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Träfflista för sökning "L773:0036 8075 OR L773:1095 9203 ;lar1:(kau)"

Search: L773:0036 8075 OR L773:1095 9203 > Karlstad University

  • Result 1-3 of 3
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1.
  • Caporale, N., et al. (author)
  • From cohorts to molecules: Adverse impacts of endocrine disrupting mixtures
  • 2022
  • In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 375:6582
  • Journal article (peer-reviewed)abstract
    • Convergent evidence associates exposure to endocrine disrupting chemicals (EDCs) with major human diseases, even at regulation-compliant concentrations. This might be because humans are exposed to EDC mixtures, whereas chemical regulation is based on a risk assessment of individual compounds. Here, we developed a mixture-centered risk assessment strategy that integrates epidemiological and experimental evidence. We identified that exposure to an EDC mixture in early pregnancy is associated with language delay in offspring. At human-relevant concentrations, this mixture disrupted hormone-regulated and disease-relevant regulatory networks in human brain organoids and in the model organisms Xenopus leavis and Danio rerio, as well as behavioral responses. Reinterrogating epidemiological data, we found that up to 54% of the children had prenatal exposures above experimentally derived levels of concern, reaching, for the upper decile compared with the lowest decile of exposure, a 3.3 times higher risk of language delay. © 2022 American Association for the Advancement of Science. All rights reserved.
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2.
  • Duncan, R. G., et al. (author)
  • The sociopolitical in human genetics education
  • 2024
  • In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 383:6685, s. 826-828
  • Journal article (peer-reviewed)
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3.
  • Schmidt-Mende, Lukas, et al. (author)
  • Self-organised Discotic Liquid Crystals for High Efficiency Organic Photovoltaics
  • 2001
  • In: Science. - Washington, DC, USA : American Association for the Advancement of Science. - 0036-8075 .- 1095-9203. ; 293:10 august, s. 1119-1122
  • Journal article (peer-reviewed)abstract
    • Self-organization of liquid crystalline and crystalline-conjugated materials has been used to create, directly from solution, thin films with structures optimized for use in photodiodes. The discotic liquid crystal hexa-perihexabenzocoronene was used in combination with a perylene dye to produce thin films with vertically segregated perylene and hexabenzocoronene, with large interfacial surface area. When incorporated into diode structures, these films show photovoltaic response with external quantum efficiencies of more than 34 percent near 490 nanometers. These efficiencies result from efficient photoinduced charge transfer between the hexabenzocoronene and perylene, as well as from effective transport of charges through vertically segregated perylene and hexabenzocoronene psystems. This development demonstrates that complex structures can be engineered from novel materials by means of simple solution-processing steps and may enable inexpensive, high-performance, thin-film photovoltaic technology
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