| 1. |
- Andersson, M., et al.
(författare)
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Using optical tweezers for measuring the interaction forces between human bone cells and implant surfaces: System design and force calibration
- 2007
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Ingår i: Rev Sci Instrum. - : AIP Publishing. ; 78:7
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Tidskriftsartikel (refereegranskat)abstract
- Optical tweezers were used to study the interaction and attachment of human bone cells to various types of medical implant materials. Ideally, the implant should facilitate cell attachment and promote migration of the progenitor cells in order to decrease the healing time. It is therefore of interest, in a controlled manner, to be able to monitor the cell adhesion process. Results from such studies would help foresee the clinical outcome of integrating medical implants. The interactions between two primary cell culture models, human gingival fibroblasts and bone forming human osteoblast cells, and three different implant materials, glass, titanium, and hydroxyapatite, were studied. A novel type of optical tweezers, which has a newly designed quadrant detector and a powerful 3 W laser was constructed and force calibrated using two different methods: one method in which the stiffness of the optical trap was obtained by monitoring the phase lag between the trap and the moved object when imposing a forced oscillation on the trapped object and another method in which the maximum trapping force was derived from the critical velocity at which the object escapes the trap. Polystyrene beads as well as cells were utilized for the calibrations. This is the first time that cells have been used directly for these types of force calibrations and, hence, direct measurements of forces exerted on cells can be performed, thus avoiding the difficulties often encountered when translating the results obtained from cell measurements to the calibrations obtained with reference materials. This more straightforward approach represents an advantage in comparison to established methods.
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| 2. |
- Andersson, Patrik U, 1970, et al.
(författare)
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Efficient source for the production of ultradense deuterium D(-1) for laser-induced fusion (ICF)
- 2011
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Ingår i: Review of Scientific Instruments. - : AIP Publishing. - 0034-6748 .- 1089-7623. ; 82
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Tidskriftsartikel (refereegranskat)abstract
- A novel source which simplifies the study of ultradense deuterium D(-1) is now described. This means one step further toward deuterium fusion energy production. The source uses internal gas feed and D(-1) can now be studied without time-of-flight spectral overlap from the related dense phase D(1). The main aim here is to understand the material production parameters, and thus a relatively weak laser with focused intensity ≤1012 W cm−2 is employed for analyzing the D(-1) material. The properties of the D(-1) material at the source are studied as a function of laser focus position outside the emitter, deuterium gas feed, laser pulse repetition frequency and laser power, and temperature of the source. These parameters influence the D(-1) cluster size, the ionization mode, and the laser fragmentation patterns.
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| 3. |
- Banuazizi, S. Amir Hossein, et al.
(författare)
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Microwave probe stations with throw-dimensional control of the magnetic field to study high-frequency dynamic in nanoscale devices
- 2018
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Ingår i: Review of Scientific Instruments. - : AIP Publishing. - 0034-6748 .- 1089-7623. ; 89:6
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Tidskriftsartikel (refereegranskat)abstract
- We present two microwave probe stations with motorized rotary stages for adjusting the magnitude and angle of the applied magnetic field. In the first system, the magnetic field is provided by an electromagnet and can be adjusted from 0 to similar to 1.4 T while its polar angle (theta) can be varied from 0 degrees to 360 degrees. In the second system the magnetic field is provided by a Halbach array permanent magnet, which can be rotated and translated to cover the full range of polar (theta) and azimuthal (phi) angles with a tunable field magnitude up to similar to 1 T. Both systems are equipped with microwave probes, bias-Ts, amplifiers, and spectrum analyzers, to allow for microwave characterization up to 40 GHz, as well as software to automatically perform continuous large sets of electrical and microwave measurements. Published by AIP Publishing.
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| 4. |
- Bengtsson, Lars, 1963
(författare)
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A microcontroller-based lock-in amplifier for sub-milliohm resistance measurements
- 2012
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Ingår i: Review of Scientific Instruments. - : AIP Publishing. - 0034-6748 .- 1089-7623. ; 83:7
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents a novel approach to the design of a digital ohmmeter with a resolution of <60 μΩ based on a general-purpose microcontroller and a high-impedance instrumentation amplifier only. The design uses two digital I/O-pins to alternate the current through the sample resistor and combined with a proper firmware routine, the design is a lock-in detector that discriminates any signal that is out of phase/frequency with the reference signal. This makes it possible to selectively detect the μV drop across sample resistors down to 55.6 μΩ using only the current that can be supplied by the digital output pins of a microcontroller. This is achieved without the need for an external reference signal generator and does not rely on the computing processing power of a digital signal processor.
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| 5. |
- Bengtsson, Lars, 1963
(författare)
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Implementation of high-resolution time-to-digital converter in 8-bit microcontrollers
- 2012
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Ingår i: Review of Scientific Instruments. - : AIP Publishing. - 0034-6748 .- 1089-7623. ; 83:article no. 045107
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Tidskriftsartikel (refereegranskat)abstract
- This paper will demonstrate how a time-to-digital converter (TDC) with sub-nanosecond resolution can be implemented into an 8-bit microcontroller using so called “direct” methods. This means that a TDC is created using only five bidirectional digital input–output-pins of a microcontroller and a few passive components (two resistors, a capacitor, and a diode). We will demonstrate how a TDC for the range 1–10 μs is implemented with 0.17 ns resolution. This work will also show how to linearize the output by combining look-up tables and interpolation.
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| 6. |
- Berntsen, Peter, 1974, et al.
(författare)
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The serial millisecond crystallography instrument at the Australian Synchrotron incorporating the "Lipidico" injector
- 2019
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Ingår i: Review of Scientific Instruments. - : AIP Publishing. - 0034-6748 .- 1089-7623. ; 90:8
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Tidskriftsartikel (refereegranskat)abstract
- A serial millisecond crystallography (SMX) facility has recently been implemented at the macromolecular crystallography beamline, MX2 at the Australian Synchrotron. The setup utilizes a combination of an EIGER X 16M detector system and an in-house developed high-viscosity injector, "Lipidico." Lipidico uses a syringe needle to extrude the microcrystal-containing viscous media and it is compatible with commercially available syringes. The combination of sample delivery via protein crystals suspended in a viscous mixture and a millisecond frame rate detector enables high-throughput serial crystallography at the Australian Synchrotron. A hit-finding algorithm, based on the principles of "robust-statistics," is employed to rapidly process the data. Here we present the first SMX experimental results with a detector frame rate of 100 Hz (10 ms exposures) and the Lipidico injector using a mixture of lysozyme microcrystals embedded in high vacuum silicon grease. Details of the experimental setup, sample injector, and data analysis pipeline are designed and developed as part of the Australian Synchrotron SMX instrument and are reviewed here. Published under license by AIP Publishing.
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| 7. |
- Blahins, J., et al.
(författare)
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Operating a cesium sputter source in a pulsed mode
- 2020
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Ingår i: Review of Scientific Instruments. - : AIP Publishing. - 0034-6748 .- 1089-7623. ; 91:2
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Tidskriftsartikel (refereegranskat)abstract
- A scheme is presented for pulsing of a cesium sputter negative ion source by periodically switching on and off the high voltage driving the sputtering process. We demonstrate how the pulsed ion beam can be used in combination with a pulsed laser (6 ns pulse length) that has a 10 Hz repetition rate to study the photodetachment process, where a negative ion is neutralized due to the absorption of a photon. In such experiments, where the ion beam is used only for a small fraction of the time, we show that the pulsed mode operation can increase the lifetime of a cathode by two orders of magnitude as compared with DC operation. We also investigate how the peak ion current compares with the ion current obtained when the source is run in a DC mode. We find that the peak current in the pulsed mode is strongly dependent on the ion species. In some cases, we observed a strong enhancement, whereas others showed only a moderate enhancement, or even a decrease, in the peak current. We conclude that the pulsed mode operation can be of great value when the negative ion to be investigated requires cathodes that have short lifetimes, expensive materials, or those with relatively small ion beam yields, in the latter case limited to elements with large enhancement factors. Published under license by AIP Publishing.
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| 8. |
- Diehl, C., et al.
(författare)
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Ion optical design of a collinear laser-negative ion beam apparatus
- 2011
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Ingår i: Review of Scientific Instruments. - : AIP Publishing. - 0034-6748 .- 1089-7623. ; 82:5
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Tidskriftsartikel (refereegranskat)abstract
- An apparatus for photodetachment studies on atomic and molecular negative ions of medium up to heavy mass (M ≃ 500) has been designed and constructed. Laser and ion beams are merged in the apparatus in a collinear geometry and atoms, neutral molecules and negative ions are detected in the forward direction. The ion optical design and the components used to optimize the mass resolution and the transmission through the extended field-free interaction region are described. A 90° sector field magnet with 50 cm bending radius in combination with two slits is used for mass dispersion providing a resolution of M/ΔM≅800 for molecular ions and M/ΔM≅400 for atomic ions. The difference in mass resolution for atomic and molecular ions is attributed to different energy distributions of the sputtered ions. With 1 mm slits, transmission from the source through the interaction region to the final ion detector was determined to be about 0.14%.
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| 9. |
- Hartman, Henrik, et al.
(författare)
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First storage of ion beams in the Double Electrostatic Ion-Ring Experiment : DESIREE
- 2013
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Ingår i: Review of Scientific Instruments. - : American Institute of Physics (AIP). - 0034-6748 .- 1089-7623. ; 84:5
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Tidskriftsartikel (refereegranskat)abstract
- We report on the first storage of ion beams in the Double ElectroStatic Ion Ring ExpEriment, DESIREE, at Stockholm University. We have produced beams of atomic carbon anions and small carbon anion molecules (Cn-, n = 1, 2, 3, 4) in a sputter ion source. The ion beams were accelerated to 10 keV kinetic energy and stored in an electrostatic ion storage ring enclosed in a vacuum chamber at 13 K. For 10 keV C2- molecular anions we measure the residual-gas limited beam storage lifetime to be 448 s +/- 18 s with two independent detector systems. Using the measured storage lifetimes we estimate that the residual gas pressure is in the 10-14 mbar range. When high current ion beams are injected, the number of stored particles does not follow a single exponential decay law as would be expected for stored particles lost solely due to electron detachment in collision with the residual-gas. Instead, we observe a faster initial decay rate, which we ascribe to the effect of the space charge of the ion beam on the storage capacity.
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| 10. |
- Hartmann, G., et al.
(författare)
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Circular dichroism measurements at an x-ray free-electron laser with polarization control
- 2016
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Ingår i: Review of Scientific Instruments. - : AIP Publishing. - 0034-6748 .- 1089-7623. ; 87:8
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Tidskriftsartikel (refereegranskat)abstract
- A non-destructive diagnostic method for the characterization of circularly polarized, ultraintense, short wavelength free-electron laser (FEL) light is presented. The recently installed Delta undulator at the LCLS (Linac Coherent Light Source) at SLAC National Accelerator Laboratory (USA) was used as showcase for this diagnostic scheme. By applying a combined two-color, multi-photon experiment with polarization control, the degree of circular polarization of the Delta undulator has been determined. Towards this goal, an oriented electronic state in the continuum was created by non-resonant ionization of the O2 1s core shell with circularly polarized FEL pulses at hν 700 eV. An also circularly polarized, highly intense UV laser pulse with hν 3.1 eV was temporally and spatially overlapped, causing the photoelectrons to redistribute into so-called sidebands that are energetically separated by the photon energy of the UV laser. By determining the circular dichroism of these redistributed electrons using angle resolving electron spectroscopy and modeling the results with the strong-field approximation, this scheme allows to unambiguously determine the absolute degree of circular polarization of any pulsed, ultraintense XUV or X-ray laser source. © 2016 Author(s).
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