SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "L773:0250 7005 OR L773:1791 7530 ;srt2:(2000-2004)"

Sökning: L773:0250 7005 OR L773:1791 7530 > (2000-2004)

Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
31.
  •  
32.
  •  
33.
  •  
34.
  • Blind, Per-Jonas, et al. (författare)
  • Unique antitumour effects of L-2,4 diaminobutyric acid on cultured hepatoma cells
  • 2003
  • Ingår i: Anticancer research. - International Institute of Cancer Research. - 1791-7530. ; 23:2B, s. 1245-1248
  • Tidskriftsartikel (refereegranskat)abstract
    • A single hepatoma cell line was grown in vitro and incubated with L-2,4 diaminobutyric acid (DAB), a non-metabolizable amino acid, under various conditions. The tumour cells were irreversibly damaged by incubation for 8 hours with 8 mmol/L of DAB. The tumour cell-destroying effect of DAB was dose- and time-dependent with no effect at a DAB concentration of 1.6 mmol/L. The presence of N-methyl a-aminoisobutyric acid (a specific substrate of amino acid transport system A) in the incubation medium abrogated the tumour cell destructive effect of DAB in a dose- dependent fashion. The presence of it on-physiological amino acids in the incubation medium per se was not the cause of tumour cell destruction, since inclusion of a-amino-isobutyric acid and N-methyl a-aminoisobutyric acid in the incubation medium did not influence the viability of hepatoma cells. We conclude that the tumour cell destructive effect of DAB was the result of a huge and unlimited uptake of DAB energized by the Na+-gradient and that this uptake was not subjected to the law of saturation kinetics. This was combined with a tumour cell energy crisis in attempts to restore the Na+-gradient.
  •  
35.
  •  
36.
  •  
37.
  • Burger, AM, et al. (författare)
  • The breast cancer-associated gene Di12 has oncogenic activity
  • 2003
  • Ingår i: Anticancer research. - International Institute of Cancer Research. - 1791-7530. ; 23:3A, s. 2027-2033
  • Tidskriftsartikel (refereegranskat)abstract
    • The breast cancer-associated gene Di12 encodes a novel protein, which was found overexpressed in invasive ductal carcinomas of the breast. In experiments designed to assess the role of the Di12 gene in oncogenesis, the overexpression of 339 N-terminal amino acids of this gene in NIH3T3 cells resulted in cellular transformation and in vivo tumorigenesis. NIH3T3-Di12 tumor cell growth was partly reversible upon Di12 antisense treatment. In addition, transfortnation of the ER + human breast cancer cell line MCF- 7 resulted in hormone independent growth of these tumors in nude mice. Di12 expression in NIH3T3 and MCF-7 tumor cells was confirmed by RT-PCR and mabDi12 immunostaining. Immunohistochemistry using mabDi12 on an arrayed collection of 106 invasive breast tumors further underlined the expression of the gene in over 75% of advanced stage breast cancers. Our data indicate that Di12 expression is oncogenic in in vitro transformation and in vivo tumorigenic assays.
  •  
38.
  •  
39.
  •  
40.
  •  
Skapa referenser, mejla, bekava och länka
Typ av publikation
tidskriftsartikel (140)
konferensbidrag (12)
Typ av innehåll
refereegranskat (139)
övrigt vetenskapligt (17)
Författare/redaktör
Rubio, CA, (18)
Brodin, O, (8)
Bergqvist, M. (7)
Hultborn, Ragnar, 19 ... (6)
Wagenius, G. (6)
Munck-Wikland, E, (6)
visa fler...
Brattstrom, D (6)
Dimberg, Jan, (6)
Hjerpe, A, (5)
Nilsson, S (5)
Nilsson, A (5)
Strang, P, (5)
Tribukait, B (5)
Edgren, M, (5)
Biberfeld, P, (4)
Dobra, K, (4)
Strang, Peter, 1957- ... (4)
Lewensohn, R, (4)
Dalianis, T, (4)
Auer, G, (4)
Lennernäs, Bo, 1963- ... (4)
Palm, Stig, 1964-, (4)
Wågsäter, Dick, (4)
Jacobsson, Lars, 194 ... (4)
Lindegren, Sture, 19 ... (4)
Bäck, Tom, 1964-, (4)
Lindholm, J. (4)
Hesselius, P (4)
Klominek, J (4)
Stenram, Unne, (3)
Landberg, Göran, (3)
Naredi, Peter, 1955- ... (3)
Kato, Y. (3)
Glimelius, B, (3)
Hogmo, A. (3)
Hellstrand, Kristoff ... (3)
Jonsson, G (3)
ERNBERG, I, (3)
Li, Li, (3)
Andersson, Håkan, 19 ... (3)
Hugander, A (3)
Liu, ZW (3)
Hu, LF, (3)
Shao, JY (3)
Zeng, YX (3)
Heiden, T (3)
Ulmsten, Ulf, (3)
Fu, Xin, (3)
Amorosi, A. (3)
Delle, Ulla, 1955-, (3)
visa färre...
Lärosäte
Karolinska Institutet (89)
Lunds universitet (19)
Göteborgs universitet (18)
Uppsala universitet (8)
Linköpings universitet (8)
Umeå universitet (7)
visa fler...
Högskolan i Jönköping (3)
Kungliga Tekniska Högskolan (1)
Högskolan i Halmstad (1)
visa färre...
Språk
Engelska (152)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (55)
Naturvetenskap (1)

År

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy