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- Larsson, S. C., et al.
(author)
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Long-term aspirin use and colorectal cancer risk : a cohort study in Sweden
- 2006
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In: British Journal of Cancer. - Karolinska Inst, Div Nutr Epidemiol, Natl Inst Environm Med, Stockholm, Sweden. Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA. Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA 02115 USA. Harvard Univ, Sch Med, Boston, MA 02115 USA. : NATURE PUBLISHING GROUP. - 0007-0920 .- 1532-1827. ; 95:9, s. 1277-1279
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Journal article (peer-reviewed)abstract
- In a prospective cohort study of 74 250 Swedish women and men, with 7.2 years of follow-up and 705 incident colorectal cancer cases, long duration of aspirin use (420 years) was associated with a reduced risk of colorectal cancer (multivariate rate ratio: 0.65; 95% confidence interval: 0.45-0.94). Aspirin use for a shorter period was not associated with risk.
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| 3. |
- Orsini, N., et al.
(author)
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A prospective study of lifetime physical activity and prostate cancer incidence and mortality
- 2009
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In: British Journal of Cancer. - : NATURE PUBLISHING GROUP. - 0007-0920 .- 1532-1827. ; 101:11, s. 1932-1938
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Journal article (peer-reviewed)abstract
- BACKGROUND: The possible benefit of lifetime physical activity (PA) in reducing prostate cancer incidence and mortality is unclear. METHODS: A prospective cohort of 45 887 men aged 45-79 years was followed up from January 1998 to December 2007 for prostate cancer incidence (n = 2735) and to December 2006 for its subtypes and for fatal (n 190) prostate cancer. RESULTS: We observed an inverse association between lifetime (average of age 30 and 50 years, and baseline age) total PA levels and prostate cancer risk. Multivariate-adjusted incidence in the top quartile of lifetime total PA decreased by 16% (95% confidence interval (CI) = 2-27%) compared with that in the bottom quartile. We also observed an inverse association between average lifetime work or occupational activity and walking or bicycling duration and prostate cancer risk. Compared with men who mostly sit during their main work or occupation, men who sit half of the time experienced a 20% lower risk (95% CI = 7-31%). The rate ratio linearly decreased by 7% (95% CI = 1-12%) for total, 8% (95% CI = 0-16%) for localised and 12% (95% CI = 2-20%) for advanced prostate cancer for every 30 min per day increment of lifetime walking or bicycling in the range of 30 to 120 min per day. CONCLUSION: Our results suggest that not sitting for most of the time during work or occupational activity and walking or bicycling more than 30 min per day during adult life is associated with reduced incidence of prostate cancer. British Journal of Cancer (2009) 101, 1932-1938. doi:10.1038/bjc.6605404 www.bjcancer.com Published online 27 October 2009 (C) 2009 Cancer Research UK
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