SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "L773:0028 0836 OR L773:1476 4687 srt2:(2010-2019);srt2:(2010)"

Sökning: L773:0028 0836 OR L773:1476 4687 > (2010-2019) > (2010)

  • Resultat 21-30 av 62
  • Föregående 12[3]4567Nästa
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
21.
  • Hudson, Thomas J., et al. (författare)
  • International network of cancer genome projects
  • 2010
  • Ingår i: Nature. - 0028-0836 .- 1476-4687. ; 464:7291, s. 993-998
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumours from 50 different cancer types and/or subtypes that are of clinical and societal importance across the globe. Systematic studies of more than 25,000 cancer genomes at the genomic, epigenomic and transcriptomic levels will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies.</p>
  •  
22.
  • Lassance, J-M, et al. (författare)
  • Allelic variation in a fatty-acyl reductase gene causes divergence in moth sex pheromones
  • 2010
  • Ingår i: Nature. - 0028-0836 .- 1476-4687. ; 466:7305, s. 486-489
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Pheromone-based behaviours are crucial in animals from insects to mammals, and reproductive isolation is often based on pheromone differences. However, the genetic mechanisms by which pheromone signals change during the evolution of new species are largely unknown. In the sexual communication system of moths (Insecta: Lepidoptera), females emit a species-specific pheromone blend that attracts males over long distances. The European corn borer, Ostrinia nubilalis, consists of two sex pheromone races, Z and E, that use different ratios of the cis and trans isomers of acetate pheromone components. This subtle difference leads to strong reproductive isolation in the field between the two races, which could represent a first step in speciation. Female sex pheromone production and male behavioural response are under the control of different major genes, but the identity of these genes is unknown. Here we show that allelic variation in a fatty-acyl reductase gene essential for pheromone biosynthesis accounts for the phenotypic variation in female pheromone production, leading to race-specific signals. Both the cis and trans isomers of the pheromone precursors are produced by both races, but the precursors are differentially reduced to yield opposite ratios in the final pheromone blend as a result of the substrate specificity of the enzymes encoded by the Z and E alleles. This is the first functional characterization of a gene contributing to intraspecific behavioural reproductive isolation in moths, highlighting the importance of evolutionary diversification in a lepidopteran-specific family of reductases. Accumulation of substitutions in the coding region of a single biosynthetic enzyme can produce pheromone differences resulting in reproductive isolation, with speciation as a potential end result.</p><p> </p><p> </p>
  •  
23.
  • Ljung, Karin, et al. (författare)
  • Hormonal control of the shoot stem-cell niche
  • 2010
  • Ingår i: Nature. - Nature Publishing Group. - 0028-0836 .- 1476-4687. ; 465, s. 1089-U154
  • Tidskriftsartikel (refereegranskat)abstract
    • The classic phytohormones cytokinin and auxin play essential roles in the maintenance of stem-cell systems embedded in shoot and root meristems, and exhibit complex functional interactions(1-4). Here we show that the activity of both hormones directly converges on the promoters of two A-type ARABIDOPSIS RESPONSE REGULATOR (ARR) genes, ARR7 and ARR15, which are negative regulators of cytokinin signalling(5) and have important meristematic functions(3). Whereas ARR7 and ARR15 expression in the shoot apical meristem (SAM) is induced by cytokinin, auxin has a negative effect, which is, at least in part, mediated by the AUXIN RESPONSE FACTOR5/MONOPTEROS (MP) transcription factor(6). Our results provide a mechanistic framework for hormonal control of the apical stem-cell niche and demonstrate how root and shoot stem-cell systems differ in their response to phytohormones.
  •  
24.
  • Maeda, K., et al. (författare)
  • An asymmetric explosion as the origin of spectral evolution diversity in type Ia supernovae
  • 2010
  • Ingår i: Nature. - 0028-0836 .- 1476-4687. ; 466:7302, s. 82-85
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Type Ia supernovae form an observationally uniform class of stellar explosions, in that more luminous objects have smaller decline-rates. This one-parameter behaviour allows type Ia supernovae to be calibrated as cosmological `standard candles', and led to the discovery of an accelerating Universe. Recent investigations, however, have revealed that the true nature of type Ia supernovae is more complicated. Theoretically, it has been suggested that the initial thermonuclear sparks are ignited at an offset from the centre of the white-dwarf progenitor, possibly as a result of convection before the explosion. Observationally, the diversity seen in the spectral evolution of type Ia supernovae beyond the luminosity-decline-rate relation is an unresolved issue. Here we report that the spectral diversity is a consequence of random directions from which an asymmetric explosion is viewed. Our findings suggest that the spectral evolution diversity is no longer a concern when using type Ia supernovae as cosmological standard candles. Furthermore, this indicates that ignition at an offset from the centre is a generic feature of type Ia supernovae.</p>
  •  
25.
  • Marteyn, Benoit, et al. (författare)
  • Modulation of Shigella virulence in response to available oxygen in vivo
  • 2010
  • Ingår i: Nature. - 0028-0836 .- 1476-4687. ; 465:7296, s. 355-358
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Bacteria coordinate expression of virulence determinants in response to localized microenvironments in their hosts. Here we show that Shigella flexneri, which causes dysentery, encounters varying oxygen concentrations in the gastrointestinal tract, which govern activity of its type three secretion system (T3SS). The T3SS is essential for cell invasion and virulence(1). In anaerobic environments (for example, the gastrointestinal tract lumen), Shigella is primed for invasion and expresses extended T3SS needles while reducing Ipa (invasion plasmid antigen) effector secretion. This is mediated by FNR (fumarate and nitrate reduction), a regulator of anaerobic metabolism that represses transcription of spa32 and spa33, virulence genes that regulate secretion through the T3SS. We demonstrate there is a zone of relative oxygenation adjacent to the gastrointestinal tract mucosa, caused by diffusion from the capillary network at the tips of villi. This would reverse the anaerobic block of Ipa secretion, allowing T3SS activation at its precise site of action, enhancing invasion and virulence.</p>
  •  
26.
  • Marteyn, Benoit, et al. (författare)
  • Modulation of Shigella virulence in response to available oxygen in vivo
  • 2010
  • Ingår i: Nature. - 0028-0836 .- 1476-4687. ; 465:7296, s. 355-358
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Bacteria coordinate expression of virulence determinants in response to localized microenvironments in their hosts. Here we show that Shigella flexneri, which causes dysentery, encounters varying oxygen concentrations in the gastrointestinal tract, which govern activity of its type three secretion system (T3SS). The T3SS is essential for cell invasion and virulence(1). In anaerobic environments (for example, the gastrointestinal tract lumen), Shigella is primed for invasion and expresses extended T3SS needles while reducing Ipa (invasion plasmid antigen) effector secretion. This is mediated by FNR (fumarate and nitrate reduction), a regulator of anaerobic metabolism that represses transcription of spa32 and spa33, virulence genes that regulate secretion through the T3SS. We demonstrate there is a zone of relative oxygenation adjacent to the gastrointestinal tract mucosa, caused by diffusion from the capillary network at the tips of villi. This would reverse the anaerobic block of Ipa secretion, allowing T3SS activation at its precise site of action, enhancing invasion and virulence.</p>
  •  
27.
  • Niedzwiedzki, Grzegorz, et al. (författare)
  • Tetrapod trackways from the early Middle Devonian period of Poland
  • 2010
  • Ingår i: Nature. - Nature Publishing Group. - 0028-0836 .- 1476-4687. ; 463:7277, s. 43-48
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>The fossil record of the earliest tetrapods (vertebrates with limbs rather than paired fins) consists of body fossils and trackways. The earliest body fossils of tetrapods date to the Late Devonian period (late Frasnian stage) and are preceded by transitional elpistostegids such as Panderichthys and Tiktaalik that still have paired fins. Claims of tetrapod trackways predating these body fossils have remained controversial with regard to both age and the identity of the track makers. Here we present well-preserved and securely dated tetrapod tracks from Polish marine tidal flat sediments of early Middle Devonian (Eifelian stage) age that are approximately 18 million years older than the earliest tetrapod body fossils and 10 million years earlier than the oldest elpistostegids. They force a radical reassessment of the timing, ecology and environmental setting of the fish-tetrapod transition, as well as the completeness of the body fossil record.</p>
  •  
28.
  • Rubin, Carl-Johan, et al. (författare)
  • Whole genome resequencing reveals loci under selection during chicken domestication
  • 2010
  • Ingår i: Nature. - 0028-0836 .- 1476-4687. ; 464:7288, s. 587-591
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Domestic animals are excellent models for genetic studies of phenotypic evolution. They have evolved genetic adaptations to a new environment, the farm, and have been subjected to strong human-driven selection leading to remarkable phenotypic changes in morphology, physiology and behaviour. Identifying the genetic changes underlying these developments provides new insight into general mechanisms by which genetic variation shapes phenotypic diversity. Here we describe the use of massively parallel sequencing to identify selective sweeps of favourable alleles and candidate mutations that have had a prominent role in the domestication of chickens (Gallus gallus domesticus) and their subsequent specialization into broiler (meat-producing) and layer (egg-producing) chickens. We have generated 44.5-fold coverage of the chicken genome using pools of genomic DNA representing eight different populations of domestic chickens as well as red jungle fowl (Gallus gallus), the major wild ancestor. We report more than 7,000,000 single nucleotide polymorphisms, almost 1,300 deletions and a number of putative selective sweeps. One of the most striking selective sweeps found in all domestic chickens occurred at the locus for thyroid stimulating hormone receptor (TSHR), which has a pivotal role in metabolic regulation and photoperiod control of reproduction in vertebrates. Several of the selective sweeps detected in broilers overlapped genes associated with growth, appetite and metabolic regulation. We found little evidence that selection for loss-of-function mutations had a prominent role in chicken domestication, but we detected two deletions in coding sequences that we suggest are functionally important. This study has direct application to animal breeding and enhances the importance of the domestic chicken as a model organism for biomedical research.</p>
  •  
29.
  • Rubin, Carl-Johan, et al. (författare)
  • Whole-genome resequencing reveals loci under selection during chicken domestication
  • 2010
  • Ingår i: Nature. - London : Macmillan Publishers Limited. - 0028-0836 .- 1476-4687. ; 464, s. 587-591
  • Tidskriftsartikel (refereegranskat)abstract
    • <p>Domestic animals are excellent models for genetic studies of phenotypic evolution(1-3). They have evolved genetic adaptations to a new environment, the farm, and have been subjected to strong human-driven selection leading to remarkable phenotypic changes in morphology, physiology and behaviour. Identifying the genetic changes underlying these developments provides new insight into general mechanisms by which genetic variation shapes phenotypic diversity. Here we describe the use of massively parallel sequencing to identify selective sweeps of favourable alleles and candidate mutations that have had a prominent role in the domestication of chickens (Gallus gallus domesticus) and their subsequent specialization into broiler (meat-producing) and layer (egg-producing) chickens. We have generated 44.5-fold coverage of the chicken genome using pools of genomic DNA representing eight different populations of domestic chickens as well as red jungle fowl (Gallus gallus), the major wild ancestor(4). We report more than 7,000,000 single nucleotide polymorphisms, almost 1,300 deletions and a number of putative selective sweeps. One of the most striking selective sweeps found in all domestic chickens occurred at the locus for thyroid stimulating hormone receptor (TSHR), which has a pivotal role in metabolic regulation and photoperiod control of reproduction in vertebrates. Several of the selective sweeps detected in broilers overlapped genes associated with growth, appetite and metabolic regulation. We found little evidence that selection for loss-of-function mutations had a prominent role in chicken domestication, but we detected two deletions in coding sequences that we suggest are functionally important. This study has direct application to animal breeding and enhances the importance of the domestic chicken as a model organism for biomedical research.</p>
  •  
30.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 21-30 av 62
  • Föregående 12[3]4567Nästa
Åtkomst
fritt online (3)
Typ av publikation
tidskriftsartikel (61)
annan publikation (1)
Typ av innehåll
refereegranskat (59)
övrigt vetenskapligt (8)
Författare/redaktör
Melander, Olle, (5)
Strachan, David P. (5)
McCarthy, Mark I (5)
Paré, Guillaume (5)
Samani, Nilesh J. (5)
Barroso, Inês (5)
visa fler...
Johnson, Toby (5)
Thompson, John R. (5)
Soranzo, Nicole (4)
Boomsma, Dorret I. (4)
Gudnason, Vilmundur (4)
Hofman, Albert (4)
Hottenga, Jouke-Jan (4)
Montgomery, Grant W. (4)
Rotter, Jerome I. (4)
Uitterlinden, Andre ... (4)
Martin, Nicholas G. (4)
Launer, Lenore J. (4)
Wareham, Nicholas J (4)
Ridker, Paul M., (4)
Chasman, Daniel I., (4)
Boehnke, Michael (4)
Mohlke, Karen L (4)
Ingelsson, Erik (4)
Salomaa, Veikko (4)
Havulinna, Aki S. (4)
Surakka, Ida (4)
Ripatti, Samuli (4)
Mangino, Massimo (4)
Willemsen, Gonneke (4)
Gieger, Christian (4)
Kaprio, Jaakko (4)
Peltonen, Leena (4)
Lettre, Guillaume (4)
Willer, Cristen J. (4)
Heid, Iris M. (4)
Luan, Jian'an (4)
Thorleifsson, Gudmar (4)
Aulchenko, Yurii S. (4)
Feitosa, Mary F. (4)
Hayward, Caroline (4)
Voight, Benjamin F. (4)
Zhao, Jing Hua (4)
Perola, Markus (4)
Kaplan, Lee M. (4)
Koenig, Inke R. (4)
Sanna, Serena (4)
Vitart, Veronique (4)
Ziegler, Andreas (4)
Campbell, Harry (4)
visa färre...
Lärosäte
Uppsala universitet (20)
Karolinska Institutet (14)
Lunds universitet (10)
Stockholms universitet (7)
Göteborgs universitet (5)
Sveriges Lantbruksuniversitet (4)
visa fler...
Linköpings universitet (3)
Umeå universitet (2)
Kungliga Tekniska Högskolan (2)
Mittuniversitetet (1)
visa färre...
Språk
Engelska (62)
Forskningsämne (UKÄ/SCB)
Naturvetenskap (31)
Medicin och hälsovetenskap (19)
Teknik (1)
Lantbruksvetenskap (1)
År
 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy