| 1. |
- Sigurdardottir, Gunnthorunn, et al.
(författare)
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Cross-Cultural Validation of the RECAP of Atopic Eczema Question-naire in a Swedish Population
- 2024
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Ingår i: Acta Dermato-Venereologica. - : Medical Journals Sweden. - 0001-5555 .- 1651-2057. ; 104
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Tidskriftsartikel (refereegranskat)abstract
- A Swedish translation of the patient-reported outcome measure for assessing long-term control of atopic dermatitis, Recap of atopic eczema (RECAP), has not been validated. Cross-cultural translation and multi-centre validation of the translated RECAP questionnaire were therefore performed. Disease severity was assessed using the validated Investigator Global Assessment Scale for atopic dermatitis (vIGA-ADTM). The Swedish RECAP was completed by 208 individuals aged 16 years or older with a median age of 36 years (interquartile range [IQR] 27-48). The participants considered the questionnaire suitable for assessing eczema control. The median RECAP score (range 0-28) was 12 (IQR 5-19). The mean and median vIGA-ADTM scores (range 0-4) were 2 (standard deviation [SD] 2) and 3 (IQR 2-4), respectively. A correlation between RECAP and the vIGA-ADTM was observed (p < 0.001). There was no significant change in scores for participants who answered the questionnaire twice within 14 days. Over time, improved or worsened eczema, as evaluat-ed by vIGA-ADTM, affected RECAP scores significantly (p < 0.001). The study suggests that RECAP can assess AD control in a Swedish clinical setting and shows -acceptable reliability.
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| 2. |
- Alsterholm, Mikael, 1977, et al.
(författare)
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Establishment and utility of SwedAD : a nationwide Swedish registry for patients with atopic dermatitis receiving systemic pharmacotherapy
- 2023
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Ingår i: Acta Dermato-Venereologica. - : Medical Journals Sweden AB. - 0001-5555 .- 1651-2057. ; 103
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Tidskriftsartikel (refereegranskat)abstract
- SwedAD, a Swedish nationwide registry for patients with atopic dermatitis receiving systemic pharmacotherapy, was launched on 1 September 2019. We describe here the establishment of a user-friendly registry to the benefit of patients with atopic dermatitis. By 5 November 2022, 38 clinics had recorded 931 treatment episodes in 850 patients with an approximate national coverage rate of 40%. Characteristics at enrolment included median Eczema Area and Severity Index (EASI) 10.2 (interquartile range 4.0, 19.4), Patient-Oriented Eczema Measure (POEM) 18.0 (10.0, 24.0), Dermatology Life Quality Index (DLQI) 11.0 (5.0, 19.0) and Peak Itch Numerical Rating Scale-11 (NRS-11) 6.0 (3.0, 8.0). At 3 months, median EASI was 3.2 (1.0, 7.3) and POEM, DLQI, and NRS-11 were improved. Regional coverage varied, reflecting the distribution of dermatologists, the ratio of public to private healthcare, and difficulties in recruiting certain clinics. This study highlights the importance of a nationwide registry when managing systemic pharmacotherapy of atopic dermatitis.
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| 3. |
- Johansson, Emma
(författare)
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From genes to blooms : Diversity in microcystin phenotypes and mcy biosynthesis genes in the cyanobacterium Microcystis
- 2023. - 1
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Cyanobacterial blooms are increasing in occurrence and frequency world-wide, mainly due to eutrophication and increased water temperatures. In freshwater, Microcystis is one of the most common bloom-forming genera, renowned for producing the toxin microcystin which is harmful to humans and other mammals. The ability of Microcystis strains to produce microcystins is largely due to the presence or absence of genes encoding microcystin biosynthesis (i.e. the mcy gene cluster), and the toxicity of Microcystis blooms is therefore dependent on the presence of toxin producing genotypes in the population. Numerous laboratory studies and field studies have aimed at explaining what environmental factors drive toxic blooms, however, with various results. Moreover, there is limited understanding of what the eco-physiological role of microcystin might be, and what factors influence microcystin concentration in the water. The aims of this thesis were to examine 1) the phenotypic and genotypic composition and variation in Microcystis, with regards to microcystin-production, 2) the association between mcy genotypes and the observed microcystin phenotypes, and 3) what environmental conditions favour microcystin-producing Microcystis during blooms, and are associated to microcystin concentrations in lake systems.In paper I, Microcystis botrys strains were isolated and cultured from a single bloom, and their microcystin-profiles were analysed with mass spectrometry. I could show that the microcystin-producing M. botrys subpopulation contained multiple microcystin-phenotypes, and that the phenotypic diversity varied on a temporal scale. Not only were the proportions of microcystin-producing strains higher during early and late summer, but the microcystin-profiles were more diverse, and the number of microcystin variants produced by individual strains were higher. In paper II, I performed whole genome sequencing of the strains analysed in the first study. Thereby, I could characterise the variation within the mcy gene cluster, encoding for microcystin biosynthesis, and show how the composition of mcy genotypes relates to the observed phenotypes. One main finding was that both microcystin-producing and non-producing strains consist of several genotypes, that either possess the full mcy gene cluster, or partial operons. Based on the results of paper II, in paper III I developed a population-tailored marker for quantitative polymerase chain reaction (qPCR) targeting the mcyJ gene in the mcy gene cluster. I was thereby able to detect and quantify the abundance of toxigenic cells in natural populations of Microcystis spp., sampled from two Swedish lakes. I also sampled and analysed several environmental variables to determine which factors favour toxigenic vs non- toxigenic strains. The results confirmed the temporal succession of microcystin- producing and non-producing phenotypes observed in paper I. I could also show that toxigenic Microcystis spp. were associated with high concentrations of inorganic nitrogen, whereas microcystin concentrations were associated with soluble reactive phosphorus.To conclude, my results show that there is inherent phenotypic and genotypic variation in Microcystis: the studied subpopulations contain multiple microcystin- phenotypes, as well as mcy genotypes. The presence of several mcy genotypes, found in both microcystin-producing and non-producing phenotypes, indicate that microcystin production might not be attributed to the presence or absence of mcy genes alone. Furthermore, toxic Microcystis blooms are likely driven by nutrient availability in the studied systems, which confirms that management strategies for bloom mitigation should focus on both phosphorus and nitrogen reduction.
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| 4. |
- Johansson, Emma, et al.
(författare)
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Participatory future visions of collaborative agroecological farmer-pastoralist systems in Tanzania
- 2023
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Ingår i: Agroecology and Sustainable Food Systems. - : Informa UK Limited. - 2168-3565 .- 2168-3573. ; 47:4, s. 548-578
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Tidskriftsartikel (refereegranskat)abstract
- Agroecology is increasingly promoted as a way to create just and sustainable farm- and food systems. Although there are multiple initiatives to scale up agroecology, current socio-political structures often hinder its potential to transform food systems. This study uses participatory approaches to create paintings that envision agroecological futures in the context of increased farmer-pastoralist collaborations in Tanzania, how they would function, and what political action is needed to support such futures. The visions are based on focus group discussions with agroecological farmers and pastoralists, and a multi-stakeholder workshop with farmer and pastoralist representatives, innovative food system actors, and researchers. We find that the envisioned transformation of the food system would lead to positive effects on farmers’ and pastoralists’ income, autonomy, long-term planning, and producers’ and consumers’ health. We conclude that new policies and financial support systems are needed to enable the expansion of agroecological farming and food systems, by increasing the availability of organic markets, supporting domestic botanicals production, and by creating more inclusive and just food value chains.
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| 5. |
- Alsarve, Daniel, 1976-, et al.
(författare)
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A gang of ironworkers with the scent of blood : A participation observation of male dominance and its historical trajectories at Swedish semi-professional ice hockey events
- 2022
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Ingår i: International Review for the Sociology of Sport. - : Sage Publications. - 1012-6902 .- 1461-7218. ; 57:1, s. 54-72
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Tidskriftsartikel (refereegranskat)abstract
- Ice hockey has traditionally been a male-dominated culture that has both promoted and legitimised masculine dominance and gender inequality. The question is, how might ice hockey games, or other male-dominated sports, be organised differently and thus become more gender equal? Our ambition in this article is to initiate a discussion about how the construction of gender in ice hockey events operationalises or opposes the dominance of men and the marginalisation of women. The specific purpose is to identify techniques that configure men/masculinities as dominant in the ice hockey culture. Taking critical studies of men and masculinities as the point of departure, with a specific focus on the situational aspects of gender construction, this case study makes use of participatory observations of eight qualification games in Swedish semi-professional ice hockey. Our results show that men and certain types of masculinity dominate in the events framing the game and how this links the ice hockey players and the club with the local body-worker culture and its industrial, economic and historical context. Identification with these men is ideally created amongst male spectators, given that children and women do not have the same obvious place in the event’s narrative. Some clubs seek to include women and children in their matches, which affects both the atmosphere and the situation. By focusing on the events’ introductions and general narratives, and how they make use of a (masculine) version of the place’s past in the present, we discuss how the ice hockey culture contributes to the current hegemony of men and masculinities.
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| 6. |
- Gerhardt, Karin, et al.
(författare)
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Nog nu, politiker – ta klimatkrisen på allvar
- 2022
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Ingår i: Aftonbladet Debatt. - 1103-9000. ; -:-
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- 1944 svenska forskare och anställda i forskarvärlden: Vad är det ni inte förstår?
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| 7. |
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| 8. |
- Johansson, Emma K., et al.
(författare)
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Treatment Patterns among Patients with Atopic Dermatitis in Secondary Care : A National, Observational, Non-interventional, Retrospective Study in Sweden
- 2022
-
Ingår i: Acta Dermato-Venereologica. - : Medical Journals Sweden AB. - 0001-5555 .- 1651-2057. ; 102
-
Tidskriftsartikel (refereegranskat)abstract
- This non-interventional, observational, longitudinal study describes treatment patterns of atopic dermatitis (AD) in Sweden. Data from 3 Swedish registries were merged, and included patients who received an AD diagnosis (during the period 1997 to 2019) and had AD treatment prescribed (during the period 2006 to 2020). Treatment persistence, treatment sequen-cing, time-to-event analysis, and 12-month prevalence were analysed. Overall, data for 99,885 patients with AD were included, of whom 4,086 (4.1%) received systemic treatments. Median persistence rates were 12.6 (95% CI 11.9, 13.4) months for methotrexate, 10.8 (9.1, 13.0) months for azathioprine, 5.6 (3.8, 6.2) months for mycophenolate, 5.1 (4.4, 5.7) months for alitretinoin and 3.4 (3.2, 3.7) months for cyclosporine. Median (Q1, Q3) time from first secondary care visit for AD to first systemic treatment was 5.8 (2.2, 11.0) years overall and 4.4 (1.3, 9.1) years in the Stockholm region. Methotrexate was a prominent first-and second-line treatment used during the period 2006 to 2020. Dupilumab was introduced during the study period and was increasingly used as first-or second-line therapy over time. The 12-month prevalence of AD generally remained steady, with a gradual increase observed over time for the overall population. A steep increase was observed in Stockholm from 2011. This study shows that a small proportion of patients with AD are offered systemic treatments in Sweden, with long periods in secondary care prior to systemic treatments and low persistence on systemic treatments. Regional differences highlight a need for national treatment guidelines.
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| 9. |
- Johansson, Emma Li, et al.
(författare)
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Envisioning sustainable carbon sequestration in Swedish farmland
- 2022
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Ingår i: Environmental Science and Policy. - : Elsevier BV. - 1462-9011. ; 135, s. 16-25
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Tidskriftsartikel (refereegranskat)abstract
- Negative trends of climate change and biodiversity loss are closely linked with farming practices, and it is therefore essential to re-think how agricultural systems can sequester more carbon, and simultaneously create vital ecosystems. The overall aim of this research is to imagine Swedish farms as carbon sinks rather than sources, and how to re-design the current farm- and food system to also address other social, economic, and environmental sustainability challenges. This paper is the outcome of two visioning workshops together with participants in an ongoing initiative called Swedish Carbon Sequestration [Svensk Kolinlagring]. Participants discussed what alternative futures might look like, how they would function, and how to get there. The farm-level visions include perennial crops, keyline design, online farmers markets, increased collaboration between farms, and increased knowledge about soil health. The participants highlight complex interactions between animals, trees, leys, and crops that can support carbon sequestration. They also emphasize the need to increase both farmer's and society's knowledge about soil health and its multiple positive effects on carbon sequestration. In addition, a transformation of the farm- and food system would also contribute with positive effects on farmers income and their autonomy over decision making and long-term planning, in turn also improving farmers’ and consumers’ health. The participants highlight that the food system will be transformed by changes in consumer demand, increased knowledge and awareness, shortened value chains, and by changing policies and financial support systems to favor farmers who engage with agroecological principles of farming.
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| 10. |
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