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- Alpenberg, Jan, Docent, 1964-, et al.
(författare)
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Capital investments in the Swedish forest industry
- 2022
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Ingår i: Presented at the 17th Asia-Pacific Management Accounting Association Annual Conference (APMAA 2022), Bangkok, Thailand, November 9-11, 2022. - : Asia-Pacific Management Accounting Association.
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Konferensbidrag (refereegranskat)abstract
- The purpose of this research is to gain understanding of how companies in the Swedish forest industry proceed in capital investment assessments regarding tangible investments. The research was conducted through a determination of which financial methods are used and which non-financial considerations (strategic, environmental, and social) are taken into account while assessing tangible investments. In order to enable a research of investment assessment in the Swedish forest industry, 10 companies have been studied with the use of qualitative (based on the interviews) method. The majority of the investment appraisal methods used in the Swedish forest companies have been observed in previous research, both domestically and internationally. The fact that the payback method is the most widely used method in the Swedish forest industry is in direct contrast to the application in the American forest industry, where discounted cash flows methods are most common. Net present value, internal rate of return, and sensitivity analysis are also used but not in all examined companies and not for all investments. Another distinctive finding is that the forest companies are happy to combine different calculation methods to increase the probability of succeeding in mapping a true picture of future investment financial consequences. The results of the study show that the investment assessment in the forest industry has several industry-specific features, which is expressed in the form of strategy, environmental, safety promotion becoming extra important for the forest companies, which stands out in relation to previous research.
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- Zetterblad, Jenny, et al.
(författare)
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Genomics based analysis of interactions between developing B-lymphocytes and stromal cells reveal complex interactions and two-way communication
- 2010
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Ingår i: BMC Genomics. - : Springer Science and Business Media LLC. - 1471-2164. ; 11:108
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Tidskriftsartikel (refereegranskat)abstract
- Background: The use of functional genomics has largely increased our understanding of cell biology and promises to help the development of systems biology needed to understand the complex order of events that regulates cellular differentiation in vivo. One model system clearly dependent on the integration of extra and intra cellular signals is the development of B-lymphocytes from hematopoietic stem cells in the bone marrow. This developmental pathway involves several defined differentiation stages associated with specific expression of genes including surface markers that can be used for the prospective isolation of the progenitor cells directly from the bone marrow to allow for ex vivo gene expression analysis. The developmental process can be simulated in vitro making it possible to dissect information about cell/cell communication as well as to address the relevance of communication pathways in a rather direct manner. Thus we believe that B-lymphocyte development represents a useful model system to take the first steps towards systems biology investigations in the bone marrow. Results: In order to identify extra cellular signals that promote B lymphocyte development we created a database with approximately 400 receptor ligand pairs and software matching gene expression data from two cell populations to obtain information about possible communication pathways. Using this database and gene expression data from NIH3T3 cells (unable to support B cell development), OP-9 cells (strongly supportive of B cell development), pro-B and pre-B cells as well as mature peripheral B-lineage cells, we were able to identify a set of potential stage and stromal cell restricted communication pathways. Functional analysis of some of these potential ways of communication allowed us to identify BMP-4 as a potent stimulator of B-cell development in vitro. Further, the analysis suggested that there existed possibilities for progenitor B cells to send signals to the stroma. The functional consequences of this were investigated by co-culture experiments revealing that the co-incubation of stromal cells with B cell progenitors altered both the morphology and the gene expression pattern in the stromal cells. Conclusions: We believe that this gene expression data analysis method allows for the identification of functionally relevant interactions and therefore could be applied to other data sets to unravel novel communication pathways.
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- Hansson, Frida, et al.
(författare)
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Exit of pediatric pre-B acute lymphoblastic leukaemia cells from the bone marrow to the peripheral blood is not associated with cell maturation or alterations in gene expression
- 2008
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Ingår i: Molecular Cancer. - : Springer Science and Business Media LLC. - 1476-4598. ; 7
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Tidskriftsartikel (refereegranskat)abstract
- Background: Childhood pre-B acute lymphoblastic leukemia (ALL) is a bone marrow (BM) derived disease, which often disseminates out of the BM cavity, where malignant cells to a variable degree can be found circulating in the peripheral blood (PB). Normal pre-B cells are absolutely dependent on BM stroma for survival and differentiation. It is not known whether transformed pre-B ALL cells retain any of this dependence, which possibly could impact on drug sensitivity or MRD measurements. Results: Pre-B ALL cells, highly purified by a novel method using surface expression of CD19 and immunoglobulin light chains, from BM and PB show a very high degree of similarity in gene expression patterns, with differential expression of vascular endothelial growth factor (VEGF) as a notable exception. In addition, the cell sorting procedure revealed that in 2 out of five investigated patients, a significant fraction of the malignant cells had matured beyond the pre-B cell stage. Conclusion: The transition of ALL cells from the BM into the circulation does not demand, or result in, major changes of gene expression pattern. This might indicate an independence of BM stroma on the part of transformed pre-B cells, which contrasts with that of their normal counterparts. © 2008 Hansson et al, licensee BioMed Central Ltd.
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