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Circulating copper ...
Circulating copper and zinc levels and risk of hepatobiliary cancers in Europeans
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- Stepien, Magdalena (author)
- International Agency for Research on Cancer, World Health Organization
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- Hughes, David J (author)
- Royal College of Surgeons in Ireland
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- Hybsier, Sandra (author)
- Charité - University Medicine Berlin
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- Bamia, Christina (author)
- Hellenic Health Foundation, Athens,National and Kapodistrian University of Athens
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- Tjønneland, Anne (author)
- Danish Cancer Society
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- Overvad, Kim (author)
- Aarhus University
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- Affret, Aurélie (author)
- University of Paris-Saclay,Institut Gustave Roussy
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- His, Mathilde (author)
- University of Paris-Saclay,Institut Gustave Roussy
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- Boutron-Ruault, Marie-Christine (author)
- Institut Gustave Roussy,University of Paris-Saclay
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- Katzke, Verena (author)
- German Cancer Research Centre
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- Kühn, Tilman (author)
- German Cancer Research Centre
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Aleksandrova, Krasimira (author)
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Trichopoulou, Antonia (author)
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Lagiou, Pagona (author)
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Orfanos, Phlippos (author)
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Palli, Domenico (author)
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Sieri, Sabina (author)
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Tumino, Rosario (author)
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Ricceri, Fulvio (author)
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Panico, Salvatore (author)
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Bueno-de-Mesquita, H B As (author)
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Peeters, Petra H (author)
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- Weiderpass, Elisabete (author)
- Karolinska Institutet
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Lasheras, Cristina (author)
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Bonet Bonet, Catalina (author)
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Molina-Portillo, Elena (author)
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Dorronsoro, Miren (author)
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Huerta, José María (author)
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Barricarte, Aurelio (author)
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- Ohlsson, Bodil (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital
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- Sjöberg, Klas (author)
- Lund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups,Skåne University Hospital
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- Werner, Mårten (author)
- Umeå universitet,Umeå University,Medicin
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- Shungin, Dmitry (author)
- Umeå universitet,Umeå University,Institutionen för odontologi,Medicin
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Wareham, Nick (author)
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Khaw, Kay-Tee (author)
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Travis, Ruth C (author)
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Freisling, Heinz (author)
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- Cross, Amanda J (author)
- International Agency for Research on Cancer, World Health Organization
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Schomburg, Lutz (author)
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- Jenab, Mazda (author)
- International Agency for Research on Cancer, World Health Organization
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(creator_code:org_t)
- 2017-02-02
- 2017
- English 9 s.
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In: British Journal of Cancer. - : Springer Science and Business Media LLC. - 1532-1827 .- 0007-0920. ; 116:5, s. 688-696
- Related links:
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http://dx.doi.org/10... (free)
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https://www.nature.c...
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https://umu.diva-por... (primary) (Raw object)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Subject headings
Close
- BACKGROUND: Copper and zinc are essential micronutrients and cofactors of many enzymatic reactions that may be involved in liver-cancer development. We aimed to assess pre-diagnostic circulating levels of copper, zinc and their ratio (Cu/Zn) in relation to hepatocellular carcinoma (HCC), intrahepatic bile duct (IHBD) and gall bladder and biliary tract (GBTC) cancers.METHODS: A nested case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort. Serum zinc and copper levels were measured in baseline blood samples by total reflection X-ray fluorescence in cancer cases (HCC n=106, IHDB n=34, GBTC n=96) and their matched controls (1:1). The Cu/Zn ratio, an indicator of the balance between the micronutrients, was computed. Multivariable adjusted odds ratios and 95% confidence intervals (OR; 95% CI) were used to estimate cancer risk.RESULTS: For HCC, the highest vs lowest tertile showed a strong inverse association for zinc (OR=0.36; 95% CI: 0.13-0.98, Ptrend=0.0123), but no association for copper (OR=1.06; 95% CI: 0.45-2.46, Ptrend=0.8878) in multivariable models. The calculated Cu/Zn ratio showed a positive association for HCC (OR=4.63; 95% CI: 1.41-15.27, Ptrend=0.0135). For IHBC and GBTC, no significant associations were observed.CONCLUSIONS: Zinc may have a role in preventing liver-cancer development, but this finding requires further investigation in other settings.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- Aged
- Biliary Tract Neoplasms/epidemiology
- Carcinoma, Hepatocellular/epidemiology
- Case-Control Studies
- Copper/blood
- Europe/epidemiology
- Female
- Humans
- Liver Neoplasms/epidemiology
- Male
- Middle Aged
- Prospective Studies
- Zinc/blood
- copper
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
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Stepien, Magdale ...
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Hughes, David J
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Hybsier, Sandra
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Bamia, Christina
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Tjønneland, Anne
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Overvad, Kim
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show more...
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Affret, Aurélie
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His, Mathilde
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Boutron-Ruault, ...
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Katzke, Verena
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Kühn, Tilman
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Aleksandrova, Kr ...
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Trichopoulou, An ...
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Lagiou, Pagona
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Orfanos, Phlippo ...
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Palli, Domenico
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Sieri, Sabina
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Tumino, Rosario
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Ricceri, Fulvio
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Panico, Salvator ...
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Bueno-de-Mesquit ...
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Peeters, Petra H
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Weiderpass, Elis ...
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Lasheras, Cristi ...
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Bonet Bonet, Cat ...
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Molina-Portillo, ...
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Dorronsoro, Mire ...
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Huerta, José Mar ...
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Barricarte, Aure ...
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Ohlsson, Bodil
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Sjöberg, Klas
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Werner, Mårten
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Shungin, Dmitry
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Wareham, Nick
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Khaw, Kay-Tee
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Travis, Ruth C
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Freisling, Heinz
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Cross, Amanda J
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Schomburg, Lutz
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Jenab, Mazda
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
- Articles in the publication
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British Journal ...
- By the university
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Lund University
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Umeå University
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Karolinska Institutet