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Histological improvement of liver fibrosis in well-treated patients with autoimmune hepatitis : A cohort study

Danielsson Borssén, Åsa, 1977- (author)
Umeå universitet,Medicin,Norrland University Hospital,Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden.,Umeå University, Sweden
Palmqvist, Richard (author)
Umeå University,Umeå universitet,Patologi,Umea Univ, Dept Med Biosci, Pathol, Umea, Sweden.,Umeå University, Sweden
Kechagias, Stergios (author)
Linköpings universitet,Linköping University,Linkoping Univ, Dept Med & Hlth Sci, Dept Gastroenterol & Hepatol, Linkoping, Sweden.,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Magtarmmedicinska kliniken
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Marschall, Hanns-Ulrich (author)
Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Dept Mol & Clin Med, Inst Med, Sahlgrenska Acad, Gothenburg, Sweden.
Bergquist, Annika (author)
Karolinska Institutet
Rorsman, Fredrik (author)
Uppsala universitet,Uppsala University,Gastroenterologi/hepatologi,Uppsala University, Sweden
Weiland, Ola (author)
Karolinska Institutet
Verbaan, Hans (author)
Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Gastroenterol Div, Dept Clin Sci, Univ Hosp Skane, Lund, Sweden.,Lund University, Sweden
Nyhlin, Nils, 1971- (author)
Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Gastroenterology, Örebro University Hospital, Örebro, Sweden,Department of Medicine, Section of Hepatology and Gastroenterology, Örebro University Hospital and Faculty of Medicine and Health, Örebro University,Orebro Univ, Dept Gastroenterol, Fac Med & Hlth, Orebro, Sweden.
Nilsson, Emma (author)
Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Gastroenterol Div, Dept Clin Sci, Univ Hosp Skane, Lund, Sweden.,Lund University, Sweden
Werner, Mårten (author)
Umeå universitet,Medicin,Norrland University Hospital,Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden.,Umeå University, Sweden
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 (creator_code:org_t)
Lippincott Williams & Wilkins, 2017
2017
English.
In: Medicine. - : Lippincott Williams & Wilkins. - 0025-7974 .- 1536-5964. ; 96:34
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Autoimmune hepatitis (AIH) is a chronic autoimmune liver disease that if left untreated may lead to the development of cirrhosis. Previous studies on AIH patients have suggested that fibrosis and even cirrhosis can be reversed by medical treatment. The aim of this study was to evaluate the efficacy of medical treatment for protection of developing fibrosis and cirrhosis.A total of 258 liver biopsies from 101 patients (72 women, 29 men) were analyzed by a single pathologist and classified according to the Ishak grading (inflammation) and staging (fibrosis) system. Liver histology was stratified according to the temporal changes of fibrosis stage (increased, decreased, or stable), and groups were compared.Complete or partial response to medical treatment was 94.9%. Reduction of fibrosis stage from the first to the last biopsy was seen in 63 patients (62.4%). We found an association between a reduction in the fibrosis stage and continuous glucocorticoid medication, as well as lowered scores of inflammation at last biopsy. Twenty-one patients had cirrhosis (Ishak stage 6) at least in one of the previous biopsies, but only 5 patients at the last biopsy.Histological improvement is common in AIH patients that respond to medical treatment, and a reduction or stabilization of fibrosis stage occurs in about 2/3 of such patients.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Gastroenterologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Allmänmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- General Practice (hsv//eng)

Keyword

autoimmune hepatitis
autoimmune liver disease
cirrhosis
fibrosis
inflammation
autoimmune hepatitis
autoimmune liver disease
cirrhosis
fibrosis
inflammation

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ref (subject category)
art (subject category)

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