| 1. |
- Nyström, Maria, et al.
(författare)
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Interaction of adipose-derived stem cells with active and dormant breast cancer cells
- 2023
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Ingår i: Journal of Plastic, Reconstructive & Aesthetic Surgery. - : Elsevier. - 1748-6815 .- 1878-0539. ; 83, s. 69-76
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Tidskriftsartikel (refereegranskat)abstract
- Background: Although autologous fat grafting is considered a successful method for the management of contour deformities, the fat graft could potentially induce cancer reappearance by fueling dormant breast cancer cells. Our aim was to characterize the role of adipose-derived stem cells on active and dormant breast cancer cell growth.Methods: Cobalt chloride was used to induce dormancy in MCF-7 cancer cells. Proliferation of active and dormant cancer cells was determined in the presence of adipose-derived stem cells. A proteome array was used to detect cancer-related protein expression in the cell-conditioned medium. The migration of cancer cells was measured in response to conditioned medium from the adipose-derived stem cells.Results: The adipose-derived stem cells showed variable effects on active MCF-7 cells growth and inhibited MCF-7 proliferation after the withdrawal of cobalt chloride. Of the 84 different proteins measured in the conditioned medium, only tenascin-C was differentially expressed in the co-cultures. MCF-7 cells alone did not express tenascin-C, whereas co-cultures between MCF-7 and adipose-derived stem cells expressed more tenascin-C versus adipose-derived stem cells alone. The conditioned medium from co-cultures significantly increased the migration of the cancer cells.Conclusions: Adipose-derived stem cells themselves neither increased the growth or migration of cancer cells, suggesting that autologous fat grafting may be oncologically safe if reconstruction is postponed until there is no evidence of active disease. However, interactions between adipose-derived stem cells and MCF-7 cancer cells could potentially lead to the production of factors, which further promote cancer cell migration.
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| 2. |
- Palmér, Lina, 1979-, et al.
(författare)
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Lifeworld hermeneutics: An approach and a method for research on existential issues in caring science
- 2023
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Ingår i: Scandinavian Journal of Caring Sciences. - 0283-9318 .- 1471-6712.
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Tidskriftsartikel (refereegranskat)abstract
- Background and aimThe aim of the present article was to elaborate on a research approach and method called ‘lifeworld hermeneutics’. Significant to lifeworld hermeneutics is that interpretation is the main methodological instrument for explaining and understanding existential research questions and lived experiences. From a caring science perspective, this often refers to research that aims to gain a deeper understanding of existential phenomena and issues, such as existential meaning of health, well-being, homelessness, lostness, suffering and ageing, as well as what it means to experience unhealthiness and illness, the need for care, and caring that responds to such needs.DesignTheoretical paper.ResultThe article briefly covers ontology and epistemology that clarifies the meaning and importance of a lifeworld hermeneutic attitude. This is followed by suggestions for how to perform a lifeworld hermeneutic study, expressed in relation to methodological principles for the interpretation, validation and structuring of interpretations. Thereafter, follow reflections on how to use theoretical or philosophical support to develop and deepen existential interpretations. The findings of lifeworld hermeneutic research consist of existential interpretations where the researcher, with an open and pliable attitude towards the phenomenon and the aim of the study, clarifies, explains and suggests new ways of understanding participants’ lived experiences; the researcher should maintain such an attitude towards their understanding of the phenomenon as well.ConclusionThe lifeworld hermeneutical approach and method described in this article makes it possible to further deepen the understanding and knowledge about existential issues that is relevant for caring and caring science.
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| 3. |
- Jarling, Aleksandra, et al.
(författare)
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Relationships first : Formal and informal home care of older adults in Sweden
- 2022
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Ingår i: Health & Social Care in the Community. - : Hindawi Limited. - 0966-0410 .- 1365-2524.
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Tidskriftsartikel (refereegranskat)abstract
- To a great extent, older people in Sweden, often with extensive care needs, are cared for in their own home. Support is often needed from both family and professional caregivers. This study aimed to describe and analyse different aspects of health, functioning and social networks, and how they relate to formal and informal care in the home among older adults. Analyses were performed utilising data from the OCTO-2 study, with a sample of 317 people living in Jonkoping County, aged 75, 80, 85 or 90 years, living in their own homes. Data were collected with in-person-testing. Based on receipt of care, the participants were divided into three groups: no care, informal care only, and formal care with or without informal care. Descriptive statistics and multinomial regression analysis were performed to explore the associations between received care and different aspects of health (such as multimorbidity, polypharmacy), social networks (such as loneliness, number of confidants) and functioning (such as managing daily life). The findings demonstrate that the majority of the participants received no care at home (61%). Multimorbidity and polypharmacy were more common among those receiving some kind of care in comparison to those who received no care; moreover, those receiving some kind of care also had difficulties managing daily life and less satisfaction with their social networks. The multinomial logistic regression analyses demonstrated that age, functioning in daily life, perceived general health and satisfaction with the number of confidants were related to receipt of care, but the associations among these factors differed depending on the type of care that was received. The results show the importance of a holistic perspective that includes the older person's experiences when planning home care. The results also highlight the importance of considering social perspectives and relationships in home care rather than focusing only on health factors.
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| 4. |
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| 5. |
- Palmér, Lina, 1979-, et al.
(författare)
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Caring Science With a Focus on Existential Issues in a Caring Context : A Research Area Inspired by Existential Philosophy
- 2022
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Ingår i: International journal for human caring. - 1091-5710. ; 26:3, s. 1-11
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Tidskriftsartikel (refereegranskat)abstract
- This article examines and exemplifies how existential philosophy can provide a deeper understanding of existential issues in a caring context. Existential philosophy, including lifeworld theory, is treated both as an epistemology for the development of research methods and inspiration for analysis and discussions in caring science research. The significance of the lifeworld is also highlighted as a guide to perform and enable caring and caring didactics, along with short descriptions where existential philosophy has previously influenced the development of caring science. The concept of existential caring science is suggested as a research area for research on existential and meaning-oriented phenomena.
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| 6. |
- Palmér, Lina, 1979-, et al.
(författare)
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Pre-Understanding : A Threat to Validity in Qualitative Caring Science Research?
- 2022
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Ingår i: International journal for human caring. - 1091-5710. ; 26:4, s. 1-9
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Tidskriftsartikel (refereegranskat)abstract
- This article is devoted to reflections on how to prevent pre-understanding from influencing the research process and jeopardizing the validity of a study. Influences from preunderstanding exemplified from empirical lifeworld-led caring science research. Finally, there is a discussion of preunderstanding as a natural attitude and therefore also an important part of the lifeworld. It is concluded that validity requires a self-critical approach. It is suggested that a descriptive analysis, where the findings are fairly close to the data, involves a less problematic approach than research, which requires special attention to pre-understanding in connection with different levels of interpretation.
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| 7. |
- Wetterberg, Ola, 1956, et al.
(författare)
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The University as Regeneration Strategy in an Urban Heritage Context: The Case of Roma Tre
- 2022
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Ingår i: Co-curating the City Universities and urban heritage past and future, Edited by Clare Melhuish, Henri Benesch, Dean Sully, and Ingrid Martins Holmberg. - London : UCLPress. - 9781800081826
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Bokkapitel (refereegranskat)abstract
- Roma Tre University in Rome was founded in 1992 in close collaboration between the Municipality of Rome, the Ministry of Universities and Research, and the first university, La Sapienza. The outspoken intention was to place the new university close to the city centre, utilising the old industrial districts in and around Ostiense. In this chapter, we will first outline the relationship between the establishment of the new university and the overall urban planning and the specific project in the Ostiense-Marconi area. We will then centre our attention on the slaughterhouse area and how the university processes were related to a rising and shifting discourse on industrial heritage. We will also test the concept of a permanent provisional state to characterise parts of the urban development process and look at the relationship between planned and official interventions and discourses on heritage in the area. // Co-curating the City explores the role of universities in the construction and mobilisation of heritage discourses in urban development and regeneration processes, with a focus on six case study sites: University of Gothenburg (Sweden), UCL East (London), University of Lund (Sweden). Roma Tre university (Rome), American University of Beirut, and Federal University of São Paulo, Brazil. The aim of the book is to expand the field of critical heritage studies in the urban domain, by examining the role of institutional actors both in the construction of urban heritage discourses and in how those discourses influence urban planning decisions or become instrumentalised as mechanisms for urban regeneration. It proposes that universities engage in these processes in a number of ways: as producers of urban knowledge that is mobilised to intervene in planning processes; as producers of heritage practices that are implemented in development contexts in the urban realm; and as developers engaged in campus construction projects that both reference heritage discourses as a mechanism for promoting support and approval by planners and the public, and capitalise on heritage assets as a resource. The book highlights the participatory processes through which universities are positioning themselves as significant institutions in the development of urban heritage narratives. The case studies investigate how universities, as mixed communities of interest dispersed across buildings and urban sites, engage in strategies of engagement with local people and neighbourhoods, and ask how this may be contributing to a re-shaping of ideas, narratives, and lived experience of urban heritage in which universities have a distinctive agency. The authors cross disciplinary and cultural boundaries, and bridge academia and practice.
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| 8. |
- Gillsjö, Catharina, Senior Lecturer, 1963-, et al.
(författare)
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Balance in life as a prerequisite for community-dwelling older adults' sense of health and well-being after retirement : an interview-based study
- 2021
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Ingår i: International Journal of Qualitative Studies on Health and Well-being. - : Informa UK Limited. - 1748-2623 .- 1748-2631. ; 16:1
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Tidskriftsartikel (refereegranskat)abstract
- PURPOSE This study aimed to describe community-dwelling older adults’ perceptions of health and well-being in life after retirement.METHODS This study is part of a larger project using a mixed-methods design to address lifestyles’ influence on community-dwelling older adults’ health. Individual semi-structured interviews were conducted with 18 older adults in age 70 to 95 years. Data were analysed according to a phenomenographic approach.RESULTS The results encompass four categories describing variations in community-dwelling older adults’ perceptions of health and well-being after retirement: feeling well despite illness and disease, interacting with and being useful for oneself and others, independently embracing opportunities and engaging in life, and maintaining a healthy lifestyle.CONCLUSIONS The absence of illness and disease is not a clear prerequisite for a sense of health and well-being. To promote and preserve health and well-being after retirement, older adults strived for—and coached themselves to uphold—a balance in life, focusing on not burdening others. This life orientation after retirement must be acknowledged by society at large, especially from an ageist perspective, and in health and social care to preserve and promote health and well-being.
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| 9. |
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| 10. |
- Nyström, Maria, 1988
(författare)
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Managing Ecclesiastical Heritage - Transformation of Discourses, Roles and Policy in Sweden
- 2021
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Religious heritage is in a state of transformation. Changing religious practices and secularization affect the established Christian congregations in many countries, as membership decreases and churches close. During recent years, new approaches to use and develop churches have been explored by the heritage field and the Christian congregations. A parallel development in heritage theory and policy focuses on broad definitions of heritage and questions the position of the heritage expert. In Sweden, the ecclesiastical heritage has a prominent position through heritage legislation and the shared management model of the State and Church. Departing from two case studies of projects that explore new approaches to heritage management, the purpose of the thesis is to describe how ecclesiastical heritage is constructed and understood by public heritage institutions and the Church of Sweden. In addition, the thesis aims to describe how professional and institutional roles and responsibilities are constructed and understood within the field. The case studies cover two contemporary projects involving the built ecclesiastical heritage in Sweden: the Cathedral Hill Project in Strängnäs and the Hamra Project in the village of Hamra. The projects unite actors from the public heritage field and the Church of Sweden and aim to develop and extend the use and management of the church. Adopting a qualitative approach, the material consists of interviews with key actors, documents, and observations of the case studies. Synchronic discourse analysis is applied to identify discourses on heritage and understand the roles of the actors. The results reveal parallel discourses on heritage among the actors, which are constructed through coinciding and conflicting values on the management of the past. Conflicting values may be negotiated to reach consensus, while different interpretations of governing frameworks and objectives cause tension between actors. The institutional roles and responsibilities of the key actors provide different capacities to incorporate policy strategies in practice. Despite the difficulties of balancing the objectives of the organizational framework of public heritage management, the actors use the available resources and tools to transform the boundaries of their institutional roles from within.
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