SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "L773:0004 3591 "

Sökning: L773:0004 3591

  • Resultat 1-10 av 840
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  •  
2.
  •  
3.
  •  
4.
  •  
5.
  • Ageberg, Eva, et al. (författare)
  • Reply.
  • 2009
  • Ingår i: Arthritis and Rheumatism. - : Wiley. - 1529-0131 .- 0004-3591. ; 61:6, s. 854-854
  • Tidskriftsartikel (refereegranskat)
  •  
6.
  •  
7.
  •  
8.
  • Ahlström, Håkan, et al. (författare)
  • Magnetic resonance imaging of sacroiliac joint inflammation
  • 1990
  • Ingår i: Arthritis and Rheumatism. - 0004-3591 .- 1529-0131. ; 33:12, s. 1763-1769
  • Tidskriftsartikel (refereegranskat)abstract
    • A consecutive series of 27 patients with symptoms compatible with sacroiliitis underwent magnetic resonance imaging (MRI) of the sacroiliac joints. The diagnostic sensitivity of MRI was similar to that of computed tomography or conventional radiography. However, MRI seems to have the potential of providing unique information about the disease process in sacroiliitis by demonstrating abnormalities in subchondral bone and periarticular bone marrow. The results of this study suggest that early inflammatory changes in sacroiliitis occur in the subchondral structures of the sacroiliac joints.
  •  
9.
  • Ahmed, Aisha S., et al. (författare)
  • Attenuation of Pain and Inflammation in Adjuvant-Induced Arthritis by the Proteasome Inhibitor MG132
  • 2010
  • Ingår i: Arthritis and Rheumatism. - : Wiley. - 0004-3591 .- 1529-0131. ; 62:7, s. 2160-2169
  • Tidskriftsartikel (refereegranskat)abstract
    • Objective. In rheumatoid arthritis (RA), pain and joint destruction are initiated and propagated by the production of proinflammatory mediators. Synthesis of these mediators is regulated by the transcription factor NF-kappa B, which is controlled by the ubiquitin proteasome system (UPS). The present study explored the effects of the proteasome inhibitor MG132 on inflammation, pain, joint destruction, and expression of sensory neuropeptides as markers of neuronal response in a rat model of arthritis. Methods. Arthritis was induced in rats by injection of heat-killed Mycobacterium butyricum. Arthritis severity was scored, and nociception was evaluated by mechanical pressure applied to the hind paw. Joint destruction was assessed by radiologic and histologic analyses. NF-kappa B DNA-binding activity was analyzed by electromobility shift assay, and changes in the expression of the p50 NF-kappa B subunit and the proinflammatory neuropeptides substance P (SP) and calcitonin generelated peptide (CGRP) were detected by immunohistochemistry. Results. Arthritic rats treated with MG132 demonstrated a marked reduction in inflammation, pain, and joint destruction. The elevated DNA-binding activity of the NF-kappa B/p50 homodimer and p50, as well as the neuronal expression of SP and CGRP, observed in the ankle joints of arthritic rats were normalized after treatment with MG132. Conclusion. In arthritic rats, inhibition of proteasome reduced the severity of arthritis and reversed the pain behavior associated with joint inflammation. These effects may be mediated through the inhibition of NF-kappa B activation and may possibly involve the peripheral nervous system. New generations of nontoxic proteasome inhibitors may represent a novel pharmacotherapy for RA.
  •  
10.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 840
Typ av publikation
tidskriftsartikel (440)
konferensbidrag (396)
forskningsöversikt (4)
Typ av innehåll
övrigt vetenskapligt/konstnärligt (460)
refereegranskat (380)
Författare/redaktör
KLARESKOG, L (162)
van Vollenhoven, RF (91)
Lundberg, IE (70)
Alfredsson, L (47)
Padyukov, L (41)
Gunnarsson, I (31)
visa fler...
van Vollenhoven, R (31)
Malmstrom, V (29)
Lundberg, I (26)
Rönnblom, Lars (25)
Klareskog, Lars (25)
Catrina, AI (25)
Rantapää-Dahlqvist, ... (24)
Holmdahl, Rikard (23)
Ulfgren, AK (22)
Svenungsson, E (22)
Emery, P. (22)
Alexanderson, H (22)
van der Heijde, D (21)
Eloranta, Maija-Leen ... (20)
Sturfelt, Gunnar (19)
Ramsey-Goldman, R (19)
Wahren-Herlenius, M (19)
Rönnelid, Johan (18)
Kallberg, H (18)
Saevarsdottir, S (17)
Alarcón-Riquelme, Ma ... (16)
Dastmalchi, M (16)
Ernestam, S (16)
Bengtsson, C (16)
Andersson, U (15)
Hafstrom, I (15)
Frostegard, J (15)
Dahlqvist, Solbritt ... (15)
Askling, Johan (15)
Saxne, Tore (15)
Bratt, J (15)
Holmdahl, R (14)
Steinsson, K (14)
Plenge, RM (14)
Lampa, J (13)
Ronnelid, J (13)
Nandakumar, Kutty Se ... (13)
Nived, Ola (13)
Gregersen, PK (12)
Vencovsky, J (12)
Jakobsson, PJ (12)
af Klint, E (12)
Englund, Martin (12)
Stenstrom, CH (12)
visa färre...
Lärosäte
Karolinska Institutet (598)
Lunds universitet (126)
Uppsala universitet (100)
Umeå universitet (69)
Göteborgs universitet (29)
Högskolan i Halmstad (21)
visa fler...
Linköpings universitet (12)
Sveriges Lantbruksuniversitet (6)
Kungliga Tekniska Högskolan (4)
Örebro universitet (3)
Linnéuniversitetet (2)
Högskolan i Gävle (1)
Mälardalens universitet (1)
Jönköping University (1)
Malmö universitet (1)
Högskolan i Skövde (1)
Försvarshögskolan (1)
Sophiahemmet Högskola (1)
visa färre...
Språk
Engelska (840)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (219)
Naturvetenskap (4)
Lantbruksvetenskap (3)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy