| 1. |
- Dengler, Reinhard, et al.
(författare)
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AANEM - IFCN Glossary of Terms in Neuromuscular Electrodiagnostic Medicine and Ultrasound
- 2020
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Ingår i: Muscle and Nerve. - : WILEY. - 0148-639X .- 1097-4598. ; 62:1, s. 10-12
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Forskningsöversikt (övrigt vetenskapligt/konstnärligt)abstract
- Modern neuromuscular electrodiagnosis (EDX) and neuromuscular ultrasound (NMUS) require a universal language for effective communication in clinical practice and research and, in particular, for teaching young colleagues. Therefore, the AANEM and the IFCN have decided to publish a joint glossary as they feel the need for an updated terminology to support educational activities in neuromuscular EDX and NMUS in all parts of the world. In addition NMUS has been rapidly progressing over the last years and is now widely used in the diagnosis of disorders of nerve and muscle in conjunction with EDX. This glossary has been developed by experts in the field of neuromuscular EDX and NMUS on behalf of the AANEM and the IFCN and has been agreed upon by electronic communication between January and November 2019. It is based on the glossaries of the AANEM from 2015 and of the IFCN from 1999. The EDX and NMUS terms and the explanatory illustrations have been updated and supplemented where necessary. The result is a comprehensive glossary of terms covering all fields of neuromuscular EDX and NMUS. It serves as a standard reference for clinical practice, education and research worldwide.
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| 2. |
- Rostedt Punga, Anna, et al.
(författare)
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Acetylcholinesterase inhibitors in myasthenia gravis : to be or not to be?
- 2009
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Ingår i: Muscle and Nerve. - : Wiley. - 0148-639X .- 1097-4598. ; 39:6, s. 724-728
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Forskningsöversikt (refereegranskat)abstract
- Myasthenia gravis (MG) is an autoimmune disorder usually caused by antibodies against either the acetylcholine receptor (AChR) or muscle-specific tyrosine kinase (MuSK) at the neuromuscular junction. Neuromuscular transmission failure results in muscle fatigue and weakness that can be treated symptomatically with acetylcholinesterase inhibitors (AChEIs). Long-term treatment with nonselective AChEIs may have considerable drawbacks; thus, this medication is ideally tapered when strength improves. Patients with AChR antibodies respond beneficially to treatment, whereas patients with MuSK antibodies generally do not. Recently, the selective AChEI EN101, which specifically targets the isoform of "read-through" AChE (AChE-R), has been developed and may be of importance for symptomatic relief in AChR-antibody seropositive MG. This article is a review of the mechanisms, therapeutic effects, and drawbacks, with both old and new AChEIs in MG.
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| 3. |
- Stålberg, Erik V., et al.
(författare)
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Jitter recordings with concentric needle electrodes
- 2009
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Ingår i: Muscle and Nerve. - : Wiley. - 0148-639X .- 1097-4598. ; 40:3, s. 331-339
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Forskningsöversikt (refereegranskat)abstract
- Neuromuscular jitter is generally recorded with a single fiber (SF) electromyography (EMG) electrode. Due to concern about using reusable needle electrodes, an acceptable alternative for the SF electrode has been sought. This is a review of the issues involved in using disposable concentric needle (CN) electrodes to measure jitter. Signals recorded with CN electrodes frequently represent the summation of many single fiber action potentials, which will decrease the apparent jitter. The influence of these artifacts on the final result also depends on the analysis method. Reference values obtained with CN electrodes correlate with SF EMG values, but they are a few microseconds lower. Overall results show that the CN method is a good alternative to SFEMG and will facilitate the use of jitter analysis. The results must be interpreted with caution, particularly in borderline cases, but they may be acceptable for clinical use when SF electrodes cannot be used.
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| 4. |
- Wallin, Gunnar B, 1936, et al.
(författare)
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Sympathetic neural control of integrated cardiovascular function: insights from measurement of human sympathetic nerve activity.
- 2007
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Ingår i: Muscle & nerve. - : Wiley. - 0148-639X .- 1097-4598. ; 36:5, s. 595-614
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Forskningsöversikt (refereegranskat)abstract
- Sympathetic neural control of cardiovascular function is essential for normal regulation of blood pressure and tissue perfusion. In the present review we discuss sympathetic neural mechanisms in human cardiovascular physiology and pathophysiology, with a focus on evidence from direct recordings of sympathetic nerve activity using microneurography. Measurements of sympathetic nerve activity to skeletal muscle have provided extensive information regarding reflex control of blood pressure and blood flow in conditions ranging from rest to postural changes, exercise, and mental stress in populations ranging from healthy controls to patients with hypertension and heart failure. Measurements of skin sympathetic nerve activity have also provided important insights into neural control, but are often more difficult to interpret since the activity contains several types of nerve impulses with different functions. Although most studies have focused on group mean differences, we provide evidence that individual variability in sympathetic nerve activity is important to the ultimate understanding of these integrated physiological mechanisms.
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