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Excessive dietary i...
Excessive dietary intake of vitamin A is associated with reduced bone mineral density and increased risk for hip fracture
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- Melhus, Håkan (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Michaëlsson, Karl (författare)
- Uppsala universitet,Ortopedi
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Kindmark, Andreas (författare)
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Bergström, Reinhold (författare)
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Holmberg, Lars (författare)
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- Mallmin, Hans (författare)
- Uppsala universitet,Ortopedi
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- Wolk, Alicja (författare)
- Karolinska Institutet
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Ljunghall, Sverker (författare)
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(creator_code:org_t)
- American College of Physicians, 1998
- 1998
- Engelska.
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Ingår i: Annals of Internal Medicine. - : American College of Physicians. - 0003-4819 .- 1539-3704. ; 129:10, s. 770-8
- Relaterad länk:
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https://urn.kb.se/re...
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http://kipublication...
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https://doi.org/10.7...
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Abstract
Ämnesord
Stäng
- BACKGROUND: The highest incidence of osteoporotic fractures is found in northern Europe, where dietary intake of vitamin A (retinol) is unusually high. In animals, the most common adverse effect of toxic doses of retinol is spontaneous fracture. OBJECTIVE: To investigate whether excessive dietary intake of vitamin A is associated with decreased bone mineral density and increased risk for hip fracture. DESIGN: A cross-sectional study and a nested case-control study. SETTING: Two counties in central Sweden. PARTICIPANTS: For the cross-sectional study, 175 women 28 to 74 years of age were randomly selected. For the nested case-control study, 247 women who had a first hip fracture within 2 to 64 months after enrollment and 873 age-matched controls were selected from a mammography study cohort of 66,651 women 40 to 76 years of age. MEASUREMENTS: Retinol intake was estimated from dietary records and a food-frequency questionnaire. Bone mineral density was measured with dual-energy x-ray absorptiometry. Hip fracture was identified by using hospital discharge records and was confirmed by record review. RESULTS: In multivariate analysis, retinol intake was negatively associated with bone mineral density. For every 1-mg increase in daily intake of retinol, risk for hip fracture increased by 68% (95% CI, 18% to 140%; P for trend, 0.006). For intake greater than 1.5 mg/d compared with intake less than 0.5 mg/d, bone mineral density was reduced by 10% at the femoral neck (P = 0.05), 14% at the lumbar spine (P = 0.001), and 6% for the total body (P = 0.009) and risk for hip fracture was doubled (odds ratio, 2.1 [CI, 1.1 to 4.0]). CONCLUSION: High dietary intake of retinol seems to be associated with osteoporosis.
Nyckelord
- hip fracture
- bone density
- vitamin A
- hypervitaminosis A
- osteoporosis
- green leafy vegetables
- retinoic acid
- breast cancer
- A status
- resorption Norway
- 9-CIS
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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