| 1. |
- Karlsson Blom, Lisa, 1982-, et al.
(författare)
-
Antirasismens rör(l)ighet
- 2024
-
Ingår i: Antirasismer och antirasister. - Stockholm : Bokförlaget atlas & Kriterium. - 9789174450606 - 9789174451092 ; , s. 38-63
-
Bokkapitel (refereegranskat)
|
|
| 2. |
|
|
| 3. |
- Backer, Vibeke, et al.
(författare)
-
Clinical characteristics of the BREATHE cohort–a real-life study on patients with asthma and COPD
- 2020
-
Ingår i: European clinical respiratory journal. - : Informa UK Limited. - 2001-8525. ; 7:1
-
Tidskriftsartikel (refereegranskat)abstract
- Background: The BREATHE study is a cross-sectional study of real-life patients with asthma and/or COPD in Denmark and Sweden aiming to increase the knowledge across severities and combinations of obstructive airway disease. Design: Patients with suspicion of asthma and/or COPD and healthy controls were invited to participate in the study and had a standard evaluation performed consisting of questionnaires, physical examination, FeNO and lung function, mannitol provocation test, allergy test, and collection of sputum and blood samples. A subgroup of patients and healthy controls had a bronchoscopy performed with a collection of airway samples. Results: The study population consisted of 1403 patients with obstructive airway disease (859 with asthma, 271 with COPD, 126 with concurrent asthma and COPD, 147 with other), and 89 healthy controls (smokers and non-smokers). Of patients with asthma, 54% had moderate-to-severe disease and 46% had mild disease. In patients with COPD, 82% had groups A and B, whereas 18% had groups C and D classified disease. Patients with asthma more frequently had childhood asthma, atopic dermatitis, and allergic rhinitis, compared to patients with COPD, asthma + COPD and Other, whereas FeNO levels were higher in patients with asthma and asthma + COPD compared to COPD and Other (18 ppb and 16 ppb vs 12.5 ppb and 14 ppb, p < 0.001). Patients with asthma, asthma + COPD and Other had higher sputum eosinophilia (1.5%, 1.5%, 1.2% vs 0.75%, respectively, p < 0.001) but lower sputum neutrophilia (39.3, 43.5%, 40.8% vs 66.8%, p < 0.001) compared to patients with COPD. Conclusions: The BREATHE study provides a unique database and biobank with clinical information and samples from 1403 real-life patients with asthma, COPD, and overlap representing different severities of the diseases. This research platform is highly relevant for disease phenotype- and biomarker studies aiming to describe a broad spectrum of obstructive airway diseases.
|
|
| 4. |
|
|
| 5. |
- Wigén, Jenny Cecilia, et al.
(författare)
-
Glycosaminoglycans: a link between development and regeneration in the lung : a link between development and regeneration in the lung
- 2019
-
Ingår i: Stem Cells and Development. - : Mary Ann Liebert Inc. - 1557-8534 .- 1547-3287. ; 28:13, s. 823-832
-
Tidskriftsartikel (refereegranskat)abstract
- What can we learn from embryogenesis to increase our understanding of how regeneration of damaged adult lung tissue could be induced in serious lung diseases such as chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and asthma? The local tissue niche determines events in both embryogenesis and repair of the adult lung. Important constituents of the niche are extracellular matrix (ECM) molecules including proteoglycans and glycosaminoglycans (GAG). GAGs, strategically located in the pericellular and extracellular space, bind developmentally active growth factors and morphogenes such as fibroblast growth factors (FGF), transforming growth factor- (TGF-) and bone morphogenetic proteins (BMPs) aside from cytokines. These interactions affect activities in many cells, including stem cells, important in development and tissue regeneration. Moreover, it is becoming clear that the "inherent code", such as sulfation of disaccharides of GAGs is a strong determinant of cellular outcome. Sulfation pattern, deacetylations and epimerizations of GAG chains function as tuning forks in gradient formation of morphogens, growth factors and cytokines. Learning to tune these fine instruments, i.e. interactions between growth factors (GF), chemokines and cytokines with the specific disaccharide code of GAGs in the adult lung, could become the key to unlock inherent regenerative forces to override pathological remodeling. This review aims to give an overview of the role GAGs play during development and similar events in regenerative efforts in the adult lung.
|
|
| 6. |
- Blom, Lisa Karlsson, 1982, et al.
(författare)
-
Tiggarnas liv fyllt av övergrepp
- 2014
-
Ingår i: Göteborgs-Posten. - 1103-9345. ; :19 mars
-
Tidskriftsartikel (populärvet., debatt m.m.)
|
|
| 7. |
- Junker, Johan, et al.
(författare)
-
Differentiation of human dermal fibroblasts towards endothelial cells
- 2013
-
Ingår i: Differentiation. - Oxon, United Kingdom : Elsevier. - 0301-4681 .- 1432-0436. ; 85:3, s. 67-77
-
Tidskriftsartikel (refereegranskat)abstract
- The ultimate goal of vascular tissue engineering is the production of functional grafts for clinical use. Difficulties acquiring autologous endothelial cells have motivated the search for alternative cell sources. Differentiation of dermal fibroblasts towards several mesenchymal lineages as well as endothelial cells has been proposed. The aim of the present study was to investigate the endothelial differentiation capacity of human dermal fibroblasts on a gene expression, protein expression and functional physiological level. Endothelial differentiation of fibroblasts was induced by culturing cells in 30% human serum, but not in fetal calf serum. Expression of proteins and genes relevant for endothelial function and differentiation was increased after induction. Furthermore, fibroblasts exposed to 30% human serum displayed increased uptake of low-density lipoprotein and formation of capillary-like networks. The results of this study may have an impact on cell sourcing for vascular tissue engineering, and the development of methods for vascularization of autologous tissue engineered constructs.
|
|
| 8. |
|
|
| 9. |
- Lundahl, Mikela, 1965, et al.
(författare)
-
Haunted museums. Ethnography, coloniality and sore points
- 2012
-
Ingår i: Eurozine.
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The troubled relationship between modernity and its colonial past haunts the ethnographic museum. But do new museums of world culture provide a plausible alternative?
|
|
| 10. |
- Ek, Martin, et al.
(författare)
-
Electron Image Series Reconstruction of Twin Interfaces in InP Superlattice Nanowires.
- 2011
-
Ingår i: Microscopy and Microanalysis. - 1435-8115. ; 17:5, s. 752-758
-
Tidskriftsartikel (refereegranskat)abstract
- The twin interface structure in twinning superlattice InP nanowires with zincblende structure has been investigated using electron exit wavefunction restoration from focal series images recorded on an aberration-corrected transmission electron microscope. By comparing the exit wavefunction phase with simulations from model structures, it was possible to determine the twin structure to be the ortho type with preserved In-P bonding order across the interface. The bending of the thin nanowires away from the intended ⟨110⟩ axis could be estimated locally from the calculated diffraction pattern, and this parameter was successfully taken into account in the simulations.
|
|
