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Träfflista för sökning "L773:0028 0836 OR L773:1476 4687 srt2:(1990-1999);pers:(Torchia J.)"

Sökning: L773:0028 0836 OR L773:1476 4687 > (1990-1999) > Torchia J.

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1.
  • Heinzel, T., et al. (författare)
  • A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression
  • 1997
  • Ingår i: Nature. - : Nature Publishing Group. - 0028-0836 .- 1476-4687. ; 387:6628, s. 43-48
  • Tidskriftsartikel (refereegranskat)abstract
    • Transcriptional repression by nuclear receptors has been correlated to binding of the putative co-repressor, N-CoR. A complex has been identified that contains N-CoR, the Mad presumptive co-repressor mSin3, and the histone deacetylase mRPD3, and which is required for both nuclear receptor- and Mad-dependent repression, but not for repression by transcription factors of the ets-domain family. These data predict that the ligand-induced switch of heterodimeric nuclear receptors from repressor to activator functions involves the exchange of complexes containing histone deacetylases with those that have histone acetylase activity.
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2.
  • Hörlein, A. J., et al. (författare)
  • Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor
  • 1995
  • Ingår i: Nature. - : Nature Publishing Group. - 0028-0836 .- 1476-4687. ; 377:6548, s. 397-404
  • Tidskriftsartikel (refereegranskat)abstract
    • Thyroid-hormone and retinoic-acid receptors exert their regulatory functions by acting as both activators and repressors of gene expression. A nuclear receptor co-repressor (N-CoR) of relative molecular mass 270K has been identified which mediates ligand-independent inhibition of gene transcription by these receptors, suggesting that the molecular mechanisms of repression by thyroid-hormone and retinoic-acid receptors are analogous to the co-repressor-dependent transcriptional inhibitory mechanisms of yeast and Drosophila.
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