SwePub
Tyck till om SwePub Sök här!
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "L773:0022 3050 "

Sökning: L773:0022 3050

  • Resultat 1-10 av 294
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  •  
2.
  •  
3.
  •  
4.
  •  
5.
  •  
6.
  •  
7.
  •  
8.
  • Adams, David, et al. (författare)
  • Phase 2 open-label extension study of patisiran, an investigational RNAi therapeutic for the treatment of familial amyloid polyneuropathy
  • 2015
  • Ingår i: Journal of Neurology, Neurosurgery and Psychiatry. - : BMJ. - 0022-3050 .- 1468-330X. ; 86:11
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • Familial amyloid polyneuropathy (FAP) is a progressive disease. Patisiran is an investigational small interfering RNA (siRNA) targeting TTR. The primary objective of the Phase 2 study is to evaluate the safety of 0.3 mg/kg patisiran administered intravenously once every 3 weeks. Twenty-seven patients were enrolled; the mean duration of treatment was 7 months (range 3–12), with 282 doses administered (median of 11 doses/patient). Chronic dosing with patisiran has been generally well tolerated. Two patients experienced serious adverse events regarded as being unrelated to study drug. Infusion-related reactions were observed in 14.8% of the patients, were mild in severity, and did not result in any discontinuations. Sustained TTR lowering of at least 80% was achieved based on serial TTR measurements for over 9 months, with further nadir of up to 89.6% between doses. Neurologic impairment scores were stable after 6 months of treatment with patisiran. A mean decrease from baseline in mNIS+7 of 0.95 points (N=19) observed in this study compared favorably to the estimated increase of 7–10 points in mNIS+7 at 6 months from prior FAP studies in a patient population with similar baseline NIS values. Dosing continues in all patients, and 12–month results will be presented.
  •  
9.
  • Adelow, C, et al. (författare)
  • Epilepsy as a risk factor for cancer
  • 2006
  • Ingår i: Journal of neurology, neurosurgery, and psychiatry. - : BMJ. - 1468-330X .- 0022-3050. ; 77:6, s. 784-786
  • Tidskriftsartikel (refereegranskat)
  •  
10.
  • Ahmed, R. M., et al. (författare)
  • Biomarkers in dementia: clinical utility and new directions
  • 2014
  • Ingår i: Journal of Neurology Neurosurgery and Psychiatry. - : BMJ. - 0022-3050 .- 1468-330X. ; 85:12, s. 1426-1434
  • Tidskriftsartikel (refereegranskat)abstract
    • Imaging, cerebrospinal fluid (CSF) and blood-based biomarkers have the potential to improve the accuracy by which specific causes of dementia can be diagnosed in vivo, provide insights into the underlying pathophysiology, and may be used as inclusion criteria and outcome measures for clinical trials. While a number of imaging and CSF biomarkers are currently used for each of these purposes, this is an evolving field, with numerous potential biomarkers in varying stages of research and development. We review the currently available biomarkers for the three most common forms of neurodegenerative dementia, and give an overview of research techniques that may in due course make their way into the clinic.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 294
Typ av publikation
tidskriftsartikel (257)
konferensbidrag (34)
forskningsöversikt (3)
Typ av innehåll
refereegranskat (240)
övrigt vetenskapligt/konstnärligt (54)
Författare/redaktör
Zetterberg, Henrik, ... (36)
Blennow, Kaj, 1958 (19)
Graff, C (12)
Galimberti, D (12)
Aarsland, D (11)
Olsson, T (11)
visa fler...
Borroni, B. (11)
Rohrer, JD (11)
Masellis, M (10)
Otto, M. (10)
Sánchez-Valle, R (10)
Synofzik, M (10)
van Swieten, JC (10)
Tartaglia, MC (10)
Vandenberghe, R (9)
Wikkelsö, Carsten, 1 ... (9)
Levin, J (9)
Rowe, JB (9)
Moreno, F (9)
de Mendonça, A (9)
Ducharme, S (9)
Finger, E (9)
Santana, I (9)
Gerhard, A (9)
Laforce, R (9)
Winblad, B (8)
Hillert, J (8)
Wallin, Anders, 1950 (8)
Tagliavini, F (8)
Ludolph, Albert C. (8)
Sorbi, S (8)
Butler, CR (8)
Danek, A (8)
Wahlund, LO (7)
Svenningsson, P (6)
Andersen, Peter M. (6)
Andersen, Peter M., ... (6)
Weydt, Patrick (6)
Otto, Markus (5)
Olsson, Tomas (5)
Hagell, Peter (5)
Fazekas, F. (5)
Hariz, Marwan (5)
Heslegrave, Amanda J (5)
Tisell, Magnus, 1964 (5)
Scheltens, P (5)
Frisoni, G (5)
Pantoni, L (5)
Frisén, Lars, 1939 (5)
Jiskoot, LC (5)
visa färre...
Lärosäte
Karolinska Institutet (152)
Göteborgs universitet (80)
Umeå universitet (52)
Lunds universitet (45)
Linköpings universitet (18)
Uppsala universitet (17)
visa fler...
Örebro universitet (11)
Stockholms universitet (3)
Luleå tekniska universitet (2)
Högskolan Kristianstad (1)
Jönköping University (1)
Handelshögskolan i Stockholm (1)
Chalmers tekniska högskola (1)
Marie Cederschiöld högskola (1)
visa färre...
Språk
Engelska (293)
Odefinierat språk (1)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (161)
Naturvetenskap (2)
Teknik (2)
Samhällsvetenskap (2)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy