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> (2005-2009)
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Radio-iodination of...
Radio-iodination of monoclonal antibody using potassium [125I]-(4-isothiocyanatobenzylammonio)-iodo-decahydro-closo-dodecaborate (iodo-DABI)
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- Orlova, Anna (author)
- Uppsala universitet,Enheten för biomedicinsk strålningsvetenskap,BMS
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- Bruskin, Alexander (author)
- Uppsala universitet,Enheten för biomedicinsk strålningsvetenskap,BMS
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- Sivaev, Igor (author)
- Uppsala universitet,Enheten för biomedicinsk strålningsvetenskap,Organisk kemi
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- Sjöberg, Stefan (author)
- Uppsala universitet,Organisk kemi
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- Lundqvist, Hans (author)
- Uppsala universitet,Enheten för biomedicinsk strålningsvetenskap,BMS
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- Tolmachev, Vladimir (author)
- Uppsala universitet,Enheten för biomedicinsk strålningsvetenskap,BMS
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(creator_code:org_t)
- 2006
- 2006
- English.
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In: Anticancer Research. - 0250-7005 .- 1791-7530. ; 26:2A, s. 1217-23
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Abstract
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- BACKGROUND: Negatively-charged polyhedral boron clusters can be easily halogenated with highly stable boron-halogen bonds and are promising in radionuclide diagnostics and cancer therapy. MATERIALS AND METHODS: The radio-iodination conditions for the closo-dodecaborate anion and for the conjugation of its labeled isothiocyanatobenzylammonio derivative to the monoclonal antibody (mAb) were optimized. RESULTS: The labeling yield was about 90% and the overall conjugation yield was 55-60%. The in vitro stability of the radio-iodinated mAb was good under physiological and non-physiological conditions. The immunoreactivity of the labeled mAb (SK-BR-3 cells) was retained in the one-pot two-step labeling. CONCLUSION: Negatively-charged polyhedral boron clusters can be used for indirect radio-iodination of mAbs.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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