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The Expression of HSD17B12 Is Associated with COX-2 Expression and Is Increased in High-Grade Epithelial Ovarian Cancer

Kemilainen, H. (author)
Huhtinen, K. (author)
Auranen, A. (author)
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Carpen, O. (author)
Strauss, L. (author)
Poutanen, Matti (author)
Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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 (creator_code:org_t)
2018-01-12
2018
English.
In: Oncology. - : S. Karger AG. - 0030-2414 .- 1423-0232. ; 94:4, s. 233-242
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Objective: The aim of this study was to characterize the expression of hydroxysteroid (17 beta) dehydrogenase type 12 (HSD17B12), an enzyme involved in the synthesis of arachidonic acid (AA), in ovarian cancer, and to study its coexpression with its upstream and downstream enzymes in the AA pathway, namely elongation of very long chain fatty acids protein 5 (ELOVL5) and cyclooxygenase-2 (COX-2), respectively. Materials and Methods: Samples from benign and malignant ovarian neoplastic lesions were immunohistochemically stained with HSD17B12, ELOVL5, and COX-2. The staining intensities were quantified with the QuantCenter program, and the results were confirmed with visual inspection. Statistical significances were calculated with the Student t test, the Mann-Whitney test, linear regression, or ANOVA. Results: The expression of the HSD17B12, ELOVL5, and COX-2 enzymes increased according to the grade of the endometrioid ovarian adenocarcinomas. In contrast, in serous adenocarcinomas, staining with ELOVL5 was constantly weak, whereas the expression of HSD17B12 and COX-2 increased with the grade or FIGO stage of the cancer, respectively. Conclusions: The expression of HSD17B12 increased along with the severity of ovarian cancer, and the expression mimicked COX-2 expression and intensity. This further suggests the involvement of HSD17B12 in AA production, and its coexpression with COX-2 indicates a role for the enzyme in the increased prostaglandin production during ovarian cancer progression. (C) 2018 S. Karger AG, Basel

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Keyword

HSD17B12
COX-2
ELOVL5
Arachidonic acid
Ovarian cancer
breast-cancer
cell-proliferation
cyclooxygenase-2
17-beta-hydroxysteroid-dehydrogenase
carcinoma
aromatase
angiogenesis
elongation
metabolism
pathways

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ref (subject category)
art (subject category)

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By the author/editor
Kemilainen, H.
Huhtinen, K.
Auranen, A.
Carpen, O.
Strauss, L.
Poutanen, Matti
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Cancer and Oncol ...
Articles in the publication
Oncology
By the university
University of Gothenburg

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