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- Hilgendorf, Martin, 1999, et al.
(författare)
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FORTE: an extensible framework for robustness and efficiency in data transfer pipelines
- 2023
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Ingår i: DEBS 2023 - Proceedings of the 17th ACM International Conference on Distributed and Event-based Systems. ; , s. 139-150
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Konferensbidrag (refereegranskat)abstract
- In the age of big data and growing product complexity, it is common to monitor many aspects of a product or system, in order to extract well-founded intelligence and draw conclusions, to continue driving innovation. Automating and scaling processes in data-pipelines becomes essential to keep pace with increasing rates of data generated by such practices, while meeting security, governance, scalability and resource-efficiency demands.We present FORTE, an extensible framework for robustness and transfer-efficiency in data pipelines. We identify sources of potential bottlenecks and explore the design space of approaches to deal with the challenges they pose. We study and evaluate synergetic effects of data compression and in-memory processing as well as task scheduling, in association with pipeline performance.A prototype implementation of FORTE is implemented and studied in a use-case at Volvo Trucks for high-volume production-level data sets, in the order of magnitude of hundreds of gigabytes to terabytes per burst. Various general-purpose lossless data compression algorithms are evaluated, in order to balance compression effectiveness and time in the pipeline.All in all, FORTE enables to deal with trade-offs and achieve benefits in latency and sustainable rate (up to 1.8 times better), effectiveness in resource utilisation, all while also enabling additional features such as integrity verification, logging, monitoring and traceability, as well as cataloguing of transferred data. We also note that the resource efficiency improvements achievable with FORTE, and its extensibility, can imply further benefits regarding scheduling, orchestration and energy-efficiency in such pipelines.
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| 2. |
- Nordanstig, Joakim, et al.
(författare)
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Mortality with Paclitaxel-Coated Devices in Peripheral Artery Disease.
- 2020
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Ingår i: The New England journal of medicine. - : Massachusetts Medical Society. - 1533-4406 .- 0028-4793. ; 383, s. 2538-46
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Tidskriftsartikel (refereegranskat)abstract
- The results of a recent meta-analysis aroused concern about an increased risk of death associated with the use of paclitaxel-coated angioplasty balloons and stents in lower-limb endovascular interventions for symptomatic peripheral artery disease.We conducted an unplanned interim analysis of data from a multicenter, randomized, open-label, registry-based clinical trial. At the time of the analysis, 2289 patients had been randomly assigned to treatment with drug-coated devices (the drug-coated-device group, 1149 patients) or treatment with uncoated devices (the uncoated-device group, 1140 patients). Randomization was stratified according to disease severity on the basis of whether patients had chronic limb-threatening ischemia (1480 patients) or intermittent claudication (809 patients). The single end point for this interim analysis was all-cause mortality.No patients were lost to follow-up. Paclitaxel was used as the coating agent for all the drug-coated devices. During a mean follow-up of 2.49 years, 574 patients died, including 293 patients (25.5%) in the drug-coated-device group and 281 patients (24.6%) in the uncoated-device group (hazard ratio, 1.06; 95% confidence interval, 0.92 to 1.22). At 1 year, all-cause mortality was 10.2% (117 patients) in the drug-coated-device group and 9.9% (113 patients) in the uncoated-device group. During the entire follow-up period, there was no significant difference in the incidence of death between the treatment groups among patients with chronic limb-threatening ischemia (33.4% [249 patients] in the drug-coated-device group and 33.1% [243 patients] in the uncoated-device group) or among those with intermittent claudication (10.9% [44 patients] and 9.4% [38 patients], respectively).In this randomized trial in which patients with peripheral artery disease received treatment with paclitaxel-coated or uncoated endovascular devices, the results of an unplanned interim analysis of all-cause mortality did not show a difference between the groups in the incidence of death during 1 to 4 years of follow-up. (Funded by the Swedish Research Council and others; ClinicalTrials.gov number, NCT02051088.).
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| 3. |
- Liljeqvist, Moritz Lindquist, et al.
(författare)
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Neutrophil Elastase-Derived Fibrin Degradation Products Indicate Presence of Abdominal Aortic Aneurysms and Correlate with Intraluminal Thrombus Volume
- 2018
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Ingår i: Thrombosis and Haemostasis. - : Schattauer GmbH Verlag für Medizin und Naturwissenschaften. - 0340-6245 .- 2567-689X. ; 118:2, s. 329-339
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Tidskriftsartikel (refereegranskat)abstract
- Background The intraluminal thrombi (ILT) of abdominal aortic aneurysms (AAA) contain neutrophils, which can secrete elastase. We evaluated whether plasma neutrophil elastase-derived cross-linked fibrin degradation products (E-XDP) could reveal the presence, size and mechanical stress of AAAs and its ILTs. Methods E-XDP and D-dimer were measured in plasma from 37 male patients with AAA and 42 male controls. The ILT volumes of the AAAs and any coexisting aneurysms could be measured in 29 patients and finite element analysis was performed to estimate mechanical stress of the ILT. E-XDP, neutrophil elastase and neutrophil marker CD66acd were evaluated in aortic tissue with immunohistochemistry (IHC). The association between ILT volume and E-XDP was validated in a separate cohort (n = 51). Results E-XDP levels were elevated in patients with AAA compared with controls (p = 5.8e-13), indicated AAA with 98% sensitivity, 86% specificity and increased with presence of coexisting aneurysms. The association between AAA and increased E-XDP was independent of smoking, comorbidities and medication. E-XDP correlated with volume of all ILTs (r = 0.76, p = 4.5e-06), mean ILTstress (r = 0.46, p = 0.013) and the volume of the AAA-associated ILT (r = 0.64, p = 0.00017). E-XDP correlated stronger with ILT volume compared with D-dimer (r = 0.76 vs. r = 0.64, p = 0.018). The correlation between E-XDP and ILT volume was validated in the separate cohort (r = 0.53, p = 7.6e-05). IHC revealed E-XDP expression in the ILT, spatially related to neutrophil elastase and neutrophils. Conclusion E-XDP is a marker of the presence of AAA and coexisting aneurysms as well as the volume and mechanical stress of the ILT.
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| 4. |
- Blomgren, Lena, 1957-, et al.
(författare)
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A comparison of magnetic resonance venography findings and venous occlusion plethysmography variables in postthrombotic syndrome
- 2017
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Ingår i: Vascular. - : Royal Society of Medicine Press. - 1708-5381 .- 1708-539X. ; 25:4, s. 406-411
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Tidskriftsartikel (refereegranskat)abstract
- Objective: The relation between venous morphology and venous function in postthrombotic syndrome is poorly understood. The aim of this study was to compare obstruction and collateralization as seen with magnetic resonance venography with variables of venous occlusion plethysmography in patients with postthrombotic syndrome.Methods: Medical records, magnetic resonance venography and venous occlusion plethysmography data were analyzed in 28 patients (33 legs). Magnetic resonance venography images were scored for degree of obstruction and collateralization in segments of pelvic and abdominal veins and correlated to venous occlusion plethysmography data.Results: Obstruction of the inferior vena cava correlated with an overall increase of collaterals ( p < 0.001). The summary scores of collaterals or obstructions did not correlate with venous occlusion plethysmography variables. Relative expelled volume at 4 s correlated inversely with obstruction of the inferior vena cava ( p = 0.045) and vertebral collateralization ( p = 0.033).Conclusions: Modest correlations were found between magnetic resonance venography scores and venous occlusion plethysmography variables. Prospective studies with refined scoring and magnetic resonance venography techniques may increase our knowledge further.
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