SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "FÖRF:(Fredrik Westin) "

Sökning: FÖRF:(Fredrik Westin)

  • Resultat 1-10 av 123
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Zhou, Mi, et al. (författare)
  • Tensor-valued diffusion MRI of human acute stroke
  • 2024
  • Ingår i: Magnetic Resonance in Medicine. - 0740-3194. ; 91:5, s. 2126-2141
  • Tidskriftsartikel (refereegranskat)abstract
    • Purpose: Tensor-valued diffusion encoding can disentangle orientation dispersion and subvoxel anisotropy, potentially offering insight into microstructural changes after cerebral ischemia. The purpose was to evaluate tensor-valued diffusion MRI in human acute ischemic stroke, assess potential confounders from diffusion time dependencies, and compare to Monte Carlo diffusion simulations of axon beading. Methods: Linear (LTE) and spherical (STE) b-tensor encoding with inherently different effective diffusion times were acquired in 21 acute ischemic stroke patients between 3 and 57 h post-onset at 3 T in 2.5 min. In an additional 10 patients, STE with 2 LTE yielding different effective diffusion times were acquired for comparison. Diffusional variance decomposition (DIVIDE) was used to estimate microscopic anisotropy (μFA), as well as anisotropic, isotropic, and total diffusional variance (MKA, MKI, MKT). DIVIDE parameters, and diffusion tensor imaging (DTI)-derived mean diffusivity and fractional anisotropy (FA) were compared in lesion versus contralateral white matter. Monte Carlo diffusion simulations of various cylindrical geometries for all b-tensor protocols were used to interpret parameter measurements. Results: MD was ˜40% lower in lesions for all LTE/STE protocols. The DIVIDE parameters varied with effective diffusion time: higher μFA and MKA in lesion versus contralateral white matter for STE with longer effective diffusion time LTE, whereas the shorter effective diffusion time LTE protocol yielded lower μFA and MKA in lesions. Both protocols, regardless of diffusion time, were consistent with simulations of greater beading amplitude and intracellular volume fraction. Conclusion: DIVIDE parameters depend on diffusion time in acute stroke but consistently indicate neurite beading and larger intracellular volume fraction.
  •  
2.
  • Zhu, Ante, et al. (författare)
  • Human prostate MRI at ultrahigh-performance gradient : A feasibility study
  • 2024
  • Ingår i: Magnetic Resonance in Medicine. - 0740-3194. ; 91:2, s. 640-648
  • Tidskriftsartikel (refereegranskat)abstract
    • Purpose: To demonstrate the technical feasibility and the value of ultrahigh-performance gradient in imaging the prostate in a 3T MRI system. Methods: In this local institutional review board–approved study, prostate MRI was performed on 4 healthy men. Each subject was scanned in a prototype 3T MRI system with a 42-cm inner-diameter gradient coil that achieves a maximum gradient amplitude of 200 mT/m and slew rate of 500 T/m/s. PI-RADS V2.1–compliant axial T2-weighted anatomical imaging and single-shot echo planar DWI at standard gradient of 70 mT/m and 150 T/m/s were obtained, followed by DWI at maximum performance (i.e., 200 mT/m and 500 T/m/s). In comparison to state-of-the-art clinical whole-body MRI systems, the high slew rate improved echo spacing from 1020 to 596 μs and, together with a high gradient amplitude for diffusion encoding, TE was reduced from 55 to 36 ms. Results: In all 4 subjects (waist circumference = 81–91 cm, age = 45–65 years), no peripheral nerve stimulation sensation was reported during DWI. Reduced image distortion in the posterior peripheral zone prostate gland and higher signal intensity, such as in the surrounding muscle of high-gradient DWI, were noted. Conclusion: Human prostate MRI at simultaneously high gradient amplitude of 200 mT/m and slew rate of 500 T/m/s is feasible, demonstrating that improved gradient performance can address image distortion and T2 decay–induced SNR issues for in vivo prostate imaging.
  •  
3.
  • Chakwizira, Arthur, et al. (författare)
  • Diffusion MRI with free gradient waveforms on a high-performance gradient system : Probing restriction and exchange in the human brain
  • 2023
  • Ingår i: NeuroImage. - 1053-8119. ; 283
  • Tidskriftsartikel (refereegranskat)abstract
    • The dependence of the diffusion MRI signal on the diffusion time carries signatures of restricted diffusion and exchange. Here we seek to highlight these signatures in the human brain by performing experiments using free gradient waveforms designed to be selectively sensitive to the two effects. We examine six healthy volunteers using both strong and ultra-strong gradients (80, 200 and 300 mT/m). In an experiment featuring a large set of 150 gradient waveforms with different sensitivities to restricted diffusion and exchange, our results reveal unique and different time-dependence signatures in grey and white matter. Grey matter was characterised by both restricted diffusion and exchange and white matter predominantly by restricted diffusion. Exchange in grey matter was at least twice as fast as in white matter, across all subjects and all gradient strengths. The cerebellar cortex featured relatively short exchange times (115 ms). Furthermore, we show that gradient waveforms with tailored designs can be used to map exchange in the human brain. We also assessed the feasibility of clinical applications of the method used in this work and found that the exchange-related contrast obtained with a 25-minute protocol at 300 mT/m was preserved in a 4-minute protocol at 300 mT/m and a 10-minute protocol at 80 mT/m. Our work underlines the utility of free waveforms for detecting time dependence signatures due to restricted diffusion and exchange in vivo, which may potentially serve as a tool for studying diseased tissue.
  •  
4.
  • Chakwizira, Arthur, et al. (författare)
  • Diffusion MRI with pulsed and free gradient waveforms : effects of restricted diffusion and exchange
  • 2023
  • Ingår i: NMR in Biomedicine. - : Wiley. - 0952-3480 .- 1099-1492. ; 36:1
  • Tidskriftsartikel (refereegranskat)abstract
    • Monitoring time-dependence with diffusion MRI yields observables sensitive to compartment sizes (restricted diffusion) and membrane permeability (water exchange). However, restricted diffusion and exchange have opposite effects on the diffusion-weighted signal, which can lead to errors in parameter estimates. In this work, we propose a signal representation that incorporates the effects of both restricted diffusion and exchange up to second order in b-value and is compatible with gradient waveforms of arbitrary shape. The representation features mappings from a gradient waveform to two scalars that separately control the sensitivity to restriction and exchange. We demonstrate that these scalars span a two-dimensional space that can be used to choose waveforms that selectively probe restricted diffusion or exchange, eliminating the correlation between the two phenomena. We found that waveforms with specific but unconventional shapes provide an advantage over conventional pulsed and oscillating gradient acquisitions. We also show that parametrisation of waveforms into a two-dimensional space can be used to understand protocols from other approaches that probe restricted diffusion and exchange. For example, we found that the variation of mixing time in filter-exchange imaging corresponds to variation of our exchange-weighting scalar at a fixed value of the restriction-weighting scalar. The proposed signal representation was evaluated using Monte Carlo simulations in identical parallel cylinders with hexagonal and random packing as well as parallel cylinders with gamma-distributed radii. Results showed that the approach is sensitive to sizes in the interval 4 - 12 μm and exchange rates in the simulated range of 0 to 20 s -1 , but also that there is a sensitivity to the extracellular geometry. The presented theory constitutes a simple and intuitive description of how restricted diffusion and exchange influence the signal as well as a guide to protocol design capable of separating the two effects.
  •  
5.
  • Brabec, Jan, et al. (författare)
  • Histogram analysis of tensor-valued diffusion MRI in meningiomas : Relation to consistency, histological grade and type
  • 2022
  • Ingår i: NeuroImage: Clinical. - : Elsevier BV. - 2213-1582. ; 33
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: Preoperative radiological assessment of meningioma characteristics is of value for pre- and post-operative patient management, counselling, and surgical approach.PURPOSE: To investigate whether tensor-valued diffusion MRI can add to the preoperative prediction of meningioma consistency, grade and type.MATERIALS AND METHODS: 30 patients with intracranial meningiomas (22 WHO grade I, 8 WHO grade II) underwent MRI prior to surgery. Diffusion MRI was performed with linear and spherical b-tensors with b-values up to 2000 s/mm2. The data were used to estimate mean diffusivity (MD), fractional anisotropy (FA), mean kurtosis (MK) and its components-the anisotropic and isotropic kurtoses (MKA and MKI). Meningioma consistency was estimated for 16 patients during resection based on ultrasonic aspiration intensity, ease of resection with instrumentation or suction. Grade and type were determined by histopathological analysis. The relation between consistency, grade and type and dMRI parameters was analyzed inside the tumor ("whole-tumor") and within brain tissue in the immediate periphery outside the tumor ("rim") by histogram analysis.RESULTS: Lower 10th percentiles of MK and MKA in the whole-tumor were associated with firm consistency compared with pooled soft and variable consistency (n = 7 vs 9; U test, p = 0.02 for MKA 10 and p = 0.04 for MK10) and lower 10th percentile of MD with variable against soft and firm (n = 5 vs 11; U test, p = 0.02). Higher standard deviation of MKI in the rim was associated with lower grade (n = 22 vs 8; U test, p = 0.04) and in the MKI maps we observed elevated rim-like structure that could be associated with grade. Higher median MKA and lower median MKI distinguished psammomatous type from other pooled meningioma types (n = 5 vs 25; U test; p = 0.03 for MKA 50 and p = 0.03 and p = 0.04 for MKI 50).CONCLUSION: Parameters from tensor-valued dMRI can facilitate prediction of consistency, grade and type.
  •  
6.
  • Brabec, Jan, et al. (författare)
  • Separating Glioma Hyperintensities From White Matter by Diffusion-Weighted Imaging With Spherical Tensor Encoding
  • 2022
  • Ingår i: Frontiers in Neuroscience. - : Frontiers Media SA. - 1662-4548 .- 1662-453X. ; 16
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Tumor-related hyperintensities in high b-value diffusion-weighted imaging (DWI) are radiologically important in the workup of gliomas. However, the white matter may also appear as hyperintense, which may conflate interpretation.Purpose: To investigate whether DWI with spherical b-tensor encoding (STE) can be used to suppress white matter and enhance the conspicuity of glioma hyperintensities unrelated to white matter.Materials and Methods: Twenty-five patients with a glioma tumor and at least one pathology-related hyperintensity on DWI underwent conventional MRI at 3 T. The DWI was performed both with linear and spherical tensor encoding (LTE-DWI and STE-DWI). The LTE-DWI here refers to the DWI obtained with conventional diffusion encoding and averaged across diffusion-encoding directions. Retrospectively, the differences in contrast between LTE-DWI and STE-DWI, obtained at a b-value of 2,000 s/mm2, were evaluated by comparing hyperintensities and contralateral normal-appearing white matter (NAWM) both visually and quantitatively in terms of the signal intensity ratio (SIR) and contrast-to-noise ratio efficiency (CNReff).Results: The spherical tensor encoding DWI was more effective than LTE-DWI at suppressing signals from white matter and improved conspicuity of pathology-related hyperintensities. The median SIR improved in all cases and on average by 28%. The median (interquartile range) SIR was 1.9 (1.6 - 2.1) for STE and 1.4 (1.3 - 1.7) for LTE, with a significant difference of 0.4 (0.3 -0.5) (p < 10-4, paired U-test). In 40% of the patients, the SIR was above 2 for STE-DWI, but with LTE-DWI, the SIR was below 2 for all patients. The CNReff of STE-DWI was significantly higher than of LTE-DWI: 2.5 (2 - 3.5) vs. 2.3 (1.7 - 3.1), with a significant difference of 0.4 (-0.1 -0.6) (p < 10-3, paired U-test). The STE improved CNReff in 70% of the cases. We illustrate the benefits of STE-DWI in three patients, where STE-DWI may facilitate an improved radiological description of tumor-related hyperintensity, including one case that could have been missed out if only LTE-DWI was inspected.Conclusion: The contrast mechanism of high b-value STE-DWI results in a stronger suppression of white matter than conventional LTE-DWI, and may, therefore, be more sensitive and specific for assessment of glioma tumors and DWI-hyperintensities.
  •  
7.
  • Wårdell, Karin, et al. (författare)
  • Deep Brain Stimulation: Emerging Tools for Simulation, Data Analysis, and Visualization
  • 2022
  • Ingår i: Frontiers in Neuroscience. - : Frontiers Media S.A.. - 1662-4548 .- 1662-453X. ; 16
  • Forskningsöversikt (refereegranskat)abstract
    • Deep brain stimulation (DBS) is a well-established neurosurgical procedure for movement disorders that is also being explored for treatment-resistant psychiatric conditions. This review highlights important consideration for DBS simulation and data analysis. The literature on DBS has expanded considerably in recent years, and this article aims to identify important trends in the field. During DBS planning, surgery, and follow up sessions, several large data sets are created for each patient, and it becomes clear that any group analysis of such data is a big data analysis problem and has to be handled with care. The aim of this review is to provide an update and overview from a neuroengineering perspective of the current DBS techniques, technical aids, and emerging tools with the focus on patient-specific electric field (EF) simulations, group analysis, and visualization in the DBS domain. Examples are given from the state-of-the-art literature including our own research. This work reviews different analysis methods for EF simulations, tractography, deep brain anatomical templates, and group analysis. Our analysis highlights that group analysis in DBS is a complex multi-level problem and selected parameters will highly influence the result. DBS analysis can only provide clinically relevant information if the EF simulations, tractography results, and derived brain atlases are based on as much patient-specific data as possible. A trend in DBS research is creation of more advanced and intuitive visualization of the complex analysis results suitable for the clinical environment.
  •  
8.
  • Abramian, David, 1992-, et al. (författare)
  • Diffusion-Informed Spatial Smoothing of fMRI Data in White Matter Using Spectral Graph Filters
  • 2021
  • Ingår i: NeuroImage. - : Elsevier. - 1053-8119 .- 1095-9572. ; 237
  • Tidskriftsartikel (refereegranskat)abstract
    • Brain activation mapping using functional magnetic resonance imaging (fMRI) has been extensively studied in brain gray matter (GM), whereas in large disregarded for probing white matter (WM). This unbalanced treatment has been in part due to controversies in relation to the nature of the blood oxygenation level-dependent (BOLD) contrast in WM and its detachability. However, an accumulating body of studies has provided solid evidence of the functional significance of the BOLD signal in WM and has revealed that it exhibits anisotropic spatio-temporal correlations and structure-specific fluctuations concomitant with those of the cortical BOLD signal. In this work, we present an anisotropic spatial filtering scheme for smoothing fMRI data in WM that accounts for known spatial constraints on the BOLD signal in WM. In particular, the spatial correlation structure of the BOLD signal in WM is highly anisotropic and closely linked to local axonal structure in terms of shape and orientation, suggesting that isotropic Gaussian filters conventionally used for smoothing fMRI data are inadequate for denoising the BOLD signal in WM. The fundamental element in the proposed method is a graph-based description of WM that encodes the underlying anisotropy observed across WM, derived from diffusion-weighted MRI data. Based on this representation, and leveraging graph signal processing principles, we design subject-specific spatial filters that adapt to a subject’s unique WM structure at each position in the WM that they are applied at. We use the proposed filters to spatially smooth fMRI data in WM, as an alternative to the conventional practice of using isotropic Gaussian filters. We test the proposed filtering approach on two sets of simulated phantoms, showcasing its greater sensitivity and specificity for the detection of slender anisotropic activations, compared to that achieved with isotropic Gaussian filters. We also present WM activation mapping results on the Human Connectome Project’s 100-unrelated subject dataset, across seven functional tasks, showing that the proposed method enables the detection of streamline-like activations within axonal bundles.
  •  
9.
  • Behjat, Hamid, et al. (författare)
  • Characterization of Spatial Dynamics of Fmri Data in White Matter Using Diffusion-Informed White Matter Harmonics
  • 2021
  • Ingår i: 2021 IEEE 18th International Symposium On Biomedical Imaging (ISBI). - : Institute of Electrical and Electronics Engineers (IEEE). - 1945-8452 .- 1945-7928. - 9781665412469 - 9781665429474
  • Konferensbidrag (refereegranskat)abstract
    • In this work, we leverage the Laplacian eigenbasis of voxelwise white matter (WM) graphs derived from diffusionweighted MRI data, dubbed WM harmonics, to characterize the spatial structure of WM fMRI data. Our motivation for such a characterization is based on studies that show WM fMRI data exhibit a spatial correlational anisotropy that coincides with underlying fiber patterns. By quantifying the energy content of WM fMRI data associated with subsets of WM harmonics across multiple spectral bands, we show that the data exhibits notable subtle spatial modulations under functional load that are not manifested during rest. WM harmonics provide a novel means to study the spatial dynamics of WM fMRI data, in such way that the analysis is informed by the underlying anatomical structure.
  •  
10.
  • de Almeida Martins, João P., et al. (författare)
  • Neural networks for parameter estimation in microstructural MRI : Application to a diffusion-relaxation model of white matter
  • 2021
  • Ingår i: NeuroImage. - : Elsevier BV. - 1053-8119. ; 244
  • Tidskriftsartikel (refereegranskat)abstract
    • Specific features of white matter microstructure can be investigated by using biophysical models to interpret relaxation-diffusion MRI brain data. Although more intricate models have the potential to reveal more details of the tissue, they also incur time-consuming parameter estimation that may converge to inaccurate solutions due to a prevalence of local minima in a degenerate fitting landscape. Machine-learning fitting algorithms have been proposed to accelerate the parameter estimation and increase the robustness of the attained estimates. So far, learning-based fitting approaches have been restricted to microstructural models with a reduced number of independent model parameters where dense sets of training data are easy to generate. Moreover, the degree to which machine learning can alleviate the degeneracy problem is poorly understood. For conventional least-squares solvers, it has been shown that degeneracy can be avoided by acquisition with optimized relaxation-diffusion-correlation protocols that include tensor-valued diffusion encoding. Whether machine-learning techniques can offset these acquisition requirements remains to be tested. In this work, we employ artificial neural networks to vastly accelerate the parameter estimation for a recently introduced relaxation-diffusion model of white matter microstructure. We also develop strategies for assessing the accuracy and sensitivity of function fitting networks and use those strategies to explore the impact of the acquisition protocol. The developed learning-based fitting pipelines were tested on relaxation-diffusion data acquired with optimal and sub-optimal acquisition protocols. Networks trained with an optimized protocol were observed to provide accurate parameter estimates within short computational times. Comparing neural networks and least-squares solvers, we found the performance of the former to be less affected by sub-optimal protocols; however, model fitting networks were still susceptible to degeneracy issues and their use could not fully replace a careful design of the acquisition protocol.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 123
Typ av publikation
konferensbidrag (44)
tidskriftsartikel (42)
bokkapitel (17)
rapport (9)
forskningsöversikt (4)
doktorsavhandling (3)
visa fler...
licentiatavhandling (3)
annan publikation (1)
visa färre...
Typ av innehåll
refereegranskat (91)
övrigt vetenskapligt/konstnärligt (31)
populärvet., debatt m.m. (1)
Författare/redaktör
Westin, Carl-Fredrik (104)
Knutsson, Hans (47)
Szczepankiewicz, Fil ... (26)
Nilsson, Markus (25)
Knutsson, Hans, 1950 ... (15)
Brun, Anders, 1976- (12)
visa fler...
Topgaard, Daniel (10)
Herberthson, Magnus, ... (9)
Westin, Carl-Fredrik ... (8)
Ångström, Hans-Erik (7)
Özarslan, Evren (6)
van Westen, Danielle (6)
Herberthson, Magnus (6)
Sundgren, Pia C. (5)
Lasič, Samo (5)
Englund, Elisabet (4)
Knutsson, Linda (4)
Pasternak, Ofer (4)
Wårdell, Karin, 1959 ... (4)
Lampinen, Björn (4)
Yolcu, Cem (4)
Brabec, Jan (4)
Özarslan, Evren, 197 ... (3)
Zsigmond, Peter (3)
Kikinis, Ron (3)
Granlund, Gösta (3)
de Almeida Martins, ... (3)
Abramian, David, 199 ... (2)
Eklund, Anders, 1981 ... (2)
Aganj, Iman (2)
Behjat, Hamid (2)
Wiklund, Johan (2)
Andersson, Mats (2)
Palombo, Marco (2)
Hansson, Oskar (2)
Fuchs, Laszlo (2)
Ståhlberg, Freddy (2)
Maier, Stephan E (2)
Zsigmond, Peter, 196 ... (2)
Granlund, Gösta H. (2)
Mårtensson, Johan (2)
Forsberg, Daniel (2)
Park, Hae-Jeong (2)
Svensson, Björn, 197 ... (2)
Wrangsjö, Andreas, 1 ... (2)
Bryskhe, Karin (2)
Chakwizira, Arthur (2)
Zhu, Ante (2)
Wiklund, Johan, 1959 ... (2)
Westin, Fredrik, 197 ... (2)
visa färre...
Lärosäte
Linköpings universitet (87)
Lunds universitet (32)
Kungliga Tekniska Högskolan (10)
Umeå universitet (1)
Uppsala universitet (1)
Stockholms universitet (1)
visa fler...
Karolinska Institutet (1)
visa färre...
Språk
Engelska (123)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (38)
Teknik (31)
Naturvetenskap (17)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy