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Th17 development an...
Th17 development and autoimmune arthritis in the absence of reactive oxygen species
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- George-Chandy, Annie, 1969 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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- Nordström, Inger, 1958 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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- Nygren, Erik (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,University of Gothenburg, Sweden
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- Jonsson, Ing-Marie, 1949 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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- Postigo, J. (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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- Collins, Vincent, 1962 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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- Eriksson, Kristina, 1962 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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(creator_code:org_t)
- Wiley, 2008
- 2008
- Engelska.
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Ingår i: European Journal of Immunology. - : Wiley. - 0014-2980 .- 1521-4141. ; 38:4, s. 1118-1126
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Dendritic cells (DC) express a functional NADPH oxidase and produce reactive oxygen species (ROS) upon interaction with microbes and T cells. Exposure to ROS leads to DC activation and maturation, as evidenced by phenotypic and functional changes. We have evaluated how endogenous ROS production affects the cytokine secretion pattern and T cell-activating capacity of bone marrow-derived murine DC. DC treated with ROS scavengers, as well as DC from mice that lack a functional NADPH oxidase (and thereby inherently deficient in ROS production) produced significantly increased levels of IL-1β, IL-6, TNF-α and TGF-β in response to microbial activation. DC deficient in ROS production induced high levels of IFN-γ and IL-17 in responding T cells after Ag-specific or superantigen-induced activation. Finally, we show that ROS deficiency affected the induction of a T cell-dependent inflammatory condition, collagen-induced arthritis (CIA). C57BL/6 mice that lack a functional NADPH oxidase developed a severe and erosive CD4-dependent CIA, whereas the majority of the congenic wild-type animals remained healthy. These data suggest that ROS act as immunomodulators in DC-driven T cell activation and perhaps also in T cell-dependent immunopathology.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- CD4+ T cells
- Cytokines
- Dendritic cells
- Immune regulation
- Rheumatology
- interleukin 1beta
- reactive oxygen metabolite
- reduced nicotinamide adenine dinucleotide phosphate dehydrogenase
- transforming growth factor beta
- tumor necrosis factor alpha
- collagen type 2
- gamma interferon
- interleukin 17
- reduced nicotinamide adenine dinucleotide phosphate oxidase
- animal cell
- animal experiment
- animal tissue
- antibody production
- arthritis
- article
- autoimmune disease
- CD4+ T lymphocyte
- cell activation
- cell maturation
- cell strain
- controlled study
- cytokine release
- dendritic cell
- helper cell
- immune response
- immunomodulation
- immunopathogenesis
- male
- mouse
- nonhuman
- priority journal
- protein function
- T lymphocyte activation
- th17 cell
- animal
- biosynthesis
- C57BL mouse
- chronic granulomatous disease
- genetics
- immunology
- metabolism
- mouse mutant
- phenotype
- Animals
- Autoimmune Diseases
- Collagen Type II
- Granulomatous Disease
- Chronic
- Interferon Type II
- Interleukin-17
- Mice
- Mice
- Inbred C57BL
- Mice
- Knockout
- NADPH Oxidase
- Reactive Oxygen Species
- T-Lymphocytes
- Helper-Inducer
- Animals
- Arthritis
- metabolism
- Autoimmune Diseases
- immunology
- Collagen Type II
- Dendritic Cells
- Granulomatous Disease
- Chronic
- Interferon Type II
- biosynthesis
- Interleukin-17
- Male
- Mice
- Inbred C57BL
- Knockout
- NADPH Oxidase
- deficiency
- genetics
- Phenotype
- Reactive Oxygen Species
- T-Lymphocytes
- Helper-Inducer
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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