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  • Fasth, A., et al. (författare)
  • Reumatiska sjukdomar hos barn viktigt specialområde : benmärgstransplantation ger ökat hopp för de svårast sjuka
  • 2000
  • Ingår i: Läkartidningen. - 0023-7205. - 0023-7205 (Print) 0023-7205 (Linking) ; 97:24, s. 2968-2973
  • Tidskriftsartikel (refereegranskat)abstract
    • Chronic inflammatory joint disorders can be viewed as a spectrum of disease presenting one set of characteristics during childhood and another in adulthood. Few of the disorders are specific for children of a specific age, even if some conditions might be very rare in certain age groups. Juvenile idiopathic arthritis is a new name suggested for pediatric chronic inflammatory joint disorders. Drug therapy is based on the same principles as for adults: an aggressive approach with NSAID-drugs and low dose methotrexate in combination with local steroid injections. New drugs like TNF-blockade and COX-2 inhibitors are almost untested in children, with the exception of etanercept which has been studied in children with polyarticular disease and proven to be very effective. For rare cases with very severe joint disease hematopoietic stem cell transplantation is under evaluation.
  • Aagaard, P., et al. (författare)
  • Early repolarization in ECG. Definition, prevalence and prognostic significance
  • 2015
  • Ingår i: Läkartidningen. - 0023-7205. ; 112
  • Tidskriftsartikel (refereegranskat)abstract
    • Early repolarization defined as antero-lateral ST-segment elevation exists in 1-2 % of the general population and has been considered a benign ECG finding for decades. However, early repolarization, defined as infero-lateral J-waves, has in recent studies been associated with an increased - albeit low - risk of sudden and cardiovascular death. This ECG pattern is present in 3-13% of the general population. However, exercise training can induce all types of early repolarization, and the prevalence in the athletic population rises to 20-90%. There is large variability between sports (higher in endurance athletes) and also throughout the season (higher during times of peak fitness). In athletes, early repolarization, regardless of type, is considered benign. In asymptomatic non-athletes, the absolute risk is too low to use this ECG finding in clinical practice. In individuals with J-wave syndrome, on the other hand, ICD implantation should be strongly considered to prevent sudden cardiac death.
  • Abdon, NJ, et al. (författare)
  • Peripartumcardiomyopathi an often mised diagnosis
  • 2013
  • Ingår i: Läkartidningen. - Läkartidningen Förlag AB. - 0023-7205. ; 110:23-24, s. 1152-1154
  • Tidskriftsartikel (refereegranskat)abstract
    • Peripartumkardiomyopati är en sällsynt form av hjärtsvikt. Diagnostiska kriterier är nytillkommen hjärtsvikt från sen graviditet och upp till fem månader efter förlossning, avsaknad av annan förklaring till hjärtsvikt och nedsatt systolisk vänsterkammarfunktion Orsaken till tillståndet tros vara omvandling av prolaktin till en kardiotoxisk variant. Terapin är den etablerade, men ACE-hämmare och ARB får inte ges till ammande mödrar. Hjärttransplantation har tillgripits. Maligna hjärtarytmier har krävt behandling med implanterbar defibrillator och pacemaker. Hämning av produktionen av prolaktin med bromokriptin har gett goda resultat i en liten studie. Resultaten har inte bekräftats.
  • Abrahamsson, Maths, 1953-, et al. (författare)
  • [Dim the light! Glare problems in a world with ever increasing demands on visual acuity] Blända av!
  • 1997
  • Ingår i: Läkartidningen. - 0023-7205. ; 94:41, s. 3607-11
  • Tidskriftsartikel (övrigt vetenskapligt)abstract
    • Ocular tissue transparency is dependent on the regular lattice configuration of lens and corneal fibres of uniform diameter. Ageing is associated with degeneration of both lens and cornea, which lose some of their structural order and eventually their transparency, though this process is not uniform. The structural changes are local and result in ocular media opacities. When the opacities increase in number and extension, they begin to affect visual acuity. As the loss of acuity becomes clinically significant, we speak of clinically relevant cataract. Retinal exposure to light diffused by intraocular light scattering induces optical glare, one of two forms of glare. The other form is transient glare--i.e., glare due to adaptation problems in an environment with rapidly changing ambient luminance. Contemporary society is characterised by increasing emphasis on visual information in such forms as texts, icons, signs and symbols. The computer revolution has been accompanied by further stress on the importance of the detection and interpretation of written instructions.
  • Acosta, Stefan, et al. (författare)
  • Fallbeskrivning. Endometrios orsakade kolonileus, uretärobstruktion och hypertoni
  • 2001
  • Ingår i: Läkartidningen. - Swedish Medical Association. - 0023-7205. ; 98:18, s. 2208-2212
  • Tidskriftsartikel (refereegranskat)abstract
    • Laparoscopy and palpation offer only a rough estimate of the extent of endometriosis. Consequently, endometriosis involving the bowels and urinary tract is under-diagnosed. Bowel obstruction and retroperitoneal endometriosis with obstruction of the ureter are uncommon conditions, but awareness of them is important. Ureteric obstruction develops slowly from periureteral fibrosis and often results in an asymptomatic hydronephrosis, loss of renal function and hypertension. Although renography is the first line of choice in investigation of the upper urinary tract in cases of suspected ureteric obstruction, ultrasound of the kidneys may be useful in the hands of the experienced gynecologist as a screening tool at consultation. The rationale for this recommendation is that ureteric obstruction and hydronephrosis often occur simultaneously. We present a case with bowel obstruction mimicking sigmoid carcinoma, ureteric obstruction and hypertension, caused by endometriosis, where the diagnostic difficulties are illustrated. Collaboration between gynecologist and urologist is essential in selected cases of endometriosis.
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