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Träfflista för sökning "FÖRF:(Helena Andersson) ;pers:(von Heijne Gunnar)"

Sökning: FÖRF:(Helena Andersson) > Von Heijne Gunnar

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1.
  • Lundin, Carolina, et al. (författare)
  • Membrane topology of the human seipin protein
  • 2006
  • Ingår i: FEBS Letters. - : Wiley. - 0014-5793 .- 1873-3468. ; 580:9, s. 2281-2284
  • Tidskriftsartikel (refereegranskat)abstract
    • The Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2) gene encodes an integral membrane protein, called seipin, of unknown function localized to the endoplasmic reticulum of eukaryotic cells. Seipin is associated with the heterogeneous genetic disease BSCL2, and mutations in an N-glycosylation motif links the protein to two other disorders, autosomal-dominant distal hereditary motor neuropathy type V and Silver syndrome. Here, we report a topological study of seipin using an in vitro topology mapping assay. Our results suggest that the predominant form of seipin is 462 residues long and has an N-cyt-C-cyt orientation with a long luminal loop between the two transmembrane helices.
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2.
  • Hessa, Tara, et al. (författare)
  • Recognition of transmembrane helices by the endoplasmic reticulum translocon
  • 2005
  • Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 433:7024, s. 377-381
  • Tidskriftsartikel (refereegranskat)abstract
    • Membrane proteins depend on complex translocation machineries for insertion into target membranes. Although it has long been known that an abundance of nonpolar residues in transmembrane helices is the principal criterion for membrane insertion, the specific sequence-coding for transmembrane helices has not been identified. By challenging the endoplasmic reticulum Sec61 translocon with an extensive set of designed polypeptide segments, we have determined the basic features of this code, including a 'biological' hydrophobicity scale. We find that membrane insertion depends strongly on the position of polar residues within transmembrane segments, adding a new dimension to the problem of predicting transmembrane helices from amino acid sequences. Our results indicate that direct protein - lipid interactions are critical during translocon-mediated membrane insertion.
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  • Resultat 1-3 av 3

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