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Träfflista för sökning "L773:0014 2956 ;pers:(Lundblad Arne)"

Sökning: L773:0014 2956 > Lundblad Arne

  • Resultat 1-4 av 4
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1.
  • Chester, Alan, et al. (författare)
  • Biosynthesis of the blood-group-B-specific trisaccharide in a rhesus monkey
  • 1977
  • Ingår i: European Journal of Biochemistry. - 0014-2956. ; 77:1, s. 87-91
  • Tidskriftsartikel (refereegranskat)abstract
    • A Rhesus monkey, serologically grouped as B, has been shown to excrete low-molecular-weight carbohydrate material in urine closely related to that found in human urine. Galactose feeding resulted in the excretion of a trisaccharide which was shown to be identical to the trisaccharide isolated from the urine of group B humans under the same conditions. Experiments in which [14C]galactose was administered both orally and via an intestinal vein demonstrated that the intestine is the site of biosynthesis.
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2.
  • Chester, Alan, et al. (författare)
  • Urinary excretion of oligosaccharides induced by galactose given orally or intravenously
  • 1979
  • Ingår i: European Journal of Biochemistry. - 0014-2956. ; 100:2, s. 385-392
  • Tidskriftsartikel (refereegranskat)abstract
    • The effect of oral administration of galactose, lactose, and sucrose and intravenous injection of galactose on the urinary excretion of blood-group-active oligosaccharides has been studied. Galactose given either as the free sugar, a glycoside (lactose) or a constituent of normal diet was an absolute requirement for the formation and excretion of A-trisaccharide, B-trisaccharide and 2'-fucosylgalactose in blood group A, B and O(H) secretors, respectively. Great individual variation was seen in the amounts of galactose-dependent oligosaccharides excreted. Injection of galactose resulted in excretion of 3-59% of the amount of oligosaccharide formed after oral administration to the same individual. The mean ratio A-trisaccharide/B-trisaccharide was 2.7 in four blood-group-A1B secretors and 0.22 in three A2B secretors and can thus serve as a parameter for chemical differentiation between the two blood groups. The excretion of larger blood-group-active oligosaccharides, including the A-pentasaccharide, the B-pentasaccharide and lactodifucotetraose, that are normal components in urine from, respectively, starved A, B, and H secretors, was about the same after oral administration of galactose or lactose. The B-trisaccharide was the only oligosaccharide detected in plasma after oral galactose administration to a blood-group-B secretor individual. The concentration was 0.38 mg/l of plasma.
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3.
  • Renlund, Martin, et al. (författare)
  • Free N-acetylneuraminic acid in tissues in Salla disease and the enzymes involved in its metabolism
  • 1983
  • Ingår i: European Journal of Biochemistry. - : Wiley. - 0014-2956 .- 1432-1033. ; 130:1, s. 39-45
  • Tidskriftsartikel (refereegranskat)abstract
    • Salla disease is a lysosomal storage disorder of unknown etiology, characterized biochemically by increased urinary excretion of N-acetylneuraminic acid. This compound has now been shown to occur in abnormally large amounts in liver and cultured skin fibroblasts from these patients. Quantification of N-acetylneuraminic acid was performed using a new gas-chromatography/mass spectrometric single-ion method which is sensitive and specific. No abnormalities in the activity of several enzymes involved in sialic acid metabolism (N-acetylneuraminate:pyruvate lyase, neuraminidase, CMP-N-acetylneuraminate N-acylneuraminohydrolase and CTP:N-acyl-neuraminate cytidylyltransferase) were demonstrable. A possible explanation for the defect is a malfunctioning active transport of N-acetylneuraminic acid across the lysosomal membrane.
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4.
  • Renlund, Martin, et al. (författare)
  • Increased urinary excretion of free N-acetylneuraminic acid in thirteen patients with Salla disease
  • 1979
  • Ingår i: European Journal of Biochemistry. - 0014-2956. ; 101:1, s. 245-250
  • Tidskriftsartikel (refereegranskat)abstract
    • Thirteen severely retarded patients with Salla disease, a new type of lysosomal storage disorder, have been studied biochemically. All patients excreted approximately ten times more free sialic acid than normal individuals. The isolated sialic acid was characterized by paper chromatography, thin-layer chromatography, optical rotation, 13C and 1H nuclear magnetic resonance spectroscopy, and mass spectrometry of its permethylated derivative. The results clearly indicated that the excreted sialic acid was identical to N-acetylneuraminic acid. The main sialylated trisaccharide present in the urine of the patients was identified as 3'-sialyllactose by sugar and methylation analysis. The excreted amounts were found to be within normal range.
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  • Resultat 1-4 av 4

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