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Nitric oxide permit...
Nitric oxide permits hypoxia-induced lymphatic perfusion by controlling arterial-lymphatic conduits in zebrafish and glass catfish
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- Jensen, Lasse Dahl (författare)
- Karolinska Institute, Stockholm, Sweden
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- Cao, Renhai (författare)
- Karolinska Institutet
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- Hedlund, Eva-Maria (författare)
- Karolinska Institutet
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- Söll, Iris (författare)
- Södertörns högskola,Molekylärbiologi,Södertörn University and BioNut, Karolinska Institute, Huddinge, Sweden
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- Lundberg, Jon O. (författare)
- Karolinska Institutet
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- Hauptmann, Giselbert (författare)
- Södertörns högskola,Molekylärbiologi,Södertörn University and BioNut, Karolinska Institute, Huddinge, Sweden
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- Steffensen, John Fleng (författare)
- University of Copenhagen, Helsingor, Denmark
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- Cao, Yihai (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2009-10-27
- 2009
- Engelska.
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 106:43, s. 18408-18413
- Relaterad länk:
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http://www.pnas.org/...
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The blood and lymphatic vasculatures are structurally and functionally coupled in controlling tissue perfusion, extracellular interstitial fluids, and immune surveillance. Little is known, however, about the molecular mechanisms that underlie the regulation of bloodlymphatic vessel connections and lymphatic perfusion. Here we show in the adult zebrafish and glass catfish (Kryptopterus bicirrhis) that blood-lymphatic conduits directly connect arterial vessels to the lymphatic system. Under hypoxic conditions, arterial-lymphatic conduits (ALCs) became highly dilated and linearized by NO-induced vascular relaxation, which led to blood perfusion into the lymphatic system. NO blockage almost completely abrogated hypoxia-induced ALC relaxation and lymphatic perfusion. These findings uncover mechanisms underlying hypoxia-induced oxygen compensation by perfusion of existing lymphatics in fish. Our results might also imply that the hypoxia-induced NO pathway contributes to development of progression of pathologies, including promotion of lymphatic metastasis by modulating arterial-lymphatic conduits, in the mammalian system.
Ämnesord
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Nyckelord
- blood vessel
- hatic vessel
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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