Tyck till om SwePub Sök
här!
Search: L773:0046 8177 OR L773:1532 8392
> (2015-2019)
> Nodin Björn >
Immunohistochemical...
Immunohistochemical profiles in primary lung cancers and epithelial pulmonary metastases
-
- Vidarsdottir, Halla (author)
- Lund University,Lunds universitet,Förbättrad diagnostik och prognostik vid lungcancer och metastaser till lunga,Forskargrupper vid Lunds universitet,Improved diagnostics and prognostics of lung cancer and metastases to the lungs,Lund University Research Groups,Helsingborg Hospital
-
- Tran, Lena (author)
- Department of Genetics and Pathology, Division of Laboratory Medicine, Region Skåne, SE-221 85 Lund, Sweden
-
- Nodin, Björn (author)
- Lund University,Lunds universitet,Personlig patologi och cancerbehandling,Forskargrupper vid Lunds universitet,Personalized Pathology & Cancer Therapy,Lund University Research Groups
-
show more...
-
- Jirström, Karin (author)
- Lund University,Lunds universitet,Personlig patologi och cancerbehandling,Forskargrupper vid Lunds universitet,Personalized Pathology & Cancer Therapy,Lund University Research Groups,Region Skåne
-
- Planck, Maria (author)
- Lund University,Lunds universitet,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,Research Group Lung Cancer,Lund University Research Groups,Skåne University Hospital
-
- Jönsson, Per (author)
- Lund University,Lunds universitet,Thoraxkirurgi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Thoracic Surgery,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
-
- Mattsson, Johanna Sofia Margareta, 1985- (author)
- Uppsala University,Uppsala universitet,Klinisk och experimentell patologi,Patrick Micke
-
- Botling, Johan (author)
- Uppsala University,Uppsala universitet,Klinisk och experimentell patologi,Johan Botling
-
- Micke, Patrick (author)
- Uppsala University,Uppsala universitet,Klinisk och experimentell patologi,Patrick Micke
-
- Brunnström, Hans (author)
- Lund University,Lunds universitet,Förbättrad diagnostik och prognostik vid lungcancer och metastaser till lunga,Forskargrupper vid Lunds universitet,Improved diagnostics and prognostics of lung cancer and metastases to the lungs,Lund University Research Groups,Region Skåne
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- English.
-
In: Human Pathology. - : Elsevier BV. - 0046-8177 .- 1532-8392. ; 84, s. 221-230
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://lup.lub.lu.s...
-
show less...
Abstract
Subject headings
Close
- Correct diagnosis of pulmonary tumors is essential for treatment decision and often rely on immunohistochemical markers. We stained tissue microarrays from resected primary lung cancer (n=665) and pulmonary metastases (n=425) for CK7, CK20, CDX2, CK5, p40, p63, TTF-1, napsin A, GATA3 and PAX8 to systematically assess the diagnostic value of these markers. Primary lung adenocarcinomas expressed TTF-1 in 90% and napsin A in 84% of the cases, while 10% were positive for p63, 7% for CDX2, 2% for CK20 and 2% for GATA3. Only 68% of the lung adenocarcinomas were positive for CK7, TTF-1 and napsin A and negative for all other markers. Primary lung squamous cell carcinomas expressed CK5, p40 and p63 in 94-97% of cases, while 44% were positive for CK7, 20% for GATA3, 7% for CDX2 and 3% for TTF-1. Rare cases expressed PAX8, CK20 or napsin A. Pulmonary metastases of colorectal cancer were positive for CK20 in 83% and CDX2 in 99% of the cases. Rare cases expressed CK7, p63 or PAX8, while 4% expressed TTF-1. Pulmonary metastases of renal cell carcinomas were positive for PAX8 in 74%, napsin A in 7% and CK7 in 7% of the cases. Pulmonary metastases of breast cancer were positive for GATA3 in 93% and CK7 in 78% of the cases, while 15% expressed CK5. Information on expression and patterns of immunohistochemical markers facilitates histopathological diagnostics. Evidently, unusual immune profiles occur and may lead to incorrect diagnosis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- CDX2
- Cytokeratin
- GATA3
- Napsin a
- TTF-1
- Tissue Microarray
- Patologi
- Pathology
- CDX2
- Cytokeratin
- GATA3
- Napsin A
- Tissue microarray
- TTF-1
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Vidarsdottir, Ha ...
-
Tran, Lena
-
Nodin, Björn
-
Jirström, Karin
-
Planck, Maria
-
Jönsson, Per
-
show more...
-
Mattsson, Johann ...
-
Botling, Johan
-
Micke, Patrick
-
Brunnström, Hans
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Clinical Laborat ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
Human Pathology
- By the university
-
Uppsala University
-
Lund University