major source for IGF-synthesis. Higher concentrations were seen in tubulated nerves as compared to sutured ones. It is proposed that IGF-I exerts important growth supporting effects on regenerating peripheral nerves.
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  • Lundborg, G, et al. (författare)
  • Intraneural edema following exposure to vibration
  • 1987
  • Ingår i: Scandinavian Journal of Work, Environment and Health. - 0355-3140. ; 13:4, s. 9-326
  • Tidskriftsartikel (refereegranskat)abstract
    • Peripheral neuropathy represents a well-known complication from long-term exposure to vibration. In the present study an experimental model is presented with the purpose of analyzing the formation of intraneural edema following vibration exposure. Vibration (82 Hz, peak-to-peak amplitude 0.21 mm) was induced in the hind limb of rats by the use of vibrating electric motors during 4 h/d for 5 d. Tracer techniques (with albumin Evans blue and horseradish peroxidase) were used to study the permeability of intraneural microvessels after the vibration exposure on day 5. It was found that the vibration trauma in this model induced epineurial edema in the sciatic nerve. It is hypothesized that the formation of intraneural edema may be an important pathophysiological factor in the occurrence of vibration-induced neuropathy.
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  • Gabrielsson, Britt, 1957, et al. (författare)
  • Effects of divalent metal ions on the uptake of glutamate and GABA from synaptosomal fractions
  • 1986
  • Ingår i: Brain Research. - 0006-8993 .- 1872-6240. ; 384:2, s. 218-23
  • Tidskriftsartikel (refereegranskat)abstract
    • The effects of divalent metal ions on high affinity uptake glutamate and GABA were examined, using crude and purified synaptosomal fractions prepared from brains of DBA/2CBI. The uptake velocities of both amino acids are severely reduced in the presence of Cu2+, Fe2+ and Zn2+ but remain unaffected by Co2+.
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  • Resultat 1-10 av 73

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