1. |
- Collier, Paul, et al.
(författare)
-
The Second World War
- 2018. - 2nd
-
Bok (refereegranskat)abstract
- The Second World War was the most devastating conflict in human history and one which provides innumerable lessons - military, political, and moral. Across the globe, both soldier and civilian endured suffering on a scale previously unknown to humanity as nations grappled with the demands of total war.
|
|
2. |
- Agarwal, Prasoon, et al.
(författare)
-
CGGBP1 mitigates cytosine methylation at repetitive DNA sequences
- 2015
-
Ingår i: BMC Genomics. - : Springer Science and Business Media LLC. - 1471-2164. ; 16
-
Tidskriftsartikel (refereegranskat)abstract
- Background: CGGBP1 is a repetitive DNA-binding transcription regulator with target sites at CpG-rich sequences such as CGG repeats and Alu-SINEs and L1-LINEs. The role of CGGBP1 as a possible mediator of CpG methylation however remains unknown. At CpG-rich sequences cytosine methylation is a major mechanism of transcriptional repression. Concordantly, gene-rich regions typically carry lower levels of CpG methylation than the repetitive elements. It is well known that at interspersed repeats Alu-SINEs and L1-LINEs high levels of CpG methylation constitute a transcriptional silencing and retrotransposon inactivating mechanism. Results: Here, we have studied genome-wide CpG methylation with or without CGGBP1-depletion. By high throughput sequencing of bisulfite-treated genomic DNA we have identified CGGBP1 to be a negative regulator of CpG methylation at repetitive DNA sequences. In addition, we have studied CpG methylation alterations on Alu and L1 retrotransposons in CGGBP1-depleted cells using a novel bisulfite-treatment and high throughput sequencing approach. Conclusions: The results clearly show that CGGBP1 is a possible bidirectional regulator of CpG methylation at Alus, and acts as a repressor of methylation at L1 retrotransposons.
|
|
3. |
- Collier, Paul, et al.
(författare)
-
Post-Conflict Risks
- 2008
-
Ingår i: Journal of Peace Research. - : SAGE Publications. - 0022-3433 .- 1460-3578. ; 45:4, s. 461-478
-
Tidskriftsartikel (refereegranskat)abstract
- Post-conflict societies face two distinctive challenges: economic recovery and reduction of the risk of a recurring conflict. Aid and policy reforms have been found to be effective in economic recovery. In this article, the authors concentrate on the other challenge — risk reduction. The post-conflict peace is typically fragile: nearly half of all civil wars are due to post-conflict relapses. The authors find that economic development substantially reduces risks, but it takes a long time. They also find evidence that UN peacekeeping expenditures significantly reduce the risk of renewed war. The effect is large: doubling expenditure reduces the risk from 40% to 31%. In contrast to these results, the authors cannot find any systematic influence of elections on the reduction of war risk. Therefore, post-conflict elections should be promoted as intrinsically desirable rather than as mechanisms for increasing the durability of the post-conflict peace. Based on these results, the authors suggest that peace appears to depend upon an external military presence sustaining a gradual economic recovery, with political design playing a somewhat subsidiary role. Since there is a relationship between the severity of post-conflict risks and the level of income at the end of the conflict, this provides a clear and uncontroversial principle for resource allocation: resources per capita should be approximately inversely proportional to the level of income in the post-conflict country.
|
|
4. |
|
|
5. |
|
|
6. |
|
|